{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:05:03Z","timestamp":1788267903462,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Factors Group Australia Pty Ltd"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nutr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Safe and effective weight control strategies are needed to curtail the current obesity epidemic worldwide. Increasing dietary fibre has shown positive results with weight loss as well as in the reduction of metabolic syndrome risk factors. However, fibre can act as an inhibitor to the bioavailability of micronutrients in the gastrointestinal tract. While there is a substantial amount of scientific research into psyllium fibre, PolyGlycopleX (PGX\u00ae) is a novel fibre and as yet the effects of PGX\u00ae on micronutrient status is not well researched.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>To determine whether 3-months\u2019 supplementation with 15\u00a0g of psyllium or PGX\u00ae fibre daily affects micronutrient status of overweight and obese adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Overweight and obese individuals with a BMI between 25\u201340\u00a0kg\/m<jats:sup>2<\/jats:sup> and aged between 18 and 65\u00a0years, but otherwise healthy, were instructed to consume a 5\u00a0g sachet of psyllium, PGX\u00ae fibre or a rice flour placebo three times a day for 52\u00a0weeks as part of a larger long-term study. Blood sample data for the first 3\u00a0months were analysed for associations between serum micronutrient levels and psyllium fibre and\/or PGX\u00ae supplements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No significant differences between fibre supplement groups and micronutrient status were found after 3\u00a0months at <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05. Dietary intake of vitamin C was significantly lower for PGX\u00ae at 3\u00a0months compared to baseline and compared to control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Folate was significantly lower in the control group after 3\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the psyllium group, folate, sodium, zinc and magnesium intake decreased after 3\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A limitation of dietary intake data (tertiary measure) is the potential for inaccurate self-reporting, although reduced nutrient intake could be due to the satiating effect of dietary fibre.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There were no significant between group differences in serum micronutrient concentrations after a 3-month psyllium fibre or PGX\u00ae supplementation intervention of 15\u00a0g per day. Fibre supplementation is unlikely to compromise the nutritional status of overweight and obese individuals in the short term. Further research is recommended to monitor micronutrient status over a longer period or with a higher fibre dosage.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40795-022-00534-7","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T08:02:56Z","timestamp":1651564976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Micronutrient status of individuals with overweight and obesity following 3\u00a0months\u2019 supplementation with PolyGlycopleX (PGX\u00ae) or psyllium: a randomized controlled trial"],"prefix":"10.1186","volume":"8","author":[{"given":"Sebely","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Jane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland J.","family":"Gahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"issue":"Suppl 4","key":"534_CR1","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1038\/sj.ijo.0802209","volume":"26","author":"S Rossner","year":"2002","unstructured":"Rossner S. 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All components of the present study strictly adhered to the HREC guidelines. All participants provided signed, written informed consent, and were made aware that their participation was voluntary and that they could withdraw from the study at any time. Ongoing privacy, security and protection of the identity and information of participants was ensured for all future data collected as part of the present study. In addition, the larger clinical trial was registered with the Australian New Zealand Clinical Trial Registry on 20 April 2011, registration number: ACTRN12611000415909.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SW receives consulting fees from InovoBiologic Inc, Canada. S Wood has an InovoBiologic Inc. patent pending. RJG is the owner of the Factors Group of Companies and holds various patents on PGX\u00ae. All other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}