{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:10:45Z","timestamp":1794024645716,"version":"4.8.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":99,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Relationship between Oral Health and Chronic Diseases of the Elderly","award":["SSDC-2019-ZDXK01"],"award-info":[{"award-number":["SSDC-2019-ZDXK01"]}]},{"name":"Key Disciplines of Preventive Dentistry","award":["SSDC-2020-CXTD-A03"],"award-info":[{"award-number":["SSDC-2020-CXTD-A03"]}]},{"name":"Youth Fund of the National Health Commission","award":["20194Y0142"],"award-info":[{"award-number":["20194Y0142"]}]},{"name":"the Aging Special Program of the National Health Commission","award":["2020YJZX0117"],"award-info":[{"award-number":["2020YJZX0117"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2032123"],"award-info":[{"award-number":["U2032123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21935002"],"award-info":[{"award-number":["21935002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2023,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteochondral defects pose an enormous challenge without satisfactory repair strategy to date. In particular, the lateral integration of neo-cartilage into the surrounding native cartilage is a difficult and inadequately addressed problem determining tissue repair\u2019s success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Regenerated silk fibroin (RSF) based on small aperture scaffolds was prepared with\n                      <jats:italic>n<\/jats:italic>\n                      -butanol innovatively. Then, the rabbit knee chondrocytes and bone mesenchymal stem cells (BMSCs) were cultured on RSF scaffolds, and after induction of chondrogenic differentiation, cell-scaffold complexes strengthened by a 14 wt% RSF solution were prepared for in vivo experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A porous scaffold and an RSF sealant exhibiting biocompatibility and excellent adhesive properties are developed and confirmed to promote chondrocyte migration and differentiation. Thus, osteochondral repair and superior horizontal integration are achieved in vivo with this composite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, the new approach of marginal sealing around the RSF scaffolds exhibits preeminent repair results, confirming the ability of this novel graft to facilitate simultaneous regeneration of cartilage\u2013subchondral bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40824-023-00370-1","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T02:02:14Z","timestamp":1684461734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regenerated silk fibroin based on small aperture scaffolds and marginal sealing hydrogel for osteochondral defect repair"],"prefix":"10.34133","volume":"27","author":[{"given":"Yinyue","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Stomatological Hospital &amp; School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200001, China."},{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai 200002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Stomatological Hospital &amp; School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200001, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra sufyan","family":"Almaqrami","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Ningbo Dental Hospital, Ningbo 315032, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint and Occlusion, School\/Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu 730013, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhong","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Stomatological Hospital &amp; School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200001, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Stomatological Hospital &amp; School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200001, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Stomatological Hospital &amp; School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200001, China."},{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai 200002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"crossref","unstructured":"Sang S Mao X Cao Y Liu Z Shen Z Li M et al. 3D Bioprinting using synovium-derived MSC-laden photo-cross-linked ECM bioink for cartilage regeneration. 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