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Their gas fluxes, which include CO\n                      <jats:sub>2<\/jats:sub>\n                      , CO, H\n                      <jats:sub>2<\/jats:sub>\n                      S and SO\n                      <jats:sub>2<\/jats:sub>\n                      , mirror the chemical composition of CO\n                      <jats:sub>2<\/jats:sub>\n                      -rich waste streams. Microbial communities inhabiting these environments are typically thermotolerant or thermophilic and sustained by CO\n                      <jats:sub>2<\/jats:sub>\n                      fixation and chemolithotrophic metabolism. Such communities may therefore provide a natural starting point for developing\n                      <jats:italic>ex-situ<\/jats:italic>\n                      , consortium-based biotechnologies capable of operating under elevated temperatures and chemically harsh conditions. Here, we assess the metabolic capabilities of hot spring microbiomes systematically through a biotechnological lens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We conducted comparative analysis of 73 worldwide hot spring metagenomes, spanning a wide range of environmental conditions (pH 1.5\u201310.0, temperatures 25\u201398\u00a0\u00b0C). By taking a gene-centric approach to whole communities, we show that hot spring microbiomes ubiquitously encoded carbon fixation pathways and biosynthetic genes (and gene clusters) for the synthesis of value-added products, regardless of geographical location and pH-temperature conditions. Candidate value-added products include platform chemicals such as acetone, lactic acid, and 1,2-propanediol, as well as high-value biomolecules including B vitamins and alginate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This first biotechnology-focused assessment of hot spring microbiomes demonstrates that these communities encode the genomic potential to support novel,\n                      <jats:italic>ex situ<\/jats:italic>\n                      microbial platforms for upgrading CO\n                      <jats:sub>2<\/jats:sub>\n                      and transforming chemically complex gas mixtures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      Industrial CO\n                      <jats:sub>2<\/jats:sub>\n                      waste streams pose both an environmental challenge and an unutilised resource. Harnessing microbial consortia to valorise CO\n                      <jats:sub>2<\/jats:sub>\n                      , through a circular bioeconomy, remains underexplored and could offer an alternative to energy-intensive chemical methods. By reanalysing predominantly publicly available metagenomic data, we demonstrate how hot spring microbiomes can be mined for traits pre-adapted to CO\n                      <jats:sub>2<\/jats:sub>\n                      -rich, high-temperature, and chemically extreme conditions. In doing so, we provide proof-of-concept for their future biotechnological application and establish a blueprint for other microbiome-scale bioprospecting surveys.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40793-026-00875-x","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:56:34Z","timestamp":1773240994000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the biotechnological potential of terrestrial hot spring microbiomes for CO2 utilisation"],"prefix":"10.1186","volume":"21","author":[{"given":"Christopher E.","family":"Stead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"R Cousins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Breitling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snaed\u00eds Huld","family":"Bj\u00f6rnsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"13","key":"875_CR1","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1128\/AEM.02751-08","volume":"75","author":"ES Boyd","year":"2009","unstructured":"Boyd ES, Leavitt WD, Geesey GG. 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