{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:53:50Z","timestamp":1740174830385,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ehlers\u2013Danlos syndrome (EDS) is a rare inherited connective tissue disease characterized by hyperextensibility of the skin and joints and tissue fragility of the skin and blood vessels, Vascular EDS is the most severe form of EDS, with abnormal arterial fragility. There have been no reports of breast cancer occurring in patients with vascular EDS. Here, we report here a very rare case of breast cancer in a patient with vascular EDS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 46-year-old woman with vascular EDS underwent partial left mastectomy and sentinel lymph node biopsy for left breast cancer (cStage 0) detected by medical examination. The final pathological diagnosis was invasive ductal carcinoma of the breast (pStage IA) [hormone receptor-positive, HER2 score 2 equivocal (FISH-positive), Ki-67LI 18%, luminal-HER2 type]. BluePrint was submitted as an aid in determining the postoperative treatment strategy, BluePrint Molecular Subtype HER2-type. However, the 10-year breast cancer mortality risk using Predict was low (5%). After consultation with the patient, the decision was made to administer postoperative radiation to the preserved breast along with hormone therapy only. There was no delay in postoperative wound healing, and the patient was free of metastatic recurrence for 9 months after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We performed surgery, postoperative radiotherapy, and hormonal therapy in a breast cancer patient with vascular EDS without major complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-01997-5","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:15:53Z","timestamp":1724451353000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical and irradiated case of early breast cancer in a patient with Ehlers\u2013Danlos syndrome"],"prefix":"10.1186","volume":"10","author":[{"given":"Asumi","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-8982","authenticated-orcid":false,"given":"Hiroshi","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Muroyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narumi","family":"Harada-Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Hamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ebata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miku","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokiwa","family":"Motonari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Yanagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Kon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aru","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"issue":"1","key":"1997_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O","volume":"77","author":"P Beighton","year":"1998","unstructured":"Beighton P, de Paepe A, et al. Ehlers-Danlos syndromes: revised nosology, villefranche, 1997. Ehlers-Danlos national foundation (USA) and Ehlers-Danlos support group (UK). Am J Med Genet. 1998;77(1):31\u20137.","journal-title":"Am J Med Genet"},{"key":"1997_CR2","doi-asserted-by":"publisher","first-page":"1053466","DOI":"10.3389\/fmed.2023.1053466","volume":"10","author":"BJ Doolan","year":"2023","unstructured":"Doolan BJ, Lavallee ME, Hausser I, Schubart JR, Michael Pope F, Seneviratne SL, et al. Extracutaneous features and complications of the Ehlers-Danlos syndrome: a systematic review. Front Med. 2023;10:1053466. https:\/\/doi.org\/10.3389\/fmed.2023.1053466.","journal-title":"Front Med"},{"key":"1997_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ajmg.c.31552","volume":"175","author":"F Malfait","year":"2017","unstructured":"Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C. 2017;175:8\u201326. https:\/\/doi.org\/10.1002\/ajmg.c.31552.","journal-title":"Am J Med Genet C"},{"key":"1997_CR4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1056\/NEJM200003093421001","volume":"342","author":"M Pepin","year":"2000","unstructured":"Pepin M, Schwarze U, Superti-Furga A, Byears PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, vascular type IV. N Engl J Med. 2000;342:673\u201380. https:\/\/doi.org\/10.1056\/NEJM200003093421001.","journal-title":"N Engl J Med"},{"key":"1997_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/ajmg.c.31553","volume":"175","author":"PH Byers","year":"2017","unstructured":"Byers PH, Belmont J, Black J, De Backer J, Frank M, Jeunemaitre X, et al. Diagnosis, natural history, and management of vascular Ehlers-Danlos syndrome. Am J Med Genet C. 2017;175:40\u20137. https:\/\/doi.org\/10.1002\/ajmg.c.31553.","journal-title":"Am J Med Genet C"},{"key":"1997_CR6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1001\/archsurg.1974.01360040001001","volume":"109","author":"VA McKusick","year":"1974","unstructured":"McKusick VA. Multiple forms of Ehlers-Danlos syndrome. Arch Surg. 1974;109:475\u20136. https:\/\/doi.org\/10.1001\/archsurg.1974.01360040001001.","journal-title":"Arch Surg"},{"issue":"4","key":"1997_CR7","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s12282-024-01589-z","volume":"31","author":"Y Yamamoto","year":"2024","unstructured":"Yamamoto Y, Chikako Y, Tatsuya T, Shigenori N, Takehiko S, Goro K, Michio Y, et al. Correction: the Japanese breast cancer society clinical practice guidelines for breast cancer, 2022 edition: changes from the 2018 edition and general statements on breast cancer treatment. Breast Cancer. 2024;31(4):736\u20137.","journal-title":"Breast Cancer"},{"key":"1997_CR8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50346","volume":"15","author":"MT Hsieh","year":"2023","unstructured":"Hsieh MT, Amalaseelan J, Mohd Rahir AR, Le T, Shakespeare TP. No increase in acute or late radiation toxicities in patients with Ehlers-Danlos syndrome receiving adjuvant breast radiation therapy: a report of four cases with extended follow-up. Cureus. 2023;15: e50346. https:\/\/doi.org\/10.7759\/cureus.50346.","journal-title":"Cureus"},{"key":"1997_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/tbj.12878","volume":"24","author":"T Chau","year":"2018","unstructured":"Chau T, Chen AY. Successful case of breast conservation radiotherapy in a patient with type III Ehlers-Danlos syndrome. Breast J. 2018;24:221\u20132. https:\/\/doi.org\/10.1111\/tbj.12878.","journal-title":"Breast J"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01997-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-01997-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-01997-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:21:41Z","timestamp":1724451701000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-01997-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1997"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-01997-5","relation":{},"ISSN":["2198-7793"],"issn-type":[{"type":"electronic","value":"2198-7793"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"1 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the Ethics Committee of Tohoku University Hospital (No. 35963).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and the accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"195"}}