{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:53:46Z","timestamp":1740174826288,"version":"3.37.3"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Grants-in-Aid for Research from the National Center for Global Health and Medicine","award":["21A-1019"],"award-info":[{"award-number":["21A-1019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Colorectal cancer can invade adjacent organs, but rarely metastasizes to the regional lymph nodes (LNs) of the invaded organ. Herein, we report a case of rectal cancer invading the ileum and metastasized to the regional ileal LNs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 77-year-old male presented abdominal pain and anorexia, diagnosed with rectal cancer invading the small intestine and concurrently metastasized to the regional LN of the intestine and liver. High anterior resection and partial resection of the small intestine was performed, then, the patient was referred to our hospital for chemotherapy. We performed 17 cycles of systemic chemotherapy that achieved a partial reduction in size of the LN, followed by an ileocecal resection with ileal mesentery resection for regional LNs removal. Histopathological analysis of the resected ileal LNs and six liver lesions revealed a moderately differentiated tubular adenocarcinoma. The patient was discharged on postoperative day 18. Cancer recurrences developed in the lungs 5\u00a0months after the surgery, then to the liver and peritoneum, and further surgery and chemotherapy were performed. Despite the challenging presentation, the patient survived for 40\u00a0months after the first surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We report a rare case of a surgical resection of a secondary ileal LN metastasis from rectal cancer. The patient survives for a relatively long time after surgical resection. When colorectal cancer invades the small intestine, clinicians should consider the possibility of secondary LN metastasis in the invaded site.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01912-y","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T03:40:32Z","timestamp":1715398832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary ileal lymph node metastases from rectal cancer: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"Makoto","family":"Ando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-0689","authenticated-orcid":false,"given":"Nobuyuki","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhi","family":"Yoshizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyuki","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomichi","family":"Kiyomatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kokudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"1912_CR1","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.3862\/jcoloproctology.43.1198","volume":"43","author":"M Ueno","year":"1990","unstructured":"Ueno M, Ohta H, Azekura K, Seki M, Momono Y, Suzuki H, et al. Combined resection of adjacent organs in the treatment of colon cancer. J Jpn Soc Coloproctol. 1990;43:1198\u2013204.","journal-title":"J Jpn Soc Coloproctol."},{"key":"1912_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/00000658-200202000-00009","volume":"235","author":"T Lehnert","year":"2002","unstructured":"Lehnert T, Methner M, Pollok A, Schaible A, Hinz U, Herfarth C. Multivisceral resection for locally advanced primary colon and rectal cancer: an analysis of prognostic factors in 201 patients. Ann Surg. 2002;235:217\u201325.","journal-title":"Ann Surg"},{"key":"1912_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40792-021-01114-w","volume":"7","author":"S Eto","year":"2021","unstructured":"Eto S, Omura N, Shimada T, Takishima T, Takeuchi H, Kai W, et al. Laparoscopic resection of a metachronous secondary lymph node metastasis in the mesentery of the ileum after surgery for sigmoid colon cancer with ileum invasion: a case report. Surg Case Rep. 2021;7:31.","journal-title":"Surg Case Rep"},{"key":"1912_CR4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12957-016-1026-y","volume":"14","author":"A Takiyama","year":"2016","unstructured":"Takiyama A, Nozawa H, Ishihara S, Takiyama H, Murono K, Yasuda K, et al. Secondary metastasis in the lymph node of the bowel invaded by colon cancer: a report of three cases. World J Surg Oncol. 2016;14:273.","journal-title":"World J Surg Oncol."},{"key":"1912_CR5","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1200\/JCO.20.02447","volume":"39","author":"Y Kanemitsu","year":"2021","unstructured":"Kanemitsu Y, Shitara K, Mizusawa J, Hamaguchi T, Shica D, Komori K, et al. Primary tumor resection plus chemotherapy versus chemotherapy alone for colorectal cancer patients with asymptomatic, synchronous unresectable metastases (JCOG1007; iPACS): a randomized clinical trial. J Clin Oncol. 2021;39:1098\u2013107.","journal-title":"J Clin Oncol"},{"key":"1912_CR6","doi-asserted-by":"publisher","first-page":"544","DOI":"10.5833\/jjgs.45.544","volume":"45","author":"R Hiraga","year":"2012","unstructured":"Hiraga R, Koide N, Komatsu D, Yoshizawa A, Miyagawa S. A transverse colon cancer invading the stomach with No.3-node metastasis at the gastric angle. Jpn J Gastroenterol Surg. 2012;45:544\u201351.","journal-title":"Jpn J Gastroenterol Surg."}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01912-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-01912-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01912-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T03:41:51Z","timestamp":1715398911000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-01912-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1912"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-01912-y","relation":{},"ISSN":["2198-7793"],"issn-type":[{"type":"electronic","value":"2198-7793"}],"subject":[],"published":{"date-parts":[[2024,5,11]]},"assertion":[{"value":"28 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the ethical standards of the Japan Surgical Society.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient presented in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests associated with this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"117"}}