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To control<jats:italic>T. gondii<\/jats:italic>infections in pigs, European Food Safety Agency (EFSA) advises serological testing of pigs and audits of pig farms to identify risk factors for<jats:italic>T. gondii<\/jats:italic>infection. In line with this approach, the aim of the current study was to assess the effectiveness and costs of intervention measures implemented to reduce the<jats:italic>T. gondii<\/jats:italic>seroprevalence on finishing pig farms in the Netherlands. A crossover clinical trial was conducted at five case farms were their own control and the cross-over moment was the implementation of interventions to reduce risk factors. Each of the case farms had a farm-specific intervention strategy with one principal intervention measure (neutering of cats, professional rodent control or covering food storage).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All finishing pig farms (<jats:italic>n<\/jats:italic>\u2009=\u20095) showed a reduction in<jats:italic>T. gondii<\/jats:italic>seroprevalence within one year of implementing the intervention strategy. Cat neutering (<jats:italic>n<\/jats:italic>\u2009=\u20093) and feed coverage (<jats:italic>n<\/jats:italic>\u2009=\u20091) showed statistically significant reductions in seroprevalence. Rodent control (<jats:italic>n<\/jats:italic>\u2009=\u20091) did not show a statistically significant reduction. The estimated reduction in seroprevalence in response to the neutering of cats and feed coverage were 67 and 96\u2009%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our work demonstrates that it is possible to reduce the within-farm<jats:italic>T. gondii<\/jats:italic>seroprevalence within one year after interventions were implemented to reduce<jats:italic>T. gondii<\/jats:italic>risk factors. This information is essential and encouraging for policy makers, food business operators, and farmers to implement in their risk assessment and to apply to food safety control systems.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40813-021-00223-0","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T08:02:58Z","timestamp":1627286578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness and costs of interventions to reduce the within-farm Toxoplasma gondii seroprevalence on pig farms in the Netherlands"],"prefix":"10.1186","volume":"7","author":[{"given":"Dorien M.","family":"Eppink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-8054","authenticated-orcid":false,"given":"Henk J.","family":"Wisselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge M.","family":"Krijger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke W.B.","family":"van der Giessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Swanenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen P.A.","family":"van Wagenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel A.P.M.","family":"van Asseldonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Bouwknegt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"223_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.vetpar.2009.05.018","volume":"164","author":"JP Dubey","year":"2009","unstructured":"Dubey JP. 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