{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:48:26Z","timestamp":1788281306103,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pilot Feasibility Stud"],"DOI":"10.1186\/s40814-024-01580-7","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:23:42Z","timestamp":1736835822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment"],"prefix":"10.1186","volume":"11","author":[{"given":"Juliana V.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Mihalko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Brubaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Leitzelar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna R.","family":"Wolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lee","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Via","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Yazbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhee","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Seegars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ralph","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gregory","family":"Hundley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"1580_CR1","doi-asserted-by":"publisher","unstructured":"Cardinale D, Iacopo F, Cipolla CM. Cardiotoxicity of anthracyclines. Front Cardiovasc Med. 2020;7:26. https:\/\/doi.org\/10.3389\/fcvm.2020.00026.","DOI":"10.3389\/fcvm.2020.00026"},{"issue":"7\u20138","key":"1580_CR2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1159\/000500439","volume":"42","author":"M Gurdogan","year":"2019","unstructured":"Gurdogan M, Ozkan U. A novel predictor of chemotherapeutic cardiotoxicity in patients with non-hodgkin lymphoma. Oncol Res Treat. 2019;42(7\u20138):375\u201381. https:\/\/doi.org\/10.1159\/000500439.","journal-title":"Oncol Res Treat"},{"issue":"3","key":"1580_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3322\/caac.21719","volume":"72","author":"CL Rock","year":"2022","unstructured":"Rock CL, Thomson CA, Sullivan KR, et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin. 2022;72(3):230\u201362. https:\/\/doi.org\/10.3322\/caac.21719.","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"1580_CR4","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","volume":"51","author":"KL Campbell","year":"2019","unstructured":"Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51(11):2375\u201390. https:\/\/doi.org\/10.1249\/MSS.0000000000002116.","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"1580_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11764-014-0413-z","volume":"9","author":"FG Stacey","year":"2015","unstructured":"Stacey FG, James EL, Chapman K, Courneya KS, Lubans DR. A systematic review and meta-analysis of social cognitive theory-based physical activity and\/or nutrition behavior change interventions for cancer survivors. J Cancer Surviv. 2015;9(2):305\u201338. https:\/\/doi.org\/10.1007\/s11764-014-0413-z.","journal-title":"J Cancer Surviv"},{"key":"1580_CR6","doi-asserted-by":"publisher","unstructured":"Scott JM, Haykowsky MJ, Eggebeen J, Morgan TM, Brubaker PH, Kitzman DW. Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction. Am J Cardiol. 2012;S0002\u20139149(12)01944\u20133 [pii]. https:\/\/doi.org\/10.1016\/j.amjcard.2012.08.015.","DOI":"10.1016\/j.amjcard.2012.08.015"},{"issue":"6","key":"1580_CR7","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.amjcard.2008.04.047","volume":"102","author":"DR Bensimhon","year":"2008","unstructured":"Bensimhon DR, Leifer ES, Ellis SJ, et al. Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the heart failure and a controlled trial investigating outcomes of exercise training). Am J Cardiol. 2008;102(6):712\u20137. https:\/\/doi.org\/10.1016\/j.amjcard.2008.04.047.","journal-title":"Am J Cardiol"},{"issue":"3","key":"1580_CR8","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cardfail.2004.09.010","volume":"11","author":"WC Little","year":"2005","unstructured":"Little WC, Zile MR, Kitzman DW, Hundley WG, O\u2019Brien TX, Degroof RC. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail. 2005;11(3):191\u20135. https:\/\/doi.org\/S1071916404009017[pii].","journal-title":"J Card Fail"},{"issue":"11","key":"1580_CR9","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1111\/j.1532-5415.2009.02499.x","volume":"57","author":"PH Brubaker","year":"2009","unstructured":"Brubaker PH, Moore JB, Stewart KP, Wesley DJ, Kitzman DW. Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial. J Am Geriatr Soc. 2009;57(11):1982\u20139. https:\/\/doi.org\/JGS2499[pii]10.1111\/j.1532-5415.2009.02499.x.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"1580_CR10","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.amjcard.2006.01.106","volume":"98","author":"WC Little","year":"2006","unstructured":"Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol. 2006;98(3):383\u20135. https:\/\/doi.org\/10.1016\/j.amjcard.2006.01.106.","journal-title":"Am J Cardiol"},{"issue":"1","key":"1580_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cardfail.2009.08.008","volume":"16","author":"DA Kass","year":"2010","unstructured":"Kass DA, Kitzman DW, Alvarez GE. The restoration of chronotropic competence in heart failure patients with normal ejection fraction (RESET) study: rationale and design. J Card Fail. 2010;16(1):17\u201324. https:\/\/doi.org\/10.1016\/j.cardfail.2009.08.008.","journal-title":"J Card Fail"},{"issue":"1","key":"1580_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1001\/jama.2015.17346","volume":"315","author":"DW Kitzman","year":"2016","unstructured":"Kitzman DW, Brubaker P, Morgan T, et al. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2016;315(1):36\u201346. https:\/\/doi.org\/10.1001\/jama.2015.17346.","journal-title":"JAMA"},{"issue":"7","key":"1580_CR13","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0002-9149(98)00502-5","volume":"82","author":"CT Marburger","year":"1998","unstructured":"Marburger CT, Brubaker PH, Pollock WE, Morgan TM, Kitzman DW. Reproducibility of cardiopulmonary exercise testing in elderly patients with congestive heart failure. Am J Cardiol. 1998;82(7):905\u20139. https:\/\/doi.org\/S0002914998005025[pii].","journal-title":"Am J Cardiol"},{"issue":"25","key":"1580_CR14","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1016\/j.jacc.2012.08.1010","volume":"60","author":"DE Forman","year":"2012","unstructured":"Forman DE, Fleg JL, Kitzman DW, et al. 6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure. J Am Coll Cardiol. 2012;60(25):2653\u201361. https:\/\/doi.org\/10.1016\/j.jacc.2012.08.1010.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1580_CR15","first-page":"919","volume":"132","author":"GH Guyatt","year":"1985","unstructured":"Guyatt GH, Sullivan MJ, Thompson PJ, et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985;132(8):919\u201323.","journal-title":"Can Med Assoc J"},{"issue":"2","key":"1580_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1249\/MSS.0b013e3181ed61a3","volume":"43","author":"L Choi","year":"2011","unstructured":"Choi L, Liu Z, Matthews CE, Buchowski MS. Validation of accelerometer wear and nonwear time classification algorithm. Med Sci Sports Exerc. 2011;43(2):357\u201364. https:\/\/doi.org\/10.1249\/MSS.0b013e3181ed61a3.","journal-title":"Med Sci Sports Exerc"},{"issue":"8","key":"1580_CR17","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.jcmg.2012.11.017","volume":"6","author":"BC Drafts","year":"2013","unstructured":"Drafts BC, Twomley KM, D\u2019Agostino R Jr, et al. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013;6(8):877\u201385. https:\/\/doi.org\/10.1016\/j.jcmg.2012.11.017.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"1580_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jacc.2011.02.055","volume":"58","author":"MJ Haykowsky","year":"2011","unstructured":"Haykowsky MJ, Brubaker PH, John JM, Stewart KP, Morgan TM, Kitzman DW. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol. 2011;58(3):265\u201374. https:\/\/doi.org\/10.1016\/j.jacc.2011.02.055.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1580_CR19","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/S0735-1097(01)01447-4","volume":"38","author":"WG Hundley","year":"2001","unstructured":"Hundley WG, Kitzman DW, Morgan TM, et al. Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol. 2001;38(3):796\u2013802. https:\/\/doi.org\/S0735-1097(01)01447-4[pii].","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"1580_CR20","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/s0002-9149(02)02838-2","volume":"90","author":"P Rerkpattanapipat","year":"2002","unstructured":"Rerkpattanapipat P, Hundley WG, Link KM, et al. Relation of aortic distensibility determined by magnetic resonance imaging in patients > or =60 years of age to systolic heart failure and exercise capacity. Am J Cardiol. 2002;90(11):1221\u20135. https:\/\/doi.org\/10.1016\/s0002-9149(02)02838-2.","journal-title":"Am J Cardiol"},{"key":"1580_CR21","doi-asserted-by":"crossref","unstructured":"Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473\u201383.","DOI":"10.1097\/00005650-199206000-00002"},{"key":"1580_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1477-7525-1-79","volume":"1","author":"K Webster","year":"2003","unstructured":"Webster K, Cella D, Yost K. The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: properties, applications, and interpretation. Health Qual Life Outcomes. 2003;1:79. https:\/\/doi.org\/10.1186\/1477-7525-1-79.","journal-title":"Health Qual Life Outcomes."},{"issue":"2","key":"1580_CR23","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/cncr.10245","volume":"94","author":"D Cella","year":"2002","unstructured":"Cella D, Lai JS, Chang CH, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer. 2002;94(2):528\u201338. https:\/\/doi.org\/10.1002\/cncr.10245.","journal-title":"Cancer"},{"issue":"1","key":"1580_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/annonc\/mdn537","volume":"20","author":"O Minton","year":"2009","unstructured":"Minton O, Stone P. A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Ann Oncol. 2009;20(1):17\u201325. https:\/\/doi.org\/mdn537[pii]10.1093\/annonc\/mdn537.","journal-title":"Ann Oncol"},{"issue":"3","key":"1580_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s11764-018-0675-y","volume":"12","author":"JR Vallerand","year":"2018","unstructured":"Vallerand JR, Rhodes RE, Walker GJ, Courneya KS. Feasibility and preliminary efficacy of an exercise telephone counseling intervention for hematologic cancer survivors: a phase II randomized controlled trial. J Cancer Surviv. 2018;12(3):357\u201370. https:\/\/doi.org\/10.1007\/s11764-018-0675-y.","journal-title":"J Cancer Surviv"},{"issue":"3","key":"1580_CR26","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1080\/10428194.2020.1842396","volume":"62","author":"MC Cox","year":"2021","unstructured":"Cox MC, Nusca SM, Di Landro F, et al. Exercise training (ET) in adult and elderly patients receiving anti-lymphoma treatments is feasible and may improve the provision of care. Leuk Lymphoma. 2021;62(3):560\u201370. https:\/\/doi.org\/10.1080\/10428194.2020.1842396.","journal-title":"Leuk Lymphoma"},{"issue":"27","key":"1580_CR27","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1200\/JCO.2008.20.0634","volume":"27","author":"KS Courneya","year":"2009","unstructured":"Courneya KS, Sellar CM, Stevinson C, et al. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol. 2009;27(27):4605\u201312. https:\/\/doi.org\/10.1200\/JCO.2008.20.0634.","journal-title":"J Clin Oncol"},{"issue":"7","key":"1580_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/medicina55070379","volume":"55","author":"F Fischetti","year":"2019","unstructured":"Fischetti F, Greco G, Cataldi S, Minoia C, Loseto G, Guarini A. Effects of physical exercise intervention on psychological and physical fitness in lymphoma patients. Medicina (Kaunas). 2019;55(7):379. https:\/\/doi.org\/10.3390\/medicina55070379.","journal-title":"Medicina (Kaunas)"},{"key":"1580_CR29","doi-asserted-by":"publisher","unstructured":"De Lazzari N, Niels T, Tewes M, Gotte M. A systematic review of the safety, feasibility and benefits of exercise for patients with advanced cancer. Cancers (Basel). 2021;13(17):4478. https:\/\/doi.org\/10.3390\/cancers13174478.","DOI":"10.3390\/cancers13174478"},{"key":"1580_CR30","doi-asserted-by":"publisher","first-page":"153473542094683","DOI":"10.1177\/1534735420946834","volume":"19","author":"AS Mazzoni","year":"2020","unstructured":"Mazzoni AS, Brooke HL, Berntsen S, Nordin K, Demmelmaier I. Exercise adherence and effect of self-regulatory behavior change techniques in patients undergoing curative cancer treatment: secondary analysis from the phys-can randomized controlled trial. Integr Cancer Ther. 2020;19:1534735420946834. https:\/\/doi.org\/10.1177\/1534735420946834.","journal-title":"Integr Cancer Ther"},{"issue":"1","key":"1580_CR31","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1186\/s12889-019-6877-z","volume":"19","author":"T Bullard","year":"2019","unstructured":"Bullard T, Ji M, An R, Trinh L, Mackenzie M, Mullen SP. A systematic review and meta-analysis of adherence to physical activity interventions among three chronic conditions: cancer, cardiovascular disease, and diabetes. BMC Public Health. 2019;19(1):636. https:\/\/doi.org\/10.1186\/s12889-019-6877-z.","journal-title":"BMC Public Health"},{"issue":"1","key":"1580_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13014-016-0619-5","volume":"11","author":"A Grabenbauer","year":"2016","unstructured":"Grabenbauer A, Grabenbauer AJ, Lengenfelder R, Grabenbauer GG, Distel LV. Feasibility of a 12-month-exercise intervention during and after radiation and chemotherapy in cancer patients: impact on quality of life, peak oxygen consumption, and body composition. Radiat Oncol. 2016;11(1):42. https:\/\/doi.org\/10.1186\/s13014-016-0619-5.","journal-title":"Radiat Oncol"},{"issue":"1","key":"1580_CR33","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1038\/s41598-022-06165-z","volume":"12","author":"MB Kraemer","year":"2022","unstructured":"Kraemer MB, Priolli DG, Reis IGM, Pelosi AC, Garbuio ALP, Messias LHD. Home-based, supervised, and mixed exercise intervention on functional capacity and quality of life of colorectal cancer patients: a meta-analysis. Sci Rep. 2022;12(1):2471. https:\/\/doi.org\/10.1038\/s41598-022-06165-z.","journal-title":"Sci Rep"},{"issue":"2","key":"1580_CR34","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2022-001353","volume":"8","author":"JC Brown","year":"2022","unstructured":"Brown JC, Brighton E, Campbell N, et al. Physical activity in older adults with metastatic gastrointestinal cancer: a pilot and feasibility study. BMJ Open Sport Exerc Med. 2022;8(2): e001353. https:\/\/doi.org\/10.1136\/bmjsem-2022-001353.","journal-title":"BMJ Open Sport Exerc Med"},{"key":"1580_CR35","doi-asserted-by":"publisher","unstructured":"Doshi R, Hiran KK, G\u00f6k M, El-kenawy ESM, Badr A, Abotaleb M. Artificial Intelligence's significance in diseases with malignant tumours. Mesopotamian J Artif Intell Healthcare. 2023:35\u201339. https:\/\/doi.org\/10.58496\/mjaih\/2023\/007.","DOI":"10.58496\/mjaih\/2023\/007"}],"container-title":["Pilot and Feasibility Studies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40814-024-01580-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40814-024-01580-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40814-024-01580-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T18:16:53Z","timestamp":1736878613000},"score":1,"resource":{"primary":{"URL":"https:\/\/pilotfeasibilitystudies.biomedcentral.com\/articles\/10.1186\/s40814-024-01580-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1580"],"URL":"https:\/\/doi.org\/10.1186\/s40814-024-01580-7","relation":{},"ISSN":["2055-5784"],"issn-type":[{"value":"2055-5784","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"11 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Wake Forest University Institutional Review Board (IRB00020968) and registered on ClinicalTrials.gov (NCT01719562).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6"}}