{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:36:14Z","timestamp":1780317374734,"version":"3.54.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Capicua transcriptional repressor-double homeobox 4 sarcoma (CDS) is a rare and aggressive malignant soft tissue tumor that typically arises within the soft tissues. We report an exceptionally rare case of a gastric CDS successfully resected despite its extensive invasion into surrounding organs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 48-year-old male presented with a progressively enlarging abdominal mass. Upper gastrointestinal endoscopy revealed a large ulcerative tumor on the posterior gastric wall. Biopsy results initially suggested a neuroendocrine cell carcinoma. Contrast-enhanced computed tomography showed a 20\u00a0cm tumor protruding from the posterior stomach wall, directly invading the pancreas and colon. We performed a multivisceral resection (stomach, pancreatic tail, spleen, and transverse colon) achieving an R0 resection. Pathological examination of the permanent specimen revealed small round cells with high nuclear-to-cytoplasmic ratios. Immunohistochemical staining confirmed the diagnosis of CDS. The patient recovered well and was discharged on postoperative day 33.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case report describes the first detailed account of a surgically resected aggressive CDS originating from the stomach.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40792-024-02035-0","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:03:38Z","timestamp":1729674218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An aggressive gastric CIC-DUX4 sarcoma surgically resected with multivisceral organs: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"Mizuki","family":"Koba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-2942","authenticated-orcid":false,"given":"Atsushi","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Sakamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Higashiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reishi","family":"Toshiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihito","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Hirao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"2035_CR1","volume-title":"Soft tissue and bone tumors WHO classification of tumors","author":"World Health Organization","year":"2020","unstructured":"World Health Organization. Soft tissue and bone tumors WHO classification of tumors. 5th ed. Lyon: WHO; 2020.","edition":"5"},{"issue":"7","key":"2035_CR2","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/PAS.0000000000000846","volume":"41","author":"CR Antonescu","year":"2017","unstructured":"Antonescu CR, Owosho AA, Zhang L, Chen S, Deniz K, Huryn JM, et al. Sarcomas with CIC-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases. Am J Surg Pathol. 2017;41(7):941\u20139. https:\/\/doi.org\/10.1097\/PAS.0000000000000846.","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"2035_CR3","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1002\/cam4.4580","volume":"11","author":"EA Connolly","year":"2022","unstructured":"Connolly EA, Bhadri VA, Wake J, Ingley KM, Lewin J, Bae S, et al. Systemic treatments and outcomes in CIC-rearranged sarcoma: a national multi-centre clinicopathological series and literature review. Cancer Med. 2022;11(8):1805\u201316. https:\/\/doi.org\/10.1002\/cam4.4580.","journal-title":"Cancer Med"},{"issue":"2","key":"2035_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae.","journal-title":"Ann Surg"},{"issue":"3","key":"2035_CR5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/PAS.0000000000000570","volume":"40","author":"A Yoshida","year":"2016","unstructured":"Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, et al. CIC-rearranged sarcomas: a study of 20 cases and comparisons with Ewing sarcomas. Am J Surg Pathol. 2016;40(3):313\u201323. https:\/\/doi.org\/10.1097\/PAS.0000000000000570.","journal-title":"Am J Surg Pathol"},{"key":"2035_CR6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/gcc.22172","volume":"53","author":"K Specht","year":"2014","unstructured":"Specht K, Sung YS, Zhang L, Richter G, Fletcher CD, Antonescu CR. Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion\u2013positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: further evidence toward distinct pathologic entities. Genes Chromosomes Cancer. 2014;53:622\u201333. https:\/\/doi.org\/10.1002\/gcc.22172.","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"2035_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/PAS.0000000000000772","volume":"41","author":"B Siegele","year":"2017","unstructured":"Siegele B, Roberts J, Black JO, Rudzinski E, Vargas SO, Galambos C. DUX4 immunohistochemistry is a highly sensitive and specific marker for CIC-DUX4 fusion-positive round cell tumor. Am J Surg Pathol. 2017;41(3):423\u20139. https:\/\/doi.org\/10.1097\/PAS.0000000000000772.","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"2035_CR8","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/modpathol.2016.155","volume":"29","author":"S Le Guellec","year":"2016","unstructured":"Le Guellec S, Velasco V, P\u00e9rot G, Watson S, Tirode F, Coindre JM. ETV4 is a useful marker for the diagnosis of CIC-rearranged undifferentiated round-cell sarcomas: a study of 127 cases including mimicking lesions. Mod Pathol. 2016;29(12):1523\u201331. https:\/\/doi.org\/10.1038\/modpathol.2016.155.","journal-title":"Mod Pathol"},{"issue":"10","key":"2035_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fonc.2020.00489","volume":"15","author":"D Racanelli","year":"2020","unstructured":"Racanelli D, Brenca M, Baldazzi D, Goeman F, Casini B, De Angelis B, et al. Next-generation sequencing approaches for the identification of pathognomonic fusion transcripts in sarcomas: the experience of the Italian ACC sarcoma working group. Front Oncol. 2020;15(10):489. https:\/\/doi.org\/10.3389\/fonc.2020.00489.","journal-title":"Front Oncol"},{"issue":"12","key":"2035_CR10","doi-asserted-by":"publisher","first-page":"1018992","DOI":"10.3389\/fonc.2022.1018992","volume":"15","author":"Q Wu","year":"2022","unstructured":"Wu Q, He Y. A case report of CIC-DUX4 fusion-positive sarcoma in the pelvic cavity with targeted next-generation sequencing results. 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Cancers. 2022;14(21):5411. https:\/\/doi.org\/10.3390\/cancers14215411.","journal-title":"Cancers"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-02035-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-024-02035-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-024-02035-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:06:54Z","timestamp":1729674414000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-024-02035-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2035"],"URL":"https:\/\/doi.org\/10.1186\/s40792-024-02035-0","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"25 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was approved by a constituted ethics committee of our hospital, and it conforms to the provisions of the 1995 Declaration of Helsinki (as revised in Brazil 2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and the accompanying images. A copy of the written consent form is available for review by the editor-in-chief of the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"241"}}