{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:50:03Z","timestamp":1768549803618,"version":"3.49.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gastric cancer rarely metastasizes to the gallbladder. Furthermore, there has never been a case report of simultaneous gallbladder metastasis from residual gastric cancer. Here, we report a case of synchronous gallbladder metastasis originating from a residual gastric cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 67-year-old man underwent a follow-up upper endoscopy 18\u00a0months after a partial gastrectomy for gastric cancer; an ulcerative lesion was found in the remnant stomach at the gastrojejunal anastomosis. A biopsy revealed gastric signet-ring cell carcinoma (SRCC). A full-body examination revealed no abnormalities other than gallstones in the gallbladder. With a diagnosis of residual gastric cancer (cT2N0M0 cStage I), the patient underwent open total gastrectomy and cholecystectomy. Macroscopic findings of the resected specimen revealed thickening of the gallbladder wall; however, no obvious neoplastic lesions were found on the mucosal surface of the gallbladder. The pathological findings showed that the SRCC had invaded the submucosa of the gastrojejunostomy site with a high degree of lymphatic invasion and lymph node metastases. SRCCs were also found in the lymphatic vessels of the gallbladder wall. These findings suggested the possibility of gallbladder metastasis through lymphatic vessels. The patient and his family members refused postoperative chemotherapy. Ten months after the operation, the patient experienced respiratory failure due to lymphangitis carcinomatosa and died.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>At present, it is difficult to determine whether resection of the gallbladder contributes to an improved prognosis of gastric cancer patients. However, reports in such cases demonstrate that gallbladder metastasis could be a poor predictor of prognosis for gastric cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-022-01442-5","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:02:37Z","timestamp":1651928557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synchronous gallbladder metastasis originating from residual gastric cancer: a case report and the review of literature"],"prefix":"10.1186","volume":"8","author":[{"given":"Ami","family":"Kawamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-4135","authenticated-orcid":false,"given":"Koichi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Minagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Minami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"1442_CR1","first-page":"376","volume":"47","author":"Y Muta","year":"2020","unstructured":"Muta Y, Mochiki E, Kumakura M, Toyomasu Y, Ishiguro T, Kumagai Y, et al. A case of synchronous gallbladder metastasis originating from advanced gastric cancer. Gan To Kagaku Ryoho. 2020;47:376\u20138.","journal-title":"Gan To Kagaku Ryoho"},{"key":"1442_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3109\/00313028809085191","volume":"20","author":"KW Chan","year":"1988","unstructured":"Chan KW. Review of 253 cases of significant pathology in 7,910 cholecystectomies in Hong Kong. Pathology. 1988;20:20\u20133. https:\/\/doi.org\/10.3109\/00313028809085191.","journal-title":"Pathology"},{"key":"1442_CR3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3348\/kjr.2014.15.3.334","volume":"15","author":"WS Choi","year":"2014","unstructured":"Choi WS, Kim SH, Lee ES, Lee KB, Yoon WJ, Shin CII, et al. CT findings of gallbladder metastases: emphasis on differences according to primary tumors. Korean J Radiol. 2014;15:334\u201345. https:\/\/doi.org\/10.3348\/kjr.2014.15.3.334.","journal-title":"Korean J Radiol"},{"key":"1442_CR4","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.3748\/wjg.15.4806","volume":"15","author":"WJ Yoon","year":"2009","unstructured":"Yoon WJ, Yoon YB, Kim YJ, Ryu JK, Kim YT. Metastasis to the gallbladder: a single-center experience of 20 cases in South Korea. World J Gastroenterol. 2009;15:4806\u20139. https:\/\/doi.org\/10.3748\/wjg.15.4806.","journal-title":"World J Gastroenterol"},{"key":"1442_CR5","volume-title":"Japanese classification of gastric carcinoma","author":"Japanese Gastric Cancer Association","year":"2017","unstructured":"Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma. 15th ed. 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