{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:59:05Z","timestamp":1790535545959,"version":"4.1.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The concept of periodontal regeneration has been revolutionised since the introduction of growth factors and bioactive bone substitutes which ensures optimal regeneration of the diseased periodontium. The aim of the present study was to evaluate the efficacy of Amniotic membrane\u2009+\u2009Biphasic Calcium phosphate as compared to Collagen membrane\u2009+\u2009Biphasic Calcium phosphate for the management of periodontal intrabony defects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>50 systemically healthy patients with localised moderate to severe periodontitis, sites which had a Probing Pocket Depth (PPD)\u2009\u2265\u20096 mm and an intrabony component of \u2265\u20093 mm as detected on Intra oral periapical radiographs (IOPAR) and bone sounding were recruited based on specific inclusion and exclusion criteria. They were randomly allocated by computer generated tables to Collagen membrane\u2009+\u2009Biphasic Calcium phosphate and Amniotic membrane\u2009+\u2009Biphasic Calcium phosphate groups. The amount of bone fill and changes in Probing Pocket Depth, Clinical Attachment Level were measured at baseline and six months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results of the present study showed a mean reduction in the PPD of 2.89\u2009\u00b1\u20090.69 mm in the Collagen membrane\u2009+\u2009Biphasic Calcium phosphate group and 2.95\u2009\u00b1\u20090.57 mm in the Amniotic membrane\u2009+\u2009Biphasic Calcium phosphate group and CAL gain of 2.60\u2009\u00b1\u20091.43 mm in Collagen membrane\u2009+\u2009Biphasic Calcium phosphate group 3.18\u2009\u00b1\u20091.13 mm in the Amniotic membrane\u2009+\u2009Biphasic Calcium phosphate group at 6 months follow-up with no statistical significance between the groups. In terms of Defect resolution, 98.62\u2009\u00b1\u20096.51\u2009% was achieved in Collagen membrane\u2009+\u2009Biphasic Calcium phosphate group and 98.25\u2009\u00b1\u20097.21\u2009% in Amniotic membrane\u2009+\u2009Biphasic Calcium phosphate group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Within the limitations of the present study, it can be concluded that AM can be used as a barrier membrane, in conjunction with Biphasic calcium phosphate, and provides comparable results to Collagen membrane with Biphasic calcium phosphate when used in the management of periodontal intrabony defects.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40824-021-00217-7","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T11:02:42Z","timestamp":1620298962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial"],"prefix":"10.34133","volume":"25","author":[{"given":"Nivedha","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Department of Periodontology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamsi","family":"Lavu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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