{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:54:33Z","timestamp":1740174873289,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The age of onset of the phyllodes tumor is generally in the late 40\u00a0s, and diagnosis and treatment during pregnancy and lactation are rare. We herein present a case of a phyllodes tumor that rapidly increased in size during the pregnancy and lactation period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 39-year-old woman was referred to our hospital with a mass in the right breast that increased in size during the pregnancy and lactation period. On ultrasound (5\u00a0week postpartum), a well-defined lobulated mass with internal septations and fluid retention was observed. Magnetic resonance imaging of the breast at 8 week postpartum revealed a 70-mm-sized smooth-margin mass with multilocular cystic components. Marked proliferation of stromal cells with high cell density was observed in a biopsy specimen taken at the previous hospital. We diagnosed the mass as a phyllodes tumor of borderline malignancy and excised it at 13\u00a0week postpartum. The excised tumor was 85\u00a0mm in diameter and its interior was filled with a milk-like substance. Histologically, there was only a mild increase in stromal cell density but fibrosis with associated degeneration was prominent. The final diagnosis was benign phyllodes tumor with degeneration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We report a case of a phyllodes tumor that rapidly increased in size during pregnancy and the lactation period. The accumulation of a milk-like substance was thought to be responsible for the rapid growth of the tumor.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01895-w","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:01:56Z","timestamp":1713931316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of phyllodes tumor with rapid growth during pregnancy and lactation period: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"Shiori","family":"Tohyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-0768","authenticated-orcid":false,"given":"Yoshiya","family":"Horimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Ushiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Semba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiori","family":"Hotchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Sugano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"1895_CR1","volume-title":"WHO classification of tumours","author":"B Tumours","year":"2019","unstructured":"Tumours B. 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Fatal outcome of malignant phyllodes tumor of the breast in pregnancy: a case and literature review. Gland Surg. 2021;10:371\u20137.","journal-title":"Gland Surg"},{"key":"1895_CR5","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.radcr.2023.11.019","volume":"19","author":"TT Faulds","year":"2024","unstructured":"Faulds TT, Bruckner J, Mousa M, Bhanu S, Chin M, Cendrowski K. Giant phyllodes tumor of the breast: a case report. Radiol Case Rep. 2024;19:818\u201324.","journal-title":"Radiol Case Rep"},{"key":"1895_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-247340","volume":"15","author":"LY Ooi","year":"2022","unstructured":"Ooi LY, Lim GH, Gudi MA. Effect of pregnancy and lactation on a benign phyllodes tumour. BMJ Case Rep. 2022;15: e247340.","journal-title":"BMJ Case Rep"},{"key":"1895_CR7","first-page":"339","volume":"4","author":"T Likhitmaskul","year":"2015","unstructured":"Likhitmaskul T, Asanprakit W, Charoenthammaraksa S, Lohsiriwat V, Supaporn S, Vassanasiri W, Sattaporn S. Giant benign phyllodes tumor with lactating changes in pregnancy: a case report. Gland Surg. 2015;4:339\u201343.","journal-title":"Gland Surg"},{"key":"1895_CR8","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/j.1525-1438.2007.01077.x","volume":"18","author":"D Nejc","year":"2008","unstructured":"Nejc D, Pasz-Walczak G, Piekarski J, Pluta P, Bilski A, Sek P, Potemski P, Durczynski A, Wronski K, Jeziorski A. Astonishingly rapid growth of malignant cystosarcoma phyllodes tumor in a pregnant woman: a case report. Int J Gynecol Cancer. 2008;18:856\u20139.","journal-title":"Int J Gynecol Cancer"},{"key":"1895_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5468\/ogs.2013.56.3.143","volume":"56","author":"JH Yu","year":"2013","unstructured":"Yu JH, Kim MJ, Cho H, Liu HJ, Han SJ, Ahn TG. Breast diseases during pregnancy and lactation. Obstet Gynecol Sci. 2013;56:143\u201359.","journal-title":"Obstet Gynecol Sci"},{"key":"1895_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13669-012-0037-0","volume":"2","author":"SS Lee","year":"2013","unstructured":"Lee SS, Hartman HJ, Kuzmiak CM, Crosby KL. The management of breast symptoms in the pregnant and lactating patient. 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