{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:14:10Z","timestamp":1770495250504,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Nipple adenoma is a relatively rare benign disease. Clinically, it often presents with nipple erosions, and it should be differentiated from Paget\u2019s disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The patient was a 63-year-old woman who complained of a lump in her left nipple for more than 30\u00a0years. Computed tomography performed for screening congestive heart failure suggested a left nipple mass of 40\u00a0mm in size. Needle biopsy revealed nipple adenoma, and skin biopsy was also performed to confirm the diagnosis. Nipple tumor resection was performed under local anesthesia, and we confirmed that the final diagnosis was nipple adenoma with negative margins. The patient has been free from recurrence for 2\u00a0years since the surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We have reported our experience of a case of giant nipple adenoma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01869-y","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T08:01:51Z","timestamp":1711353711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of giant nipple adenoma"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5163-5444","authenticated-orcid":false,"given":"Shuko","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masumi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuteru","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Satou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"issue":"3","key":"1869_CR1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.5795\/jjscc.29.434","volume":"29","author":"A Ishihara","year":"1990","unstructured":"Ishihara A, Koyama H, Uemori A, et al. Aspiration cytology on a case of adenoma of the nipple. J Jpn Soc Clin Cytol. 1990;29(3):434\u20138.","journal-title":"J Jpn Soc Clin Cytol"},{"key":"1869_CR2","first-page":"562","volume":"57","author":"I Sakumoto","year":"1996","unstructured":"Sakumoto I, Kudaka H, Yamashiro K, et al. A case of adenoma of the nipple. J Japan Surg Assoc. 1996;57:562\u20136.","journal-title":"J Japan Surg Assoc"},{"issue":"6","key":"1869_CR3","first-page":"460","volume":"22","author":"A Sugamata","year":"2002","unstructured":"Sugamata A, Shigehara K, Miyashita K. Adenoma of the nipple of the mammary gland (adenoma of the nipple): a case report and a summary of cases reported in Japan. J Japan Soc Plast Reconstr Surg. 2002;22(6):460\u20135.","journal-title":"J Japan Soc Plast Reconstr Surg"},{"issue":"1","key":"1869_CR4","first-page":"56","volume":"27","author":"N Uchida","year":"2010","unstructured":"Uchida N, Suda T, Ishiguro S, et al. A case of adenoma of the nipple and the result about reports in Japan. Endocr Surg. 2010;27(1):56\u201360.","journal-title":"Endocr Surg"},{"issue":"4 Suppl 1","key":"1869_CR5","doi-asserted-by":"publisher","first-page":"s17","DOI":"10.1590\/S0365-05962011000700003","volume":"86","author":"MS Cosechen","year":"2011","unstructured":"Cosechen MS, Wojcik AS, Piva FM, et al. Erosive adenomatosis of the nipple. An Bras Dermatol. 2011;86(4 Suppl 1):s17\u201320.","journal-title":"An Bras Dermatol"},{"issue":"1","key":"1869_CR6","first-page":"81","volume":"18","author":"H Nishimura","year":"2003","unstructured":"Nishimura H, Shiina T, Uchikawa Y, et al. A case of adenoma of the nipple initially identified as breast cancer by aspiration biopsy cytology. Jpn J Breast Cancer. 2003;18(1):81\u20134.","journal-title":"Jpn J Breast Cancer"},{"issue":"2","key":"1869_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00000478-198602000-00002","volume":"10","author":"PP Rosen","year":"1986","unstructured":"Rosen PP, Caicco JA. Florid papillomatosis of the nipple. A study of 51 patients, including nine with mammary carcinoma. Am J Surg Pathol. 1986;10(2):87\u2013101.","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1869_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1075-122X.2004.21518.x","volume":"10","author":"E Carter","year":"2004","unstructured":"Carter E, Dyess D. Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. Breast J. 2004;10(5):443\u20137.","journal-title":"Breast J"},{"issue":"12","key":"1869_CR9","first-page":"1071","volume":"44","author":"K Takada","year":"2017","unstructured":"Takada K, Kashiwagi S, Goto W, et al. A case of adenoma of the nipple suspected of breast cancer. Jpn J Cancer Chemother. 2017;44(12):1071\u20133.","journal-title":"Jpn J Cancer Chemother"},{"issue":"2","key":"1869_CR10","first-page":"259","volume":"14","author":"S Takao","year":"1999","unstructured":"Takao S, Sakamoto G, Kasumi F, et al. Adenoma of the nipple. Clinical and pathologic features in six cases. Jpn J Breast Cancer. 1999;14(2):259\u201364.","journal-title":"Jpn J Breast Cancer"},{"issue":"11","key":"1869_CR11","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3919\/jjsa.73.2763","volume":"73","author":"S Kashiwagi","year":"2012","unstructured":"Kashiwagi S, Sakimura C, Kawajiri H, et al. Five cases of Paget\u02bcs disease of the breast. J Japan Surg Assoc. 2012;73(11):2763\u20137.","journal-title":"J Japan Surg Assoc"},{"issue":"1","key":"1869_CR12","first-page":"69","volume":"34","author":"H Watanabe","year":"1991","unstructured":"Watanabe H, Kitamura R. A case of adenoma of the nipple. Skin Res. 1991;34(1):69\u201373.","journal-title":"Skin Res"},{"key":"1869_CR13","first-page":"573","volume":"17","author":"A Batistatou","year":"2003","unstructured":"Batistatou A, Stefanou D, Arkoumani E, Agnantis NJ. The usefulness of p63 as a marker of breast myoepithelial cells. In Vivo. 2003;17:573\u20136.","journal-title":"In Vivo"},{"key":"1869_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.5858\/2010-0336-CP.1","volume":"135","author":"R Dewar","year":"2011","unstructured":"Dewar R, Fadare O, Gilmore H, Gown AM. Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology. Arch Pathol Lab Med. 2011;135:422\u20139.","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"1869_CR15","first-page":"211","volume":"17","author":"P Scott","year":"1991","unstructured":"Scott P, Kissin MW, Collins C, et al. Florid papillomatosis of the nipple: aclinico-pathological surgical problem. Eur J Surg Oncol. 1991;17(2):211\u20133.","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"1869_CR16","first-page":"639","volume":"50","author":"LL Vianna","year":"1993","unstructured":"Vianna LL, Millis RR, Fentiman IS. Adenoma of the nipple: a diagnostic dilemma. Br J Hosp Med. 1993;50(11):639\u201342.","journal-title":"Br J Hosp Med"},{"issue":"1","key":"1869_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3804\/jjabcs.19.67","volume":"19","author":"K Ban","year":"2010","unstructured":"Ban K, Mori M, Tsunoda H, et al. A case of adenoma of the nipple detected by resident screening. J Jpn Assoc Breast Cancer Screen. 2010;19(1):67\u201370.","journal-title":"J Jpn Assoc Breast Cancer Screen"},{"issue":"6","key":"1869_CR18","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.5795\/jjscc.33.1098","volume":"33","author":"T Nshikata","year":"1994","unstructured":"Nshikata T, Sasou S, Saitou T, et al. A case of adenoma of the nipple; cytopathologic features. J Jpn Soc Clin Cytol. 1994;33(6):1098\u2013101.","journal-title":"J Jpn Soc Clin Cytol"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01869-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-01869-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01869-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T08:06:23Z","timestamp":1711353983000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-01869-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1869"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-01869-y","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"25 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of this case report and the accompanying images was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"70"}}