{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:18:30Z","timestamp":1775060310911,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Anorectal fistula cancer is often diagnosed in an advanced state, and radical resection is difficult when invasion of the pelvic wall is observed. In addition, there is currently no clear evidence for perioperative treatment of locally advanced cases. We report a case of anorectal fistula cancer with widespread infiltration diagnosed during the course of Crohn\u2019s disease, which was curatively resected after preoperative chemoradiotherapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 49-year-old man who had been diagnosed with Crohn\u2019s disease (ileocolonic type) at the age of 25 and was found to have an anorectal fistula and perianal abscess at the age of 44 was referred to our department with complaints of abdominal pain and diarrhea. Computed tomography (CT) showed anal stenosis due to a pelvic mass. Pathological analysis of a biopsy taken under general anesthesia indicated mucinous carcinoma. Magnetic resonance imaging (MRI) revealed infiltration into the prostate, seminal vesicles, levator ani muscle, and left internal obturator muscle, and the patient was diagnosed with cT4N0M0 cStage IIIB anorectal fistula cancer (UICC TNM classification 8th edition). After performing a laparoscopic sigmoid colostomy, chemoradiation therapy (capecitabine\u2009+\u2009oxaliplatin, 50.4\u00a0Gy\/28fr) was initiated. The patient then underwent laparoscopic total pelvic exenteration, colonic conduit diversion, extensive perineal resection, and reconstruction using bilateral gluteus maximus flaps and a right rectus abdominis musculocutaneous flap. The pathological diagnosis was mucinous adenocarcinoma, pT4, and all margins were negative. No recurrence was evident 6\u00a0months after the operation without adjuvant chemotherapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We described a case of curative resection after preoperative chemoradiotherapy for anorectal fistula cancer with extensive invasion that was diagnosed during the course of Crohn\u2019s disease.An accumulation of cases is needed to determine the usefulness of preoperative chemoradiation therapy for local control of anorectal fistula cancer associated with Crohn\u2019s disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-023-01778-6","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:02:24Z","timestamp":1699956144000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resection of anorectal fistula cancer associated with Crohn\u2019s disease after preoperative chemoradiotherapy: a case report"],"prefix":"10.1186","volume":"9","author":[{"given":"Takuya","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-0047","authenticated-orcid":false,"given":"Yuki","family":"Sekido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikatsu","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunekazu","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"1778_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3862\/jcoloproctology.58.415","volume":"58","author":"S Sameshima","year":"2005","unstructured":"Sameshima S, Sawada T, Nagasako K. Squamous cell carcinoma of anus and carcinoma in association with anal fistula in Japan, multi-institutional registration. J Jpn Soc Coloproctol. 2005;58:415\u201321.","journal-title":"J Jpn Soc Coloproctol"},{"key":"1778_CR2","volume-title":"TNM classification of malignant tumours","author":"JDGM Brieley","year":"2016","unstructured":"Brieley JDGM, Wittekind C. TNM classification of malignant tumours. Wiley: Blackwell; 2016."},{"key":"1778_CR3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228\u201347.","journal-title":"Eur J Cancer."},{"key":"1778_CR4","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1002\/1097-0142(19940601)73:11<2680::AID-CNCR2820731105>3.0.CO;2-C","volume":"73","author":"AM Mandard","year":"1994","unstructured":"Mandard AM, Dalibard F, Mandard JC, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Cancer. 1994;73:2680\u20136.","journal-title":"Cancer"},{"key":"1778_CR5","volume-title":"WHO classification of tumours of the digestive system, volume 3","author":"FT Bosman","year":"2010","unstructured":"Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system, volume 3. 4th ed. Lyon: International Agency for Research on Cancer; 2010.","edition":"4"},{"key":"1778_CR6","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/BF01308045","volume":"25","author":"S Traube Jm Sinpson","year":"1980","unstructured":"Traube Jm Sinpson S, Ridell RH, et al. Crohn\u2019s disease and adenocarcinoma of the bowel. Dig Dis Sci. 1980;25:939\u201344.","journal-title":"Dig Dis Sci."},{"key":"1778_CR7","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/milmed\/151.10.543","volume":"15","author":"DJ Abramson","year":"1986","unstructured":"Abramson DJ. Perianal mucinous adenocarcinoma and fistula-in-ano. Mil Med. 1986;15:543\u20136.","journal-title":"Mil Med"},{"key":"1778_CR8","first-page":"555","volume":"38","author":"K Okada","year":"2008","unstructured":"Okada K, Shatari T, Sasaki T, et al. Is histopathological evidence really essential for making a surgical decision about mucinous carcinoma arising in a perianal fistula? Rep Case Surg Today. 2008;38:555\u20138.","journal-title":"Rep Case Surg Today"},{"key":"1778_CR9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S0002-9610(31)90665-X","volume":"11","author":"C Rosser","year":"1931","unstructured":"Rosser C. The etiology of anal cancer. Am J Surg. 1931;11:328\u201333.","journal-title":"Am J Surg"},{"key":"1778_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0002-9610(48)90307-9","volume":"75","author":"I Skir","year":"1948","unstructured":"Skir I. Mucinous adenocarcinoma associated with fistulas of long-standing. Am J Surg. 1948;75:285\u20139.","journal-title":"Am J Surg"},{"key":"1778_CR11","first-page":"66","volume":"54","author":"A Sugita","year":"2012","unstructured":"Sugita A, Koganei K, Tatsumi K, et al. Optimal diagnosis for fistula-associated anal cancer with Crohn\u2019s disease. Gastroenterol Endosc. 2012;54:66\u201372.","journal-title":"Gastroenterol Endosc"},{"key":"1778_CR12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3862\/jcoloproctology.61.353","volume":"61","author":"M Shinozaki","year":"2008","unstructured":"Shinozaki M. Crohn\u2019s disease and intestinal cancer in Japan. J Jpn Soc Coloproctol. 2008;61:353\u201363.","journal-title":"J Jpn Soc Coloproctol"},{"key":"1778_CR13","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/ecco-jcc\/jjv141","volume":"9","author":"V Annese","year":"2015","unstructured":"Annese V, Beaugerie L, Egan L, et al. European evidence-based consensus: inflammatory bowel disease and malignancies. J Crohns Colitis. 2015;9:945\u201365.","journal-title":"J Crohns Colitis"},{"key":"1778_CR14","first-page":"3761","volume":"36","author":"D Higashi","year":"2016","unstructured":"Higashi D, Katsuno H, Kimura H, et al. Current state of and problems related to cancer of the intestinal tract associated with Crohn\u2019s disease in Japan. Anticancer Res. 2016;36:3761\u20136.","journal-title":"Anticancer Res"},{"key":"1778_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.23922\/jarc.2018-005","volume":"2","author":"Y Hirano","year":"2018","unstructured":"Hirano Y, Futami K, Higashi D, et al. Anorectal cancer surveillance in Crohn\u2019s disease. J Anus Rectum Colon. 2018;2:145\u201354.","journal-title":"J Anus Rectum Colon"},{"key":"1778_CR16","first-page":"962","volume":"77","author":"E Sunami","year":"2022","unstructured":"Sunami E, et al. Diagnosis and surgical treatment for carcinoma associated with anal fistula. J Clin Surg. 2022;77:962\u20136.","journal-title":"J Clin Surg"},{"key":"1778_CR17","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1093\/annonc\/mdi244","volume":"16","author":"FV Negri","year":"2005","unstructured":"Negri FV, Wotherspoon A, Cunningham D, et al. Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer. Ann Oncol. 2005;16:1305\u201310.","journal-title":"Ann Oncol"},{"key":"1778_CR18","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/sj.bjc.6604955","volume":"100","author":"V Catalano","year":"2009","unstructured":"Catalano V, Loupakis F, Graziano F, et al. Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin-and\/or irinotecan-based chemotherapy. Br J Cancer. 2009;100:881\u20137.","journal-title":"Br J Cancer"},{"key":"1778_CR19","first-page":"1392","volume":"45","author":"K Matsuda","year":"2010","unstructured":"Matsuda K, Akabane T, Shimada R, et al. Fistula cancer, report of a case. Stomach Intest. 2010;45:1392\u20138.","journal-title":"Stomach Intest"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-023-01778-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-023-01778-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-023-01778-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:02:38Z","timestamp":1699956158000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-023-01778-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1778"],"URL":"https:\/\/doi.org\/10.1186\/s40792-023-01778-6","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"11 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institutional ethics committee determined that approval was not necessary for a case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethic approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient to publish this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"197"}}