{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:00:06Z","timestamp":1768618806887,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Myotonic dystrophy (dystrophia myotonica [DM]) is an autosomal-dominant inheritance, and myasthenia gravis (MG) is an autoimmune disease characterized by weakness of skeletal muscles. Cases of both DM and MG are extremely rare and distinguishing DM and MG symptoms is challenging.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We herein report a 49-year-old woman presenting with subacute dyspnea and muscle weakness. She had previously been diagnosed with DM 24\u00a0years earlier. Computed tomography (CT) revealed an anterior mediastinal 32-mm solid mass that was suspected of being thymoma. The clinical features and neurological examination findings confirmed the diagnosis of thymoma-associated MG coexisting with DM. Intensive treatment for MG, including surgery, resulted in an improvement in some of her neurological symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The symptoms of DM usually progress slowly, so the sudden exacerbation of symptoms indicates the involvement of other factors. It is important to be aware of these associations, as an early diagnosis with proper treatment will result in a better outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-021-01223-6","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:02:29Z","timestamp":1625763749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report"],"prefix":"10.1186","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8158-1473","authenticated-orcid":false,"given":"Michiyo","family":"Miyawaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Jikumaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noda","family":"Daiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Anami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Osoegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sintaro","family":"Iwao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuro","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sugio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"1223_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/9781118635469.ch30","volume-title":"Muscle disease: pathology and genetics","author":"B Schoser","year":"2013","unstructured":"Schoser B. Myotonic dystrophies type 1 and 2. In: Goebel HH, Sewry CA, Weller RO, editors. Muscle disease: pathology and genetics. 2nd ed. Chichester: Wiley; 2013. p. 273\u201383.","edition":"2"},{"key":"1223_CR2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000369343","volume":"43","author":"A Theadom","year":"2014","unstructured":"Theadom A, Rodrigues M, Roxburgh R, Balalla S, Higgins C, Bhattacharjee R, et al. Prevalence of muscular dystrophies: a systematic literature review. Neuroepidemiology. 2014;43:259\u201368.","journal-title":"Neuroepidemiology"},{"key":"1223_CR3","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1001\/jama.2011.1796","volume":"306","author":"SM Gadalla","year":"2011","unstructured":"Gadalla SM, Lund M, Pfeiffer RM, G\u00f8rtz S, Mueller CM, Moxley RT, Kristinsson SY, Bj\u00f6rkholm M, Shebl FM, Hilbert JE, Landgren O. Cancer risk among patients with myotonic muscular dystrophy. JAMA. 2011;306:2480\u20136.","journal-title":"JAMA"},{"key":"1223_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.mayocp.2011.09.005","volume":"87","author":"AK Win","year":"2012","unstructured":"Win AK, Perattur PG, Pulido JS, Pulido CM, Lindor NM. Increased cancer risks in myotonic dystrophy. Mayo Clin Proc. 2012;87:130\u20135.","journal-title":"Mayo Clin Proc"},{"key":"1223_CR5","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s10552-009-9395-y","volume":"20","author":"CM Mueller","year":"2009","unstructured":"Mueller CM, Hilbert JE, Martens W, Thornton CA, Moxley RT 3rd, Greene MH. Hypothesis: neoplasms in myotonic dystrophy. Cancer Causes Control. 2009;20:2009\u201320.","journal-title":"Cancer Causes Control"},{"key":"1223_CR6","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/mus.21046","volume":"38","author":"T Feyma","year":"2008","unstructured":"Feyma T, Carter GT, Weiss MD. Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma. Muscle Nerve. 2008;38:916\u201320.","journal-title":"Muscle Nerve"},{"key":"1223_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.nmd.2013.09.001","volume":"24","author":"O Ekmekci","year":"2014","unstructured":"Ekmekci O, Karasoy H, Bademkiran F, Akkus DE, Yuceyar N. Myasthenia gravis and thymoma coexisting with myotonic dystrophy type 1. Neuromuscul Disord. 2014;24:40\u20132.","journal-title":"Neuromuscul Disord"},{"key":"1223_CR8","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1212\/WNL.49.6.1646","volume":"49","author":"J Mathieu","year":"1997","unstructured":"Mathieu J, Allard P, Gobeil G, Girard M, De Braekeleer M, B\u00e9gin P. Anesthetic and surgical complications in 219 cases of myotonic dystrophy. Neurology. 1997;49:1646\u201350.","journal-title":"Neurology"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01223-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-021-01223-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01223-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:02:55Z","timestamp":1625763775000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-021-01223-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1223"],"URL":"https:\/\/doi.org\/10.1186\/s40792-021-01223-6","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"30 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee in Oita University (Permission Number: 2032).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient provided informed consent for the publication of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"159"}}