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In this paper, we report a rare case of heterotopic pregnancy and perform a literature review. A 30-year-old patient with a history of left adnexectomy presented with persistent lower abdominal pain and hemorrhagic shock after single embryo transfer. Emergency laparoscopic exploration revealed a ruptured mass in the right isthmus of the fallopian tube, for which right salpingectomy was performed. After anti-inflammatory treatment and fetal preservation, the intrauterine pregnancy progressed smoothly, and a healthy baby was delivered at 39 weeks gestation. In this case, the patient\u2019s heterotopic pregnancy was possibly due to a natural pregnancy caused by sexual intercourse during treatment, so we recommend that sexual intercourse be avoided during transfer cycles.<\/jats:p>","DOI":"10.1186\/s40834-024-00266-y","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:04:23Z","timestamp":1706691863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heterotopic pregnancy after a single embryo transfer with successful perinatal outcome: case report and literature review"],"prefix":"10.1186","volume":"9","author":[{"given":"Wanqi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"266_CR1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3390\/medicina56120665","volume":"56","author":"M Oancea","year":"2020","unstructured":"Oancea M, Ciortea R, Diculescu D, Poienar A-A, Grigore M, Lupean R-A, et al. 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