{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:14:30Z","timestamp":1787505270788,"version":"build-2736575974"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007962","name":"Jikei University School of Medicine","doi-asserted-by":"publisher","award":["2021-003SR"],"award-info":[{"award-number":["2021-003SR"]}],"id":[{"id":"10.13039\/501100007962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The intracystic papillary neoplasm (ICPN) is a newly established disease concept. It has been regarded as a preinvasive neoplastic lesion, similar to intraductal papillary mucinous neoplasm of the pancreas. Limited information is available on the clinical and imaging features of ICPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 65-year-old woman was referred to our hospital for assessment of a gallbladder tumor. Contrast-enhanced computed tomography showed a papillary tumor in the fundus of the gallbladder with irregular thickening of the gallbladder wall that spread into the cystic duct. The boundary between the tumor and liver was unclear. The patient was diagnosed with gallbladder cancer with liver invasion. We performed extended cholecystectomy with liver bed resection after confirming the absence of cancer cells in the resection margin of the cystic duct. After pathological examination, the tumor was diagnosed as an ICPN with xanthogranulomatous cholecystitis. The patient was discharged on postoperative day 8 with no complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have described a rare case of ICPN concomitant with xanthogranulomatous cholecystitis. Clinicians should include ICPN as a differential diagnosis in patients with a papillary or polypoid tumor in the gallbladder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40792-021-01312-6","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:02:40Z","timestamp":1635091360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intracystic papillary neoplasm of the gallbladder concomitant with xanthogranulomatous cholecystitis: a case report"],"prefix":"10.1186","volume":"7","author":[{"given":"Takashi","family":"Aida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-1801","authenticated-orcid":false,"given":"Masashi","family":"Tsunematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenei","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Onda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Gomisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"1312_CR1","unstructured":"WHO Classification of Tumours Editorial Board Digestive system tumours Lyon (France) International Agency for Research on Cancer. WHO classification of tumours series. (5th ed) 2019;1."},{"key":"1312_CR2","first-page":"1136","volume":"10","author":"O Ewelukwa","year":"2013","unstructured":"Ewelukwa O, Ali O, Akram S. Xanthogranulomatous cholecystitis mimicking gallbladder cancer. BMJ Case Rep. 2013;10:1136.","journal-title":"BMJ Case Rep"},{"key":"1312_CR3","first-page":"266","volume-title":"WHO classification of tumours of the digestive system","author":"J Albores-Saavedra","year":"2010","unstructured":"Albores-Saavedra J, Adsay NV, Crawford JM, et al. Carcinoma of the gallbladder and extrahepatic ducts. In: Bosman FT, Carneiro F, Hruban RH, et al., editors. WHO classification of tumours of the digestive system. 4th ed. Lyon: International Agency for Research on Cancer; 2010. p. 266\u201373.","edition":"4"},{"key":"1312_CR4","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1097\/PAS.0b013e318262787c","volume":"36","author":"V Adsay","year":"2012","unstructured":"Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, et al. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are \u2265 1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases. Am J Surg Pathol. 2012;36:1279\u2013301.","journal-title":"Am J Surg Pathol"},{"key":"1312_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s12328-020-01233-1","volume":"14","author":"T Oba","year":"2021","unstructured":"Oba T, Sato N, Tamura T, Komeda M, Adachi Y, Matsuyama A, et al. A case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production. Clin J Gastroenterol. 2021;14:319\u201324.","journal-title":"Clin J Gastroenterol"},{"key":"1312_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1177\/1066896916644781","volume":"24","author":"A Argon","year":"2016","unstructured":"Argon A, Barbet FY, Nart D. The relationship between intracholecystic papillary-tubular neoplasms and invasive carcinomas of gallbladder. Int J Surg Pathol. 2016;24:504\u201311.","journal-title":"Int J Surg Pathol"},{"key":"1312_CR7","doi-asserted-by":"publisher","first-page":"e363","DOI":"10.1097\/RLU.0000000000003442","volume":"46","author":"R Ismail","year":"2021","unstructured":"Ismail R, Saeed Bamashmos A, Cohen PJ, Pucar D. Intracystic papillary neoplasm of gallbladder mimicking metastatic malignancy on PET\/CT. Clin Nucl Med. 2021;46:e363\u20134.","journal-title":"Clin Nucl Med"},{"key":"1312_CR8","first-page":"e929788","volume":"22","author":"L Ana","year":"2021","unstructured":"Ana L, Julio C, Carlos D, Jorge P, Maria TC, Carlos C. Low-grade dysplastic intracholecystic papillary neoplasia. Am J Case Rep. 2021;22:e929788.","journal-title":"Am J Case Rep."},{"key":"1312_CR9","doi-asserted-by":"publisher","first-page":"e00574","DOI":"10.14309\/crj.0000000000000574","volume":"8","author":"N Kuniyoshi","year":"2021","unstructured":"Kuniyoshi N, Imazu H, Hayama J, Nomura S, Kagawa A, Hamana S, et al. Intracholecystic papillary neoplasm of the gallbladder preoperative diagnosed by endoscopic ultrasonography and peroral cholangioscopy. ACG Case Rep J. 2021;8:e00574.","journal-title":"ACG Case Rep J."},{"key":"1312_CR10","first-page":"488","volume":"11","author":"M Yokode","year":"2019","unstructured":"Yokode M, Hanada K, Shimizu A, Minami T, Hirohata R, Amano H, et al. Intracholecystic papillary neoplasm of the gallbladder protruding into the common bile duct. 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Surg Endosc. 2021;35:3874\u201380.","journal-title":"Surg Endosc"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01312-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-021-01312-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-021-01312-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:09:30Z","timestamp":1635091770000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-021-01312-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1312"],"URL":"https:\/\/doi.org\/10.1186\/s40792-021-01312-6","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]},"assertion":[{"value":"2 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study meeting the ethical standards of the World Medical Association Declaration of Helsinki was approved by The Jikei University School of Medicine [27-177(8062)].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient has given consent for the publication of images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"229"}}