{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:51:59Z","timestamp":1762509119678,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The safety of laparoscopic hepatectomy for inherited coagulation disorders is unclear; however, the safety of open hepatectomy has been reported in several studies. Herein, we report the first case of a laparoscopic hepatectomy for a patient with von Willebrand Disease (VWD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 76-year-old male with a history of chronic hepatitis C and VWD type 2B was advised surgical resection of a 4\u00a0cm hepatocellular carcinoma in segment 7 of the liver. The patient was diagnosed with VWD in his 40\u00a0s due to gastrointestinal bleeding caused by gastric erosion. The von Willebrand factor (VWF) ristocetin cofactor activity was 30%, and VWF large multimer deficiency and increased ristocetin-induced platelet agglutination were observed. The preoperative platelet count was reduced to 3.5\u2009\u00d7\u200910<jats:sup>4<\/jats:sup>\/\u03bcL; however, preoperative imaging findings had no evidence of liver cirrhosis, such as any collateral formations and splenomegaly. The indocyanine green retention rate at 15\u00a0min was 10%, and his Child\u2013Pugh score was 5 (classification A). Perioperatively, VWF\/factor VIII was administered in accordance with our institutional protocol. A laparoscopic partial hepatectomy of the right posterior segment was performed. The most bleeding during surgery occurred during the mobilization of the right lobe of the liver due to inflammatory adhesion between the retroperitoneum and the tumor. Bleeding during parenchymal transection was controlable. The duration of hepatic inflow occlusion was 65\u00a0min. The surgical duration was 349\u00a0min, and the estimated blood loss was 2150\u00a0ml. Four units of red blood cells and fresh frozen plasma were transfused at the initiation of parenchymal transection, and 10 units of platelets were transfused at the end of the parenchymal transection. On postoperative day 1, the transection surface drainage fluid became hemorrhagic, and emergency contrast-enhanced computed tomography showed extravasation in the greater omentum. Percutaneous transcatheter arterial embolization of the omental branch of the right gastroepiploic artery was performed. No further postoperative interventions were required. The patient was discharged on postoperative day 14.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The indications for laparoscopic hepatectomy in patients with VWD should be carefully considered, and an open approach may still be the standard approach for patients with VWD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01960-4","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T03:40:46Z","timestamp":1719459646000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Laparoscopic liver resection for a patient of hepatocellular carcinoma with von Willebrand disease: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"O\u011fuzhan","family":"\u015eal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-0011","authenticated-orcid":false,"given":"Katsunori","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Honjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Funamizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutsugu","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"issue":"3","key":"1960_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/jhbp.1222","volume":"30","author":"T Nomi","year":"2023","unstructured":"Nomi T, Kaibori M, Tanaka S, Hirokawa F, Hokuto D, Noda T, et al. Short- and long-term outcomes of laparoscopic versus open repeat liver resection for hepatocellular carcinoma: a multicenter study. J Hepatobiliary Pancreat Sci. 2023;30(3):283\u201392. https:\/\/doi.org\/10.1002\/jhbp.1222.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"4","key":"1960_CR2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/hae.14810","volume":"29","author":"JS Stonebraker","year":"2023","unstructured":"Stonebraker JS, Iorio A, Lavin M, Rezende SM, Srivastava A, Pierce GF, et al. Reported prevalence of von Willebrand disease worldwide in relation to income classification. Haemophilia. 2023;29(4):975\u201386. https:\/\/doi.org\/10.1111\/hae.14810.","journal-title":"Haemophilia"},{"key":"1960_CR3","unstructured":"Goodeve A, James P. von Willebrand Disease. In: Adam MP, Feldman J, Mirzaa GM, et al., eds. GeneReviews(\u00ae). Seattle (WA): University of Washington, Seattle. Copyright \u00a9 1993\u20132023, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.; 1993."},{"issue":"2","key":"1960_CR4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","volume":"14","author":"WL Nichols","year":"2008","unstructured":"Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, et al. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia. 2008;14(2):171\u2013232. https:\/\/doi.org\/10.1111\/j.1365-2516.2007.01643.x.","journal-title":"Haemophilia"},{"issue":"2","key":"1960_CR5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jhep.2017.03.011","volume":"67","author":"P Bertuccio","year":"2017","unstructured":"Bertuccio P, Turati F, Carioli G, Rodriguez T, La Vecchia C, Malvezzi M, et al. Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol. 2017;67(2):302\u20139. https:\/\/doi.org\/10.1016\/j.jhep.2017.03.011.","journal-title":"J Hepatol"},{"key":"1960_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/hep.29086","volume":"67","author":"JK Heimbach","year":"2018","unstructured":"Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358\u201380.","journal-title":"Hepatology"},{"issue":"3","key":"1960_CR7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/hae.13759","volume":"25","author":"K Kobayashi","year":"2019","unstructured":"Kobayashi K, Kokudo T, Yamaguchi T, Shirata C, Uldry E, Akamatsu N, et al. Hepatectomy in patients with inherited blood coagulation disorders can be safely performed with adequate coagulation factor replacement. 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J Hepatobiliary Pancreat Sci. 2022;29(3):385\u201393. https:\/\/doi.org\/10.1002\/jhbp.1073.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"4","key":"1960_CR10","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/j.1572-0241.2003.07342.x","volume":"98","author":"U Denzer","year":"2003","unstructured":"Denzer U, Helmreich-Becker I, Galle PR, Lohse AW. Liver assessment and biopsy in patients with marked coagulopathy: value of mini-laparoscopy and control of bleeding. Am J Gastroenterol. 2003;98(4):893\u2013900.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"1960_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0039-3402425","volume":"46","author":"PK Mensah","year":"2020","unstructured":"Mensah PK, Pavord S. Managing preoperative hemostasis in patients with inherited and acquired bleeding disorders. Semin Thromb Hemost. 2020;46(1):17\u201325.","journal-title":"Semin Thromb Hemost"},{"key":"1960_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ijscr.2018.02.033","volume":"44","author":"K Sato","year":"2018","unstructured":"Sato K, Kuroda S, Kobayashi T, Shimizu S, Ohira M, Tahara H, et al. A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease. Int J Surg Case Rep. 2018;44:131\u20134. https:\/\/doi.org\/10.1016\/j.ijscr.2018.02.033.","journal-title":"Int J Surg Case Rep."},{"issue":"2","key":"1960_CR13","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1111\/hae.12378","volume":"20","author":"T Kokudo","year":"2014","unstructured":"Kokudo T, Uldry E, Degrauwe S, Demartines N, Halkic N. A successful case of right hepatectomy in a patient with von Willebrand disease. Haemophilia. 2014;20(2):e191\u20132. https:\/\/doi.org\/10.1111\/hae.12378.","journal-title":"Haemophilia"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01960-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-01960-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01960-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T03:44:25Z","timestamp":1719459865000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-01960-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1960"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-01960-4","relation":{},"ISSN":["2198-7793"],"issn-type":[{"type":"electronic","value":"2198-7793"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"6 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Institutional Review Board approval was not required for the preparation of this report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was achieved from the patient and his parents for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interests to declare<b>.<\/b>","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"162"}}