{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:13:15Z","timestamp":1750479195766,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>A thymoma with chest pain and multilocular thymic cysts (MTCs) is very rare.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 49-year-old man presented to another hospital complaining of an anterior chest pain. Chest computed tomography (CT) showed an anterior mediastinal tumor 60\u2009\u00d7\u200930\u2009\u00d7\u200955\u00a0mm in size. The boundary with the pericardium or left brachiocephalic vein seemed to be partially unclear while enhanced by the contrast medium, and so the tumor could have invaded them. No definitive diagnosis of myasthenia gravis was made although the serum anti-acetylcholine receptor antibody count was high. We performed an extended thymectomy with combined partial resection of left brachiocephalic vein, left upper lobe, and left phrenic nerve. He was discharged with no chest pain and no complications post-surgery. The tumor was pathologically type B2 thymoma with hemorrhage necrosis and MTCs, and we diagnosed Masaoka stage II because of no histological infiltration to the organs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions <\/jats:title>\n                <jats:p>We speculated that hemorrhagic necrosis due to infarction in tumor caused the inflammation to spread to the surrounding organs, which was related to the chest pain and the development of MTCs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-021-01243-2","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T10:03:12Z","timestamp":1625738592000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of combined thymoma and a multilocular thymic cyst discovered due to chest pain"],"prefix":"10.1186","volume":"7","author":[{"given":"Kengo","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-4580","authenticated-orcid":false,"given":"Yoshiteru","family":"Kidokoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Makishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyuki","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nozaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Kubouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Haruki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"1243_CR1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.athoracsur.2006.02.082","volume":"82","author":"CD Wright","year":"2006","unstructured":"Wright CD, Wain JC. Acute presentation of thymoma with infarction or hemorrhage. Ann Thorac Surg. 2006;82:1901\u20134.","journal-title":"Ann Thorac Surg"},{"key":"1243_CR2","first-page":"629","volume":"26","author":"C Takasaki","year":"2012","unstructured":"Takasaki C, Ishibashi H, Fujiwara N, Akashi T, Okubo K. A case of thymoma with chest pain caused by bleeding necrosis. Nihon Kokyuki Geka Gakkai Zasshi (J Jpn Assoc Chest Surg). 2012;26:629\u201332 (in Japanese).","journal-title":"Nihon Kokyuki Geka Gakkai Zasshi (J Jpn Assoc Chest Surg)."},{"key":"1243_CR3","first-page":"476","volume":"68","author":"H Shiiya","year":"2015","unstructured":"Shiiya H, Sakuraba M, Tanaka A, Ishii Y, Fukazawa Y. Thymoma with hemorrhage and necrosis presenting with fever and chest pain; Report of a case. Kyobu Geka (Jpn J Thorac Surg). 2015;68:476\u20139 (in Japanese).","journal-title":"Kyobu Geka (Jpn J Thorac Surg.)"},{"key":"1243_CR4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/00000478-199104000-00008","volume":"15","author":"S Suster","year":"1991","unstructured":"Suster S, Rosai J. Multilocular thymic cyst: an acquired reactive process: study of 18 cases. Am J Surg Pathol. 1991;15:388\u201398.","journal-title":"Am J Surg Pathol"},{"key":"1243_CR5","first-page":"88","volume":"20","author":"H Itoh","year":"2006","unstructured":"Itoh H, Yamamoto T, Onuki T, Sakai M, Ishikawa S, Onizuka M, et al. A case of thymoma with spontaneous regression after rapid growth. 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Nihon Kokyuki Geka Gakkai Zasshi (J Jpn Assoc Chest Surg). 2011;25:74\u20138 (in Japanese).","journal-title":"Nihon Kokyuki Geka Gakkai Zasshi (J Jpn Assoc Chest Surg)"},{"key":"1243_CR8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00595-012-0436-x","volume":"44","author":"G Toyokawa","year":"2014","unstructured":"Toyokawa G, Taniguchi K, Ohba T, Hirai F, Yamaguchi M, Hamatake M, et al. Regression of thymoma associated with a multilocular thymic cyst: report of a case. Surg Today. 2014;44:577\u201380.","journal-title":"Surg Today"},{"key":"1243_CR9","first-page":"627","volume":"29","author":"E Kataoka","year":"2015","unstructured":"Kataoka E, Okamoto K, Oshio M, Motoishi M, Hanaoka J, Sawai S. A case of thymoma with extensive necrosis. 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