{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:54:28Z","timestamp":1740174868881,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>CA15-3 is often elevated in breast cancer recurrence and rarely in ductal carcinoma in situ (DCIS). We report a case of DCIS with elevated CA15-3 levels, which was diagnosed after over 2 years of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 74-year-old woman presented with a left-sided breast mass and pain. Redness, swelling, and induration were observed in the left breast. Ultrasonography revealed a non-mass lesion in the left 3 o'clock position, skin thickening, and axillary lymphadenopathy. Serum CA15-3 levels were markedly high at 640 U\/mL, suggesting inflammatory breast cancer. However, biopsies showed no malignancy. We diagnosed chronic mastitis with elevated CA15-3 levels and followed up with magnetic resonance imaging and a biopsy, as needed. Finally, DCIS was diagnosed 27\u00a0months after the first visit. She underwent a left mastectomy and a sentinel lymph node biopsy; DCIS had spread 6.5\u00a0cm and was immunohistochemically positive for CA15-3. No metastasis was found in the lymph nodes, but incidental Hodgkin lymphoma was observed. Postoperative normalization of CA15-3 levels indicated that she had DCIS with elevated CA15-3 levels. The patient underwent chemotherapy for Hodgkin lymphoma postoperatively, and there was no evidence of recurrence 1\u00a0year after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>High CA15-3 levels can also be observed in DCIS, indicating that CA15-3 should not be used solely in breast cancer staging.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-023-01792-8","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T03:02:23Z","timestamp":1701399743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of ductal carcinoma in situ (DCIS) with markedly elevated CA15-3 levels requiring 2 years of diagnosis"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-2854","authenticated-orcid":false,"given":"Mutsumi","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Kuraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yoshiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Shigematu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"1792_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1373\/clinchem.2005.059832","volume":"52","author":"MJ Duffy","year":"2006","unstructured":"Duffy MJ. Serum tumor markers in breast cancer: are they of clinical value? Clin Chem. 2006;52:345\u201351. https:\/\/doi.org\/10.1373\/clinchem.2005.059832.","journal-title":"Clin Chem"},{"key":"1792_CR2","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/bjc.1991.179","volume":"63","author":"M Gion","year":"1991","unstructured":"Gion M, Mione R, Nascimben O, Valsecchi M, Gatti C, Leon A, et al. The tumour associated antigen CA15.3 in primary breast cancer. Evaluation of 667 cases. Br J Cancer. 1991;63:809\u201313. https:\/\/doi.org\/10.1038\/bjc.1991.179.","journal-title":"Br J Cancer"},{"key":"1792_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133830","volume":"10","author":"Y Shao","year":"2015","unstructured":"Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parameters for different molecular subtypes of breast cancer. 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Jpn J Clin Surg. 2015;76:2105\u201310. https:\/\/doi.org\/10.3919\/JJSA.76.2105.","journal-title":"Jpn J Clin Surg"},{"key":"1792_CR8","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/carcin\/bgaa082","volume":"41","author":"DW Kufe","year":"2020","unstructured":"Kufe DW. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis. 2020;41:1173\u201383. https:\/\/doi.org\/10.1093\/carcin\/bgaa082.","journal-title":"Carcinogenesis"},{"key":"1792_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/(sici)1097-0215(19991022)84:5<466::aid-ijc3>3.0.co;2-#","volume":"84","author":"ECM Mommers","year":"1999","unstructured":"Mommers ECM, Leonhart AM, von Mensdorff-Pouilly S, Schol DJ, Hilgers J, Meijer CJLM, et al. Aberrant expression of muc1 mucin in ductal hyperplasia and ductal carcinoma in situ of the breast. 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J int Med Res. 2015;43:599\u2013609. https:\/\/doi.org\/10.1177\/0300060515583076.","journal-title":"J int Med Res"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-023-01792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-023-01792-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-023-01792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T03:06:06Z","timestamp":1701399966000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-023-01792-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1792"],"URL":"https:\/\/doi.org\/10.1186\/s40792-023-01792-8","relation":{},"ISSN":["2198-7793"],"issn-type":[{"type":"electronic","value":"2198-7793"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"assertion":[{"value":"24 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were performed in accordance with the ethical standards of the appropriate version of the Declaration of Helsinki. Ethical committee approval was not required for this case report. Patient anonymity was preserved, and personal information was protected.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No potential conflicts of interest were disclosed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}