{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:11:01Z","timestamp":1789035061683,"version":"build-2803163510"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR2002A"],"award-info":[{"award-number":["16CR2002A"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR3028A"],"award-info":[{"award-number":["16CR3028A"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR2002A"],"award-info":[{"award-number":["16CR2002A"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR3028A"],"award-info":[{"award-number":["16CR3028A"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472240"],"award-info":[{"award-number":["81472240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773184"],"award-info":[{"award-number":["81773184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Commun"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Gallbladder carcinoma is highly aggressive and resistant to chemotherapy, with no consistent strategy to guide first line chemotherapy. However, patient\u2010derived xenograft (PDX) model has been increasingly used as an effective model for in preclinical study of chemosensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mini\u2010PDX model was established using freshly resected primary lesions from 12 patients with gallbladder to examine the sensitivity with five of the most commonly used chemotherapeutic agents, namely gemcitabine, oxaliplatin, 5\u2010fluorouracil, nanoparticle albumin\u2010bound (nab)\u2010paclitaxel, and irinotecan. The results were used to guide the selection of chemotherapeutic agents for adjunctive treatment after the surgery. Kaplan\u2013Meier method was used to compare overall survival (OS) and disease free survival (DFS) with 45 patients who received conventional chemotherapy with gemcitabine and oxaliplatin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Cell viability assays based on mini\u2010PDX model revealed significant heterogeneities in drug responsiveness. Kaplan\u2013Meier analysis showed that patients in the PDX\u2010guided chemotherapy group had significantly longer median OS (18.6 months; 95% CI 15.9\u201321.3 months) than patients in the conventional chemotherapy group (13.9 months; 95% CI 11.7\u201316.2 months) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.030; HR 3.18; 95% CI 1.47\u20136.91). Patients in the PDX\u2010guided chemotherapy group also had significantly longer median DFS (17.6 months; 95% CI 14.5\u201320.6 months) than patients in the conventional chemotherapy group (12.0 months; 95% CI 9.7\u201314.4 months) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014; HR 3.37; 95% CI 1.67\u20136.79).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">The use of mini\u2010PDX model to guide selection of chemotherapeutic regimens could improve the outcome in patients with gallbladder carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40880-018-0318-8","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T08:24:33Z","timestamp":1531815873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Guided chemotherapy based on patient\u2010derived mini\u2010xenograft models improves survival of gallbladder carcinoma patients"],"prefix":"10.34133","volume":"38","author":[{"given":"Ming","family":"Zhan","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010meng","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u2010wang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010mei","family":"Long","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411807"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.6.349"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010009\u20100538\u2010x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7591"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.1000\u20109604.2015.04.01"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(11)70301\u20101"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(11)70329\u20101"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000445187"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328021"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2014.01.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3375"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201017\u20100245"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.9692"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.009"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201009\u2010672352"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28621"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.530"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.61"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2017.02.07"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2016.04.08"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054\u20103589(08)60263\u2010X"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2016.06.06"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.09.009"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010017\u20100470\u20107"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5381"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3386"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.011.10326"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2007.15"}],"container-title":["Cancer Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40880-018-0318-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40880-018-0318-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1186%2Fs40880-018-0318-8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40880-018-0318-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1186\/s40880-018-0318-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:58:45Z","timestamp":1773824325000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1186\/s40880-018-0318-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1186\/s40880-018-0318-8"],"URL":"https:\/\/doi.org\/10.1186\/s40880-018-0318-8","relation":{},"ISSN":["2523-3548"],"issn-type":[{"value":"2523-3548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,17]]},"assertion":[{"value":"2017-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"48"}}