{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:53:50Z","timestamp":1740174830366,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Automatic stapling devices are commonly utilized in pulmonary resections, including sublobar segmentectomy. Large tumors can develop around the staple line, posing challenges in distinguishing them from cancer recurrence or inflammatory changes. In this report, we present two cases of symptomatic staple granulomatous lesion effectively managed with medications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 74-year-old man presented with a persistent cough and sputum production six years post-segmentectomy for a hamartoma in the left upper lobe. Chest computed tomography (CT) revealed a large tumor around the staple line. Laboratory investigations and bronchoscopic examination revealed no malignancy. The patient received corticosteroids and a cyclooxygenase-2 inhibitor; despite experiencing adverse reactions to steroids, both tumor size and respiratory symptoms were significantly reduced. The second case involved a 78-year-old woman who underwent pulmonary resection for suspected lung cancer. Despite a non-malignant tumor diagnosis, she reported a cough six months post-surgery. Chest CT revealed extensive shadow around the surgical staple, which was diagnosed as mycobacterium granuloma. Low-dose erythromycin induced inflammatory changes but effectively reduced the lesion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Granulomatous lesions around the staple can be effectively managed with medication, and monitoring the treatment response proves valuable in distinguishing them from tumor recurrence post-pulmonary resection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01969-9","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T12:18:28Z","timestamp":1724329108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medical management of post-sublobar resection pulmonary granulomatous lesion: a report of two cases"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-0405","authenticated-orcid":false,"given":"Hideki","family":"Endoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"Oura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutoshi","family":"Morozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitoshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"1969_CR1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ejcts.2006.11.056","volume":"31","author":"M Y\u00fcksel","year":"2007","unstructured":"Y\u00fcksel M, Akg\u00fcl AG, Evman S, Bat\u0131rel HF. Suture and stapler granulomas: a word of caution. Eur J Cardiothorac Surg. 2007;31:563\u20135. https:\/\/doi.org\/10.1016\/j.ejcts.2006.11.056.","journal-title":"Eur J Cardiothorac Surg"},{"key":"1969_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100992","volume":"14","author":"K Usuda","year":"2021","unstructured":"Usuda K, Iwai S, Yamagata A, Iijima Y, Motono N, Matoba M, et al. Differentiation between suture recurrence and suture granuloma after pulmonary resection for lung cancer by diffusion-weighted magnetic resonance imaging or FDG-PET\/CT. Transl Oncol. 2021;14: 100992. https:\/\/doi.org\/10.1016\/j.tranon.2020.100992.","journal-title":"Transl Oncol"},{"key":"1969_CR3","doi-asserted-by":"publisher","first-page":"604","DOI":"10.9738\/INTSURG-D-14-00140.1","volume":"100","author":"N Takeshita","year":"2015","unstructured":"Takeshita N, Tohma T, Miyauchi H, Suzuki K, Nishimori T, Ohira G, et al. Suture granuloma with false-positive findings on FDG-PET\/CT resected via laparoscopic surgery. Int Surg. 2015;100:604\u20137. https:\/\/doi.org\/10.9738\/INTSURG-D-14-00140.1.","journal-title":"Int Surg"},{"key":"1969_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/472642","volume":"2013","author":"K Takahara","year":"2013","unstructured":"Takahara K, Kakinoki H, Ikoma S, Udo K, Tobu S, Satoh Y, et al. Suture granuloma showing false-positive findings on FDG-PET. Case Rep Urol. 2013;2013:1\u20133. https:\/\/doi.org\/10.1155\/2013\/472642.","journal-title":"Case Rep Urol"},{"key":"1969_CR5","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","volume":"399","author":"H Saji","year":"2022","unstructured":"Saji H, Okada M, Tsuboi M, Nakajima R, Suzuki K, Aokage K, et al. Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802\/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial. Lancet. 2022;399:1607\u201317. https:\/\/doi.org\/10.1016\/S0140-6736(21)02333-3.","journal-title":"Lancet"},{"key":"1969_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0003-4975(97)01194-6","volume":"65","author":"JT Grismer","year":"1998","unstructured":"Grismer JT, Schaefer RF, Read RC. Postsegmentectomy pseudotumor of the lung. Ann Thorac Surg. 1998;65:243\u20135. https:\/\/doi.org\/10.1016\/S0003-4975(97)01194-6.","journal-title":"Ann Thorac Surg"},{"key":"1969_CR7","first-page":"123","volume":"9","author":"M Tomita","year":"2003","unstructured":"Tomita M, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Onitsuka T. Pulmonary granuloma possibly caused by staples after video-assisted thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2003;9:123\u20135.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"1969_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/thx.48.4.405","volume":"48","author":"G Fink","year":"1993","unstructured":"Fink G, Herskovitz P, Nili M, Hadar H, Rothem A, Spitzer SA. Suture granuloma simulating lung neoplasm occurring after segmentectomy. Thorax. 1993;48:405\u20136. https:\/\/doi.org\/10.1136\/thx.48.4.405.","journal-title":"Thorax"},{"key":"1969_CR9","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.juro.2007.10.054","volume":"179","author":"S Hinz","year":"2008","unstructured":"Hinz S, Schrader M, Kempkensteffen C, Bares R, Brenner W, Krege S, et al. The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma. J Urol. 2008;179:936\u201340. https:\/\/doi.org\/10.1016\/j.juro.2007.10.054.","journal-title":"J Urol"},{"key":"1969_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13019-020-1055-z","volume":"15","author":"M Okazaki","year":"2020","unstructured":"Okazaki M, Sano Y, Mori Y, Sakao N, Yukumi S, Shigematsu H, et al. Two cases of granuloma mimicking local recurrence after pulmonary segmentectomy. J Cardiothorac Surg. 2020;15:7. https:\/\/doi.org\/10.1186\/s13019-020-1055-z.","journal-title":"J Cardiothorac Surg"},{"key":"1969_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.21037\/jtd-21-1626","volume":"14","author":"N Matsuura","year":"2022","unstructured":"Matsuura N, Igai H, Ohsawa F, Yazawa T, Kamiyoshihara M. Differentiation between staple line granuloma and recurrence after sublobar resection for primary lung cancer. J Thorac Dis. 2022;14:26\u201335. https:\/\/doi.org\/10.21037\/jtd-21-1626.","journal-title":"J Thorac Dis"},{"key":"1969_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s12055-019-00824-z","volume":"35","author":"K Matsuoka","year":"2019","unstructured":"Matsuoka K, Yamada T, Matsuoka T, Nagai S, Ueda M, Miyamoto Y. Nodule around the staple line after pulmonary resection: benign granuloma or cancer recurrence? Indian J Thorac Cardiovasc Surg. 2019;35:569\u201374. https:\/\/doi.org\/10.1007\/s12055-019-00824-z.","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"1969_CR13","doi-asserted-by":"publisher","first-page":"790","DOI":"10.2482\/haigan.54.790","volume":"54","author":"M Yoshino","year":"2014","unstructured":"Yoshino M, Sekine Y, Koh E, Hata A, Katsura H, Hiroshima K. Pulmonary granuloma associated with non-tuberculous mycobacteriosis occurring at the staple line after segmentectomy for lung cancer: report of a case. Jpn J Lung Cancer. 2014;54:790\u20134. https:\/\/doi.org\/10.2482\/haigan.54.790.","journal-title":"Jpn J Lung Cancer"},{"key":"1969_CR14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.rmcr.2014.02.002","volume":"12","author":"S Takeda","year":"2014","unstructured":"Takeda S, Akagi T, Miyazaki H, Kodama M, Yamamoto S, Beppu T, et al. Two patients with new granulomatous lung lesions during treatment of Crohn\u2019s disease. Respir Med Case Rep. 2014;12:16\u20138. https:\/\/doi.org\/10.1016\/j.rmcr.2014.02.002.","journal-title":"Respir Med Case Rep"},{"key":"1969_CR15","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3892\/ol.2013.1260","volume":"5","author":"C Chavez","year":"2013","unstructured":"Chavez C, Hoffman MA. Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: a case report and review of the literature. Oncol Lett. 2013;5:1672\u20136. https:\/\/doi.org\/10.3892\/ol.2013.1260.","journal-title":"Oncol Lett"},{"key":"1969_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/bioengineering10010117","volume":"10","author":"R Nickl","year":"2023","unstructured":"Nickl R, Hauser S, Pietzsch J, Richer T. Significance of pulmonary endothelial injury and the role of cyclooxygenase-2 and prostanoid signaling. Bioengineering. 2023;10:117. https:\/\/doi.org\/10.3390\/bioengineering10010117.","journal-title":"Bioengineering"},{"key":"1969_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2478\/rjim-2021-0016","volume":"59","author":"K Nishino","year":"2021","unstructured":"Nishino K, Iguchi K, Ishibashi O, Sasatani Y, Ohara G, Kagohashi K, et al. Imaging characteristics of nontuberculous mycobacterial pulmonary nodules. Rom J Intern Med. 2021;59:369\u201374. https:\/\/doi.org\/10.2478\/rjim-2021-0016.","journal-title":"Rom J Intern Med"},{"key":"1969_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ijantimicag.2014.03.017","volume":"44","author":"K Komiya","year":"2014","unstructured":"Komiya K, Kurashima A, Ihi T, Nagai H, Matsumoto N, Mizunoe S, et al. Long-term, low-dose erythromycin monotherapy for Mycobacterium avium complex lung disease: a propensity score analysis. Int J Antimicrob Agents. 2014;44:131\u20135. https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.03.017.","journal-title":"Int J Antimicrob Agents"},{"key":"1969_CR19","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jiac.2017.12.008","volume":"24","author":"Y Hosono","year":"2018","unstructured":"Hosono Y, Kitada S, Yano Y, Mori M, Miki K, Miki M, et al. The association between erythromycin monotherapy for mycobacterium avium complex lung disease and cross-resistance to clarithromycin: a retrospective case-series study. J Infect Chemother. 2018;24:353\u20137. https:\/\/doi.org\/10.1016\/j.jiac.2017.12.008.","journal-title":"J Infect Chemother"},{"key":"1969_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2478\/cipms-2014-0015","volume":"27","author":"M Bulska","year":"2014","unstructured":"Bulska M, Orszulak-Michalak D. Immunomodulatory and anti-inflammatory properties of macrolides. Curr Issues Pharm Med Sci. 2014;27:61\u20134. https:\/\/doi.org\/10.2478\/cipms-2014-0015.","journal-title":"Curr Issues Pharm Med Sci"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01969-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-01969-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01969-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:29:34Z","timestamp":1724434174000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-01969-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1969"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-01969-9","relation":{},"ISSN":["2198-7793"],"issn-type":[{"type":"electronic","value":"2198-7793"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"14 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was approved by the Institutional Ethics Review Board (reference no. 015\u2013001\u2013220601, 03 October 2022, Saku Central Hospital Advanced Care Center).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from both patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}