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Fatigue may stem from disruptions in circadian rhythms and dysregulation of glucose metabolism, which can be improved through time-restricted eating. Time-restricted eating is a daily eating pattern that entails consuming food within a defined, consistent window (e.g., 10\u00a0h) every day. When the eating window aligns with the daylight hours, it can entrain circadian processes and modulate physiological regulation of whole-body metabolism. It is hypothesized that time-restricted eating can relieve cancer-related fatigue in blood cancer survivors via regulating circadian rhythms and improving metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This trial is a phase II randomized controlled trial comparing the effects of time-restricted eating (10\u00a0h daytime feeding\/14\u00a0h fasting at night) vs. a time-, attention, and expectancy-matched control nutrition counseling intervention (no time component) on cancer-related fatigue. A total of 96 blood cancer survivors will be recruited; eligible survivors will be 2 months to 2 years post-adjuvant chemotherapy, report moderate to severe fatigue, consume food within a window that is &gt;\u200910\u00a0h, and not be employed in night-shift work. At baseline, 6 weeks, and 12 weeks (post-intervention), assessments include patient-reported fatigue, measures of circadian rest-activity rhythm, and glucose metabolism via continuous glucose monitoring. Participants will log their food intake using the myCircadianClock smartphone app at baseline and throughout the 12-week study. At 24 weeks (12 weeks post-intervention), questionnaires will probe maintenance of the dietary pattern and sustainability of any intervention effects on fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Time-restricted eating is scalable and free-of-cost, lending itself to accessibility for the vast majority of cancer survivors. Data generated herein will be used to inform a larger, phase III multisite clinical trial testing the effects of time-restricted eating on cancer-related fatigue among survivors of hematological malignancies, and further optimize interventions that entrain circadian rhythms and improve glucose metabolism to alleviate cancer-related fatigue and other supportive care outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>clinicaltrials.gov ID: NCT06482515.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40795-025-01185-0","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:20:05Z","timestamp":1761902405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Take the reins: a study protocol of a randomized controlled trial testing the effects of time-restricted eating vs. nutrition control on cancer-related fatigue among survivors of hematological malignancies"],"prefix":"10.1186","volume":"11","author":[{"given":"Amber S.","family":"Kleckner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin L.","family":"Clingan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf Z.","family":"Badros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily N. 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