{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:40:30Z","timestamp":1761514830239,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Intraductal papillary neoplasm of the bile duct (IPNB) is a subtype of biliary tumor. The 5-year survival rate of patients with IPNB who underwent curative resection is 81%. However, IPNB is known to often recur in other parts of the bile duct. Nevertheless, its mechanism remains poorly understood. Herein, we report the case of a patient with recurrent IPNB, which was considered to be attributed to intraductal dissemination in the common bile duct at 12\u00a0months after curative resection. We also made a review of the existing literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 69-year-old man was referred to our hospital for the evaluation and dilation of an intrahepatic bile duct (IHBD) mass. Computed tomography (CT) findings confirmed a mass in the left hepatic duct. Left trisectionectomy, extrahepatic bile duct resection with biliary reconstruction, and regional lymph node dissection were performed. Intraoperative examination of the resection margin at the common bile duct and posterior segmental branch of the hepatic duct was negative for the presence of malignant cells. Histologically, the tumor showed intraductal papillary growth of the mucinous epithelium and was diagnosed as non-invasive IPNB. It had a papillary structure with atypical epithelial cells lined up along the neoplastic fibrovascular stalks. Immunohistochemically, this was as a gastric-type lesion. At 12 postoperative months, CT revealed a 1.5-cm mass in the lower remnant common bile duct. We performed subtotal stomach-preserving pancreaticoduodenectomy. The tumor exhibited papillary growth and was microscopically and immunohistochemically similar to the first tumor. At approximately 16\u00a0months after the patient\u2019s second discharge, CT showed an abdominal mass at the superior mesenteric plexus, which was diagnosed as recurrent IPNB. Chemotherapy is ongoing, and the patient is still alive. In this case, as described in many previous reports, IPNB recurred below the primary lesion in the bile duct.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Based on our review of previous reports on IPNB recurrence, intraductal dissemination was considered one of the mechanisms underlying recurrence after multicentric development. Considering the high frequency and oncological conversion of recurrence in IPNB, regular follow-up examination is essential to achieve better prognosis in patients with recurrent IPNB.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-021-01318-0","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T12:02:40Z","timestamp":1636113760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recurrent intraductal papillary neoplasm of the bile duct due to intraductal dissemination: a case report and literature review"],"prefix":"10.1186","volume":"7","author":[{"given":"Yuki","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-2604","authenticated-orcid":false,"given":"Takahiro","family":"Tomino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Minagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Minami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"issue":"5","key":"1318_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.ejso.2018.10.532","volume":"45","author":"F Harada","year":"2019","unstructured":"F Harada R Matsuyama R Mori T Kumamoto D Morioka M Taguri  2019 Outcomes of surgery for 2010 WHO classification-based intraductal papillary neoplasm of the bile duct: case-control study of a single Japanese institution\u2019s experience with special attention to mucin expression patterns Eur J Surg Oncol 45 5 761 768","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"1318_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.14701\/kjhbps.2012.16.4.138","volume":"16","author":"GW Jang","year":"2012","unstructured":"GW Jang S Hwang YJ Lee KH Kim KM Park CS Ahn  2012 Clinicopathological features of the intraductal papillary neoplasms of the intrahepatic bile duct Korean J Hepatob Pancreat Surg 16 4 138 141","journal-title":"Korean J Hepatob Pancreat Surg"},{"issue":"5","key":"1318_CR3","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/hep.21387","volume":"44","author":"Y Zen","year":"2006","unstructured":"Y Zen T Fujii K Itatsu K Nakamura H Minato S Kasashima  2006 Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas Hepatology 44 5 1333 1343","journal-title":"Hepatology"},{"issue":"46","key":"1318_CR4","doi-asserted-by":"publisher","first-page":"8595","DOI":"10.3748\/wjg.v19.i46.8595","volume":"19","author":"XS Wan","year":"2013","unstructured":"XS Wan YY Xu JY Qian XB Yang AQ Wang L He  2013 Intraductal papillary neoplasm of the bile duct World J Gastroenterol 19 46 8595 8604","journal-title":"World J Gastroenterol"},{"issue":"4","key":"1318_CR5","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/cncr.20031","volume":"100","author":"SS Lee","year":"2004","unstructured":"SS Lee MH Kim SK Lee SJ Jang MH Song KP Kim  2004 Clinicopathologic review of 58 patients with biliary papillomatosis Cancer 100 4 783 793","journal-title":"Cancer"},{"issue":"4","key":"1318_CR6","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1002\/hep.25786","volume":"56","author":"FG Rocha","year":"2012","unstructured":"FG Rocha H Lee N Katabi RP DeMatteo Y Fong MI D\u2019Angelica  2012 Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? 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Informed consent to participate was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"238"}}