{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:43:58Z","timestamp":1787021038200,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003522","name":"Crohn's and Colitis UK","doi-asserted-by":"publisher","award":["SP2016-1"],"award-info":[{"award-number":["SP2016-1"]}],"id":[{"id":"10.13039\/501100003522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pilot Feasibility Stud"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain is a poorly managed symptom of inflammatory bowel disease (IBD). Cognitive behavioural therapy (CBT) has an evidence base in functional gastrointestinal conditions and chronic pain. This study aimed to test the feasibility and acceptability of a 9-week online facilitator-supported CBT intervention, tailored for people with chronic IBD-related pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A single-arm pre-post design with nested qualitative interviews was used. Twenty individuals with IBD and chronic pain were recruited through an online IBD charity and had consented to research in a previous survey or responded to an online charity advert. Individuals who indicated a pain-interference score of \u2265 4\/10 (Brief Pain Inventory) and met inclusion criteria were invited to take part. Outcomes included recruitment and retention rates, pain interference and severity, quality of life (QoL) and psychosocial measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 145 individuals contacted, 55 (37.9%) responded. Two individuals were recruited from the study advertisement. Twenty out of 57 (35.1%) met screening and eligibility criteria. Eighty-five percent of the sample engaged with intervention sessions and 55% completed at least 5\/9 sessions. Eighty percent of recruited participants completed the post-intervention questionnaire at week 9. The mean score for overall acceptability was 43.4 (0\u201370). Qualitative feedback demonstrated the value of thought monitoring and facilitator support. Scores improved for QoL and pain self-efficacy and reduced for depression, anxiety, pain catastrophising and avoidance resting behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Online CBT for chronic IBD-related pain appears feasible and acceptable. The study suggests positive effects for improving QoL and reducing psychological distress; however, online and face-to-face recruitment methods are recommended and establishing efficacy through larger randomised controlled trials is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40814-021-00829-9","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:03:52Z","timestamp":1618531432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pain management in inflammatory bowel disease: feasibility of an online therapist-supported CBT-based self-management intervention"],"prefix":"10.1186","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-7844","authenticated-orcid":false,"given":"Louise","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona","family":"Moss-Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wladyslawa","family":"Czuber-Dochan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"829_CR1","doi-asserted-by":"crossref","unstructured":"de Jong MJ, Huibregtse R, Masclee AA, Jonkers DM, Pierik MJJCg. Patient-reported outcome measures for use in clinical trials and clinical practice in inflammatory bowel diseases: a systematic review. Clin Gastroenterol Hepatol.\u00a02018; 16(5): 648\u201363.","DOI":"10.1016\/j.cgh.2017.10.019"},{"issue":"5","key":"829_CR2","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ibd.20848","volume":"15","author":"K Bielefeldt","year":"2009","unstructured":"Bielefeldt K, Davis B, Binion DG. Pain and inflammatory bowel disease. Inflamm Bowel Dis. 2009;15(5):778\u201388.","journal-title":"Inflamm Bowel Dis"},{"key":"829_CR3","doi-asserted-by":"crossref","unstructured":"Falling C, Stebbings S, Baxter GD, Mani RJMH. Central hypersensitivity\u2013a model for persistent musculoskeletal pain in inflammatory bowel diseases.\u00a0Med Hypotheses.\u00a02019;129(109243):1\u20135.","DOI":"10.1016\/j.mehy.2019.109243"},{"issue":"6","key":"829_CR4","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/apt.14493","volume":"47","author":"L Sweeney","year":"2018","unstructured":"Sweeney L, Moss-Morris R, Czuber-Dochan W, Meade L, Chumbley G, Norton C. Systematic review: psychosocial factors associated with pain in inflammatory bowel disease. Aliment Pharmacol Ther. 2018;47(6):715\u201329.","journal-title":"Aliment Pharmacol Ther."},{"key":"829_CR5","doi-asserted-by":"crossref","unstructured":"Fretz KM, Tripp DA, Katz L, Ropeleski M, Beyak MJJJocpims. Examining psychosocial mechanisms of pain-related disability in inflammatory bowel disease. J Clin Psychol Med Settings.\u00a02019:1-8.","DOI":"10.1007\/s10880-019-09627-1"},{"issue":"2","key":"829_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/apt.14108","volume":"46","author":"C Norton","year":"2017","unstructured":"Norton C, Czuber-Dochan W, Artom M, Sweeney L, Hart A. Systematic review: interventions for abdominal pain management in inflammatory bowel disease. Aliment Pharmacol Ther. 2017;46(2):115\u201325.","journal-title":"Aliment Pharmacol Ther."},{"issue":"1","key":"829_CR7","first-page":"53","volume":"14","author":"E Szigethy","year":"2018","unstructured":"Szigethy E. Pain management in patients with inflammatory bowel disease. Gastroenterol Hepatol. 2018;14(1):53\u20136.","journal-title":"Gastroenterol Hepatol"},{"key":"829_CR8","doi-asserted-by":"crossref","unstructured":"Barlow C, Cooke D, Mulligan K, Beck E, SJGN N. A critical review of self-management and educational interventions in inflammatory bowel disease. Gastroenterol Nurs.\u00a02010;33(1):11\u20138.","DOI":"10.1097\/SGA.0b013e3181ca03cc"},{"key":"829_CR9","doi-asserted-by":"crossref","unstructured":"Chao C-Y, Lemieux C, Restellini S, Afif W, Bitton A, Lakatos PL, et al. Maladaptive coping, low self-efficacy and disease activity are associated with poorer patient-reported outcomes in inflammatory bowel disease. Saudi J Gastroenterol.\u00a02019;25(3):159\u201366.","DOI":"10.4103\/sjg.SJG_566_18"},{"key":"829_CR10","doi-asserted-by":"crossref","unstructured":"Colombel JF, Shin A, Gibson PRJCG. AGA Clinical practice update on functional gastrointestinal symptoms in patients with inflammatory bowel disease: expert review. Hepatology. 2019;17(3):380\u2013390. e1.","DOI":"10.1016\/j.cgh.2018.08.001"},{"issue":"2","key":"829_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1037\/a0035747","volume":"69","author":"DM Ehde","year":"2014","unstructured":"Ehde DM, Dillworth TM, Turner JA. Cognitive-behavioral therapy for individuals with chronic pain: Efficacy, innovations, and directions for research. Am Psychol. 2014;69(2):153\u201366.","journal-title":"Am Psychol"},{"key":"829_CR12","unstructured":"NCCMH. The Improving Access to Psychological Therapies (IAPT) Pathway for people with long-term physical health conditions and medically unexplained symptoms. Full implementation guidance. London: National Collaborating Centre for Mental Health; 2018. Available from: https:\/\/www.rcpsych.ac.uk\/docs\/default-source\/improving-care\/nccmh\/nccmh-iapt-ltc-full-implementation-guidance.pdf?sfvrsn=de824ea4_4."},{"key":"829_CR13","unstructured":"Beck JS. Cognitive behavior therapy: Basics and beyond: Guilford press; 2011."},{"key":"829_CR14","doi-asserted-by":"crossref","unstructured":"Carlbring P, Andersson G, Cuijpers P, Riper H, EJCBT H-L. Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis. Cogn Behav Ther.\u00a02018;47(1):1\u201318.","DOI":"10.1080\/16506073.2017.1401115"},{"key":"829_CR15","doi-asserted-by":"crossref","unstructured":"Cuijpers P, Donker T, van Straten A, Li J, GJPMAJoRiP A, Sciences tA. Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies. Psychol Med.\u00a02010;40(12):1943\u201357.","DOI":"10.1017\/S0033291710000772"},{"issue":"11","key":"829_CR16","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S2468-1253(19)30243-2","volume":"4","author":"HA Everitt","year":"2019","unstructured":"Everitt HA, Landau S, O\u2019Reilly G, Sibelli A, Hughes S, Windgassen S, et al. Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial. Lancet Gastroenterol Hepatol. 2019;4(11):863\u201372.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"829_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12529-016-9580-9","volume":"24","author":"A Mikocka-Walus","year":"2017","unstructured":"Mikocka-Walus A, Bampton P, Hetzel D, Hughes P, Esterman A, Andrews JM. Cognitive-Behavioural Therapy for Inflammatory Bowel Disease: 24-Month Data from a Randomised Controlled Trial. Int J Behav Med. 2017;24(1):127\u201335.","journal-title":"Int J Behav Med."},{"issue":"1","key":"829_CR18","first-page":"14","volume":"26","author":"C Jordan","year":"2019","unstructured":"Jordan C, Hayee BH, TJCp C. Cognitive behaviour therapy for distress in people with inflammatory bowel disease: a benchmarking study. Psychotherapy. 2019;26(1):14\u201323.","journal-title":"Psychotherapy"},{"key":"829_CR19","doi-asserted-by":"crossref","unstructured":"Artom M, Czuber-Dochan W, Sturt J, Norton CJT. Cognitive behavioural therapy for the management of inflammatory bowel disease-fatigue with a nested qualitative element: study protocol for a randomised controlled trial. Pilot Feasibility Stud.\u00a02017;18:213 1\u201313.","DOI":"10.1186\/s13063-017-1926-3"},{"key":"829_CR20","doi-asserted-by":"crossref","unstructured":"Williams A, Eccleston C, Morley S. Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database Syst Rev.\u00a02012;11:1\u2013103.","DOI":"10.1002\/14651858.CD007407.pub3"},{"issue":"8","key":"829_CR21","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s10461-016-1397-7","volume":"20","author":"LA Uebelacker","year":"2016","unstructured":"Uebelacker LA, Weisberg RB, Herman DS, Bailey GL, Pinkston-Camp MM, Garnaat SL, et al. Pilot randomized trial of collaborative behavioral treatment for chronic pain and depression in persons living with HIV\/AIDS. AIDS Behav. 2016;20(8):1675\u201381.","journal-title":"AIDS Behav"},{"issue":"1","key":"829_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.7224\/1537-2073.2018-023","volume":"22","author":"ES Gromisch","year":"2019","unstructured":"Gromisch ES, Kerns RD, Czlapinski R, Beenken B, Otis J, Lo AC, et al. Cognitive Behavioral Therapy for the Management of Multiple Sclerosis\u2013Related Pain: A Randomized Clinical Trial. Int J MS Care. 2019;22(1):8\u201314.","journal-title":"Int J MS Care"},{"key":"829_CR23","doi-asserted-by":"crossref","unstructured":"Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, MJB P. Developing and evaluating complex interventions: the new Medical Research Council guidance.\u00a0International journal of nursing studies.\u00a0Int J Nurs Stud.\u00a02008;337(a1655):1\u20136.","DOI":"10.1136\/bmj.a1655"},{"issue":"4","key":"829_CR24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/2049463719844539","volume":"13","author":"L Sweeney","year":"2019","unstructured":"Sweeney L, Moss-Morris R, Czuber-Dochan W, Belotti L, Kabeli Z, Norton C. \u2018It\u2019s about willpower in the end. You\u2019ve got to keep going\u2019: a qualitative study exploring the experience of pain in inflammatory bowel disease. Br J Pain. 2019;13(4):201\u201313.","journal-title":"Br J Pain."},{"issue":"3","key":"829_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/MEG.0000000000001615","volume":"32","author":"L Sweeney","year":"2020","unstructured":"Sweeney L, Moss-Morris R, Czuber-Dochan W, Murrells T, Norton C. Developing a better biopsychosocial understanding of pain in inflammatory bowel disease: a cross-sectional study. Eur J Gastroenterol Hepatol. 2020;32(3):335\u201344.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"829_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40814-016-0058-y","volume":"2","author":"S Levati","year":"2016","unstructured":"Levati S, Campbell P, Frost R, Dougall N, Wells M, Donaldson C, et al. Optimisation of complex health interventions prior to a randomised controlled trial: a scoping review of strategies used. Pilot Feasib Stud. 2016;2:1\u201317.","journal-title":"Pilot Feasib Stud"},{"issue":"2","key":"829_CR27","first-page":"129","volume":"23","author":"C Cleeland","year":"1994","unstructured":"Cleeland C, Ryan K. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med. 1994;23(2):129\u201338.","journal-title":"Ann Acad Med"},{"issue":"2","key":"829_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/PSY.0b013e3181643065","volume":"70","author":"K van Kessel","year":"2008","unstructured":"van Kessel K, Moss-Morris R, Willoughby E, Chalder T, Johnson MH, Robinson E. A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue. Psycho Med. 2008;70(2):205\u201313.","journal-title":"Psycho Med"},{"issue":"3","key":"829_CR29","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/bjhp.12295","volume":"23","author":"M Sekhon","year":"2018","unstructured":"Sekhon M, Cartwright M, Francis JJ. Acceptability of health care interventions: A theoretical framework and proposed research agenda. Br J Health Psychol. 2018;23(3):519\u201331.","journal-title":"Br J Health Psychol"},{"issue":"3","key":"829_CR30","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0895-4356(99)00152-3","volume":"53","author":"C W-y","year":"2000","unstructured":"W-y C, Garratt AM, Russell IT, Williams JG. The UK IBDQ\u2014a British version of the inflammatory bowel disease questionnaire: development and validation. J Clin Epidemiol. 2000;53(3):297\u2013306.","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"829_CR31","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/0016-5085(89)90905-0","volume":"96","author":"G Guyatt","year":"1989","unstructured":"Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, et al. A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology. 1989;96(3):804\u201310.","journal-title":"Gastroenterology."},{"key":"829_CR32","doi-asserted-by":"crossref","unstructured":"Bodger K, Ormerod C, Shackcloth D, MJG H. Development and validation of a rapid, generic measure of disease control from the patient\u2019s perspective: the IBD-control questionnaire. Gut.\u00a02014;63(7):1092\u2013102.","DOI":"10.1136\/gutjnl-2013-305600"},{"issue":"9","key":"829_CR33","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","volume":"16","author":"K Kroenke","year":"2001","unstructured":"Kroenke K, Spitzer RL, Williams JB. The phq-9. J Gen Intern Med. 2001;16(9):606\u201313.","journal-title":"J Gen Intern Med"},{"issue":"1","key":"829_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2036.2004.02007.x","volume":"20","author":"J Labus","year":"2004","unstructured":"Labus J, Bolus R, Chang L, Wiklund I, Naesdal J, Mayer E, et al. The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale. Alimentary Pharmacol Ther. 2004;20(1):89\u201397.","journal-title":"Alimentary Pharmacol Ther"},{"issue":"4","key":"829_CR35","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","volume":"7","author":"MJL Sullivan","year":"1995","unstructured":"Sullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: Development and validation. Psychol Assess. 1995;7(4):524\u201332.","journal-title":"Psychol Assess"},{"issue":"5","key":"829_CR36","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jpsychores.2006.04.018","volume":"61","author":"TN Skerrett","year":"2006","unstructured":"Skerrett TN, Moss-Morris R. Fatigue and social impairment in multiple sclerosis: The role of patients' cognitive and behavioral responses to their symptoms. J Psychos Res. 2006;61(5):587\u201393.","journal-title":"J Psychos Res"},{"key":"829_CR37","unstructured":"Nicholas M, editor Self-efficacy and chronic pain. annual conference of the British Psychological Society St Andrews; 1989."},{"issue":"6","key":"829_CR38","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1002\/jts.20271","volume":"20","author":"L Campbell-Sills","year":"2007","unstructured":"Campbell-Sills L, Stein MB. Psychometric analysis and refinement of the connor\u2013davidson resilience scale (CD-RISC): Validation of a 10-item measure of resilience. J Trauma Stress. 2007;20(6):1019\u201328.","journal-title":"J Trauma Stress"},{"issue":"3","key":"829_CR39","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1177\/0962280215588241","volume":"25","author":"AL Whitehead","year":"2016","unstructured":"Whitehead AL, Julious SA, Cooper CL, Campbell MJ. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Stat Methods Med Res. 2016;25(3):1057\u201373.","journal-title":"Stat Methods Med Res"},{"issue":"2","key":"829_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1191\/1478088706qp063oa","volume":"3","author":"V Braun","year":"2006","unstructured":"Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77\u2013101.","journal-title":"Qual Res Psychol"},{"issue":"4","key":"829_CR41","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1080\/2159676X.2019.1628806","volume":"11","author":"V Braun","year":"2019","unstructured":"Braun V, VJQRiS C. Reflecting on reflexive thematic analysis. Exerc Health. 2019;11(4):589\u201397.","journal-title":"Exerc Health"},{"issue":"4","key":"829_CR42","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0146-6402(78)90002-4","volume":"1","author":"A Bandura","year":"1978","unstructured":"Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Adv Behav Res Ther. 1978;1(4):139\u201361.","journal-title":"Adv Behav Res Ther"},{"issue":"1","key":"829_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12529-017-9678-8","volume":"25","author":"C Ryan","year":"2018","unstructured":"Ryan C, Bergin M, Wells JS. Theoretical perspectives of adherence to web-based interventions: a scoping review. Int J Behav Med. 2018;25(1):17\u201329.","journal-title":"Int J Behav Med"},{"issue":"7","key":"829_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2196\/jmir.4339","volume":"17","author":"D Guertler","year":"2015","unstructured":"Guertler D, Vandelanotte C, Kirwan M, Duncan MJ. Engagement and nonusage attrition with a free physical activity promotion program: the case of 10,000 steps Australia. J Med Internet Res. 2015;17(7):1\u201314.","journal-title":"J Med Internet Res"},{"key":"829_CR45","first-page":"1","volume":"9","author":"SE Knowles","year":"2014","unstructured":"Knowles SE, Toms G, Sanders C, Bee P, Lovell K, Rennick-Egglestone S, et al. Qualitative meta-synthesis of user experience of computerised therapy for depression and anxiety. PLoS One. 2014;9:1\u201312.","journal-title":"PLoS One."},{"issue":"1","key":"829_CR46","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/MIB.0000000000000567","volume":"22","author":"A McCombie","year":"2016","unstructured":"McCombie A, Gearry R, Andrews J, Mulder R, Mikocka-Walus A. Does computerized cognitive behavioral therapy help people with inflammatory bowel disease? A randomized controlled trial. Inflamm Bowel Dis. 2016;22(1):171\u201381.","journal-title":"Inflamm Bowel Dis"},{"key":"829_CR47","doi-asserted-by":"crossref","unstructured":"Leppin AL, Bora PR, Tilburt JC, Gionfriddo MR, Zeballos-Palacios C, Dulohery MM, et al. The efficacy of resiliency training programs: a systematic review and meta-analysis of randomized trials. PLoS One.\u00a02014;9(10):1\u201315.","DOI":"10.1371\/journal.pone.0111420"}],"container-title":["Pilot and Feasibility Studies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40814-021-00829-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40814-021-00829-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40814-021-00829-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T18:19:16Z","timestamp":1619893156000},"score":1,"resource":{"primary":{"URL":"https:\/\/pilotfeasibilitystudies.biomedcentral.com\/articles\/10.1186\/s40814-021-00829-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["829"],"URL":"https:\/\/doi.org\/10.1186\/s40814-021-00829-9","relation":{},"ISSN":["2055-5784"],"issn-type":[{"value":"2055-5784","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]},"assertion":[{"value":"6 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Full ethics approval was received from King\u2019s College London KCL REC Committee, KCL ethics ID: RESCM-18\/19-8806. Eligible participants were provided with a participant information sheet via email with details of the study and given the opportunity to ask any questions. Participants provided informed consent through an online consent form, which was electronically signed and dated by the participant. All participants were given a unique study ID to ensure anonymity.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"L.S. and R.M.M. received funding from the BRC for sample analyses. R.M.M. reports personal fees from training in irritable bowel syndrome intervention for Central and North West London NHS Foundation Trust and University of East Anglia, outside the submitted work. She has received payment for consultancy to Mahana Therapeutics and a private company has signed a licence agreement with King\u2019s College London with the view to bringing the Regul8 website product to the NHS and other international markets. C.N. has received lecture fees from Tillotts Pharma, Abbvie and Ferring Pharmaceuticals. W.C.D. has received lecture fees from Dr Falk Pharma and EGIS Pharmaceuticals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"95"}}