{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:23:15Z","timestamp":1774354995244,"version":"3.50.1"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870366"],"award-info":[{"award-number":["81870366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81900418"],"award-info":[{"award-number":["81900418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Action Plan in Shanghai","award":["20JC1418700"],"award-info":[{"award-number":["20JC1418700"]}]},{"name":"Dawn Project of Shanghai","award":["19SG31"],"award-info":[{"award-number":["19SG31"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Stent-graft-induced inflammation is an independent risk factor for adverse aortic remodeling in aortic dissection. In this context, we asked that\u00a0whether a methylprednisolone-loaded stent-graft could reduce inflammation and degradation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>First, a coaxial electrospinning technique was used to create a core-shell film with methylprednisolone encapsulated in the inner of poly (L-lactide-co-caprolactone) nanofibers for controllable drug release. Second, an in vitro study was conducted to evaluate the biocompatibility of the nanofiber meshes. Third, the porcine aortic dissection model was developed to investigate the therapeutic effects of the methylprednisolone-loaded stent-graft.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results demonstrated that the nanofiber-coated film with a methylprednisolone-poly-caprolactone core layer and a poly (L-lactide-co-caprolactone) shell layer could effectively sustain drug release in vitro. In vivo study showed that the methylprednisolone-loaded stent-graft could reduce degradtion of aortic dissection by\u00a0regulating inflammation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Overall, the controllable drug\u00a0release by coaxial nanofiber is a promising approach to alleviate\u00a0aortic inflammation and promote aortic remodeling after stent-graft implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40824-022-00259-5","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T10:04:24Z","timestamp":1650881064000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A methylprednisolone-loaded and core-shell nanofiber-covered stent-graft to prevent inflammation and reduce degradation in aortic dissection"],"prefix":"10.34133","volume":"26","author":[{"given":"Junjun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China."},{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China."},{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaiping","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.06.027"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.121"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.53"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01904-y"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.10.058"},{"key":"e_1_3_7_8_2","doi-asserted-by":"crossref","unstructured":"Higashigawa T Ichikawa Y Chino S Nakajima K Ouchi T Kato H et al. 18F-FDG uptake as a predictive factor for progressive aortic enlargement in aortic dissection. 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