{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:52:53Z","timestamp":1788457973469,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Rectal neuroendocrine neoplasms can induce liver metastasis. However, few reports exist on the associated long-term recurrence rates. We report a case of liver metastasis identified 15\u00a0years after rectal neuroendocrine neoplasm resection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 50-year-old woman was on semi-annual follow-up after undergoing mastectomy for breast cancer (pT1N0M0) and low anterior resection for grade 1 rectal neuroendocrine neoplasm (pT1b, ly1, v1). Fifteen years postoperatively, a 7-mm hyperechoic mass was identified at liver segment 6. Magnetic resonance imaging revealed a slight growth of the mass. Positron emission tomography\/computed tomography revealed radiotracer accumulation in the lesion. Laparoscopic hepatectomy was performed. The histopathological diagnosis was grade 2 neuroendocrine neoplasm. The pathological findings and clinical course indicated the tumor originated in the rectum.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings highlight the need to reassess the optimal postoperative follow-up period for patients with rectal neuroendocrine neoplasm.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-022-01569-5","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T09:27:25Z","timestamp":1669973245000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liver metastasis from rectal neuroendocrine neoplasm detected 15\u00a0years after primary resection"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-5730","authenticated-orcid":false,"given":"Miho","family":"Akabane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Kinowaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Shindoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"1569_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000443166","volume":"103","author":"JK Ramage","year":"2016","unstructured":"Ramage JK, De Herder WW, Delle Fave G, Ferolla P, Ferone D, Ito T, et al. ENETS consensus guidelines update for colorectal neuroendocrine neoplasms. Neuroendocrinology. 2016;103:139\u201343.","journal-title":"Neuroendocrinology"},{"key":"1569_CR2","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/cncr.11105","volume":"97","author":"IM Modlin","year":"2003","unstructured":"Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934\u201359.","journal-title":"Cancer"},{"key":"1569_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1245\/ASO.2003.04.533","volume":"10","author":"CD Knox","year":"2003","unstructured":"Knox CD, Anderson CD, Lamps LW, Adkins RB, Pinson CW. Long-term survival after resection for primary hepatic carcinoid tumor. Ann Surg Oncol. 2003;10:1171\u20135.","journal-title":"Ann Surg Oncol"},{"key":"1569_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00004728-199201000-00018","volume":"16","author":"K Takayasu","year":"1992","unstructured":"Takayasu K, Muramatsu Y, Sakamoto M, Mizuguchi Y, Moriyama N, Wakao F, et al. Findings in primary hepatic carcinoid tumor: US, CT, MRI, and angiography. J Comput Assist Tomogr. 1992;16:99\u2013102.","journal-title":"J Comput Assist Tomogr"},{"key":"1569_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40792-020-0792-5","volume":"6","author":"Y Hane","year":"2020","unstructured":"Hane Y, Tsuchikawa T, Tanaka K, Nakanishi Y, Asano T, Noji T, et al. Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases. Surg Case Rep. 2020;6:22.","journal-title":"Surg Case Rep"},{"key":"1569_CR6","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.2169\/internalmedicine.56.7547","volume":"56","author":"Y Shigematsu","year":"2017","unstructured":"Shigematsu Y, Kanda H, Konishi T, Takazawa Y, Inoue Y, Muto T, et al. Recurrence 30 years after surgical resection of a localized rectal neuroendocrine tumor. Intern Med. 2017;56:1521\u20135.","journal-title":"Intern Med"},{"key":"1569_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/archsurg.143.5.471","volume":"143","author":"MR Kwaan","year":"2008","unstructured":"Kwaan MR, Goldberg JE, Bleday R. Rectal carcinoid tumors: review of results after endoscopic and surgical therapy. Arch Surg. 2008;143:471\u20135.","journal-title":"Arch Surg"},{"key":"1569_CR8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1245\/s10434-006-9197-3","volume":"14","author":"BN Fahy","year":"2007","unstructured":"Fahy BN, Tang LH, Klimstra D, Wong WD, Guillem JG, Paty PB, et al. Carcinoid of the rectum risk stratification (CaRRS): a strategy for preoperative outcome assessment. Ann Surg Oncol. 2007;14:396\u2013404.","journal-title":"Ann Surg Oncol"},{"key":"1569_CR9","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology neuroendocrine tumors version 1; 2015. http:\/\/www.iqanda-cme.com\/assets\/pdf\/NCCN%20Guidelines_Neuroendocrine%20Tumors.pdf."},{"key":"1569_CR10","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1007\/s00464-015-4735-3","volume":"30","author":"S Sugimoto","year":"2016","unstructured":"Sugimoto S, Hotta K, Shimoda T, Imai K, Yamaguchi Y, Nakajima T, et al. The Ki-67 labeling index and lymphatic\/venous permeation predict the metastatic potential of rectal neuroendocrine tumors. Surg Endosc. 2016;30:4239\u201348.","journal-title":"Surg Endosc"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-022-01569-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-022-01569-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-022-01569-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T09:30:10Z","timestamp":1669973410000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-022-01569-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1569"],"URL":"https:\/\/doi.org\/10.1186\/s40792-022-01569-5","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,2]]},"assertion":[{"value":"24 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient for the publication of this case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"212"}}