{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:55:14Z","timestamp":1775638514160,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Metastatic lesions to the appendix are rare. They usually present with acute appendicitis or remain asymptomatic and are diagnosed incidentally. Metastases to the appendix have been reported from a number of primary tumor sites including ovary, colon, gastric and lung. We report a laparoscopic appendectomy for a metachronous metastatic lesion to the appendix from the uterine cervix.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 68-year-old woman, who underwent radical hysterectomy for cervical cancer 16\u00a0years previously, presented with nausea and gradually worsening right lower quadrant abdominal pain. Abdominal computed tomography scan showed an enlarged appendix and periappendiceal fat stranding. She was diagnosed with appendicitis and underwent laparoscopic appendectomy. Pathological findings showed adenocarcinoma in the submucosa and muscularis propria. Gastrointestinal endoscopy and positron emission tomography with computed tomography (PET\u2013CT) did not show other lesions. Immunohistochemical analysis showed cytokeratin 7 (CK7) positive, cytokeratin 20 (CK20) negative, estrogen receptor (ER) 70\u201380% and progesterone receptor (PgR) 40\u201350%. The ER and PgR expression was similar to the cervical lesion 16\u00a0years previously, and the diagnosis was a metastatic lesion to the appendix from the uterine cervix.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Metastasis to the appendix from cancer of the uterine cervix is a rare lesion.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-021-01196-6","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T08:03:21Z","timestamp":1620374601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Laparoscopic appendectomy for metastatic cervical cancer presenting as appendicitis"],"prefix":"10.1186","volume":"7","author":[{"given":"Shota","family":"Fukai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Kawarai","family":"Lefor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"1196_CR1","first-page":"e920010","volume":"21","author":"A Daeya","year":"2020","unstructured":"Daeya A, Abdullah A, Hadeel A, Mohammad A. Missed gastric cancer metastasis to the appendix. Am J Case Rep. 2020;21:e920010.","journal-title":"Am J Case Rep."},{"key":"1196_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.5009\/gnl.2010.4.3.351","volume":"4","author":"WJ Yoon","year":"2010","unstructured":"Yoon WJ, Yoon YB, Kim YJ, Ryu JK, Kim YT. Secondary appendiceal tumors: a review of 139 cases. Gut Liver. 2010;4:351\u20136.","journal-title":"Gut Liver"},{"key":"1196_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijscr.2020.10.116","volume":"77","author":"S Toshio","year":"2020","unstructured":"Toshio S, Masato A, Yorihisa S, Tomohiro F, Shintaro H, Masato N, Takamune M, Kiyoaki H, Masayuki B, Goushi M, Kouki W, Yukio I, Shigeyuki M, Akihiro N, Daisuke N, Tetsuro T, Takashi N, Terumitsu S, Takeshi N. Acute perforating appendicitis caused by metastatic squamous cell carcinoma from the lung. Int J Surg Rep. 2020;77:279\u201383.","journal-title":"Int J Surg Rep"},{"issue":"3","key":"1196_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.5009\/gnl.2010.4.3.351","volume":"4","author":"JY Won","year":"2010","unstructured":"Won JY, Yong BY, Youn JK, Ji KR, Yong TK. Secondary appendiceal tumors: a review of 139 cases. Gut Liver. 2010;4(3):351\u20136.","journal-title":"Gut Liver"},{"issue":"1","key":"1196_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40792-018-0467-7","volume":"4","author":"K Yusuke","year":"2018","unstructured":"Yusuke K, Takafumi M, Daiki Y, Yuki A, Tomohide H. Acute appendicitis caused by metastatic adenocarcinoma from the lung. Surg Case Rep. 2018;4(1):59.","journal-title":"Surg Case Rep"},{"issue":"1","key":"1196_CR6","first-page":"100","volume":"56","author":"A Sudirman","year":"2001","unstructured":"Sudirman A, Sukumar N, Davaraj B. Appendicular metastasis from carcinoma cervix. Med J Malays. 2001;56(1):100\u20131.","journal-title":"Med J Malays"},{"key":"1196_CR7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1634\/theoncologist.2002-0342","volume":"7","author":"M Friedlander","year":"2002","unstructured":"Friedlander M, Grogan M. Guidelines for the treatment of recurrent and metastatic cervical cancer. Oncologist. 2002;7:342\u20137.","journal-title":"Oncologist"},{"key":"1196_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0360-3016(92)90671-4","volume":"24","author":"H Fagundes","year":"1992","unstructured":"Fagundes H, Perez CA, Grigsby PW, Lockett MA. Distant metastases after irradiation alone in carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 1992;24:197\u2013204.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1196_CR9","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ygyno.2009.06.001","volume":"114","author":"E Laurie","year":"2009","unstructured":"Laurie E, Anthony WF, Michaela CD, Thomas KO, Michael FKF. Follow-up for women after treatment for cervical cancer: a systematic review. Gynecol Oncol. 2009;114(3):528\u201335.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"1196_CR10","first-page":"238","volume":"108","author":"K Takeshi","year":"2011","unstructured":"Takeshi K, Masahiro Y, Yosuke K, Hiroyuki M, Kentaro T, Yoyoma K, Shinsaku Y, Satoru T, Yasuji Y, Hironori S. Recurrent advanced gastric cancer diagnosed 20 years after partial gastrectomy. Nihon Shokakibyo Gakkai Zasshi. 2011;108(2):238\u201344.","journal-title":"Nihon Shokakibyo Gakkai Zasshi"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01196-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-021-01196-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01196-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T08:05:12Z","timestamp":1620374712000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-021-01196-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1196"],"URL":"https:\/\/doi.org\/10.1186\/s40792-021-01196-6","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"22 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was conducted in accordance with our institution\u2019s ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Informed consent for the publication of this work was provided by the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}