{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:30:22Z","timestamp":1765888222236,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Maxillofac Plast Reconstr Surg"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:p>Botulinum toxin (BTX) is used in various ways such as temporarily resolving muscular problems in musculoskeletal temporomandibular disorders, inducing a decrease in bruxism through a change in muscular patterns in a patient\u2019s bruxism, and solving problems in patients with tension headache. And also, BTX is widely used in cosmetic applications for the treatment of facial wrinkles after local injection, but conditions such as temporomandibular joint disorders, headache, and neuropathic facial pain could be treated with this drug. In this report, we will discuss the clinical use of BTX for facial wrinkle, intraoral ulcer, and cranio-maxillofacial pain with previous studies and share our case.<\/jats:p>","DOI":"10.1186\/s40902-019-0224-2","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T12:15:44Z","timestamp":1571228144000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Application of botulinum toxin in maxillofacial field: Part II. Wrinkle, intraoral ulcer, and cranio-maxillofacial pain"],"prefix":"10.1186","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-8440","authenticated-orcid":false,"given":"Kyung-Hwan","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Su","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hee","family":"Yeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Gun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"224_CR1","first-page":"1189","volume":"24","author":"A Carruther","year":"1998","unstructured":"Carruther A, Carruthers J (1998) Clinical indications and injections technique for the cosmetic use of botulinum A exotoxin. Dermatol Surg 24:1189\u20131194","journal-title":"Dermatol Surg"},{"key":"224_CR2","first-page":"1181","volume":"24","author":"CL Hankins","year":"1998","unstructured":"Hankins CL, Strimling R, Roger GS (1998) Botulinum A toxin for glabellar wrinkles. Dose and response. Dermatol Surg 24:1181\u20131183","journal-title":"Dose and response. Dermatol Surg"},{"key":"224_CR3","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s00266-002-2047-1","volume":"26","author":"NW Bulstrode","year":"2002","unstructured":"Bulstrode NW, Grobbelaar AO (2002) Long-term prospective follow-up of botulinum toxin treatment for facial rhytides. Aesthetic Plast Surg 26:356\u2013359","journal-title":"Aesthetic Plast Surg"},{"key":"224_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00266-002-2030-x","volume":"26","author":"MA Sarrabayrouse","year":"2002","unstructured":"Sarrabayrouse MA (2002) Indication and limitations for use of botulinum toxin for the treatment of facial wrinkles. Aesthetic Plast Surg 26:233\u2013238","journal-title":"Aesthetic Plast Surg"},{"key":"224_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/bjs.4394","volume":"91","author":"OM Jones","year":"2004","unstructured":"Jones OM, Brading AF, Mortensen NJ (2004) Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg. 91:224\u2013228","journal-title":"Br J Surg."},{"key":"224_CR6","volume-title":"How to use botulinum toxin for treatment","author":"HC Yoon","year":"2002","unstructured":"Yoon HC (2002) How to use botulinum toxin for treatment. Future Publishing, Busan"},{"key":"224_CR7","first-page":"1172","volume":"24","author":"JM Wieder","year":"1998","unstructured":"Wieder JM, Moy RL (1998) Understanding botulinum toxin: surgical anatomy of the frown, foreahead, and periocular region. Dermatol Surg 24:1172\u20131174","journal-title":"Dermatol Surg"},{"key":"224_CR8","volume-title":"Surgical approaches to the facial skeleton","author":"III Edward Ellis","year":"1995","unstructured":"Edward Ellis III, Zide MF (1995) Surgical approaches to the facial skeleton. Wolters Kluwer, Philadelphia"},{"key":"224_CR9","first-page":"1249","volume":"24","author":"SL Matarasso","year":"1998","unstructured":"Matarasso SL (1998) Complications of botulinum A exotoxin for hyperfunctional lines. Dermatol Surg. 24:1249\u20131254","journal-title":"Dermatol Surg."},{"key":"224_CR10","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1046\/j.1365-4362.1999.00722.x","volume":"38","author":"AV Benedetto","year":"1999","unstructured":"Benedetto AV (1999) The cosmetic uses of botulinum toxin type A. Int J Dermatol. 38:641\u2013655","journal-title":"Int J Dermatol."},{"key":"224_CR11","unstructured":"Carruthers J, Carruthers A. (1991) Botulinum toxin use on glabellar wrinkles. Presented at the annual meeting of the American Society for dermatologic surgery Orlando Florida. 13-17 March. 1991."},{"key":"224_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1524-4725.1992.tb03295.x","volume":"18","author":"JD Carruthers","year":"1992","unstructured":"Carruthers JD, Carruthers JA (1992) Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol 18:17\u201321","journal-title":"J Dermatol Surg Oncol"},{"key":"224_CR13","volume-title":"Cosmetic surgery of Asian face","author":"JA McCurdy Jr","year":"1990","unstructured":"McCurdy JA Jr (1990) Cosmetic surgery of Asian face. Thieme Medical Publishers, New York"},{"key":"224_CR14","unstructured":"Price J, O'Day J (1993) A comparative study of tear secretion in blepharospasm and hemifacial spasm patients treated with botulinum toxin. J Clin Neuroophthalmol 13:67-71."},{"key":"224_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s002660010100","volume":"25","author":"C Le Louarn","year":"2001","unstructured":"Le Louarn C (2001) Botulinum toxin A and facial lines: the variable concentration. Aesthetic Plastic Surgery 25:73\u201384","journal-title":"Aesthetic Plastic Surgery"},{"key":"224_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2146\/ajhp050137","volume":"63","author":"CM Cheng","year":"2006","unstructured":"Cheng CM, Chen JS, Patel RP (2006) Unlabeled uses of botulinum toxins: a review, part 1. Am J Health Syst Pharm 63:145\u2013152","journal-title":"Am J Health Syst Pharm"},{"key":"224_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2146\/sp\/06001","volume":"63","author":"CM Cheng","year":"2006","unstructured":"Cheng CM, Chen JS, Patel RP (2006) Unlabeled uses of botulinum toxins: a review, part 2. Am J Health Syst Pharm 63:225\u2013232","journal-title":"Am J Health Syst Pharm"},{"key":"224_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S1042-3699(02)00070-5","volume":"15","author":"E Eisenberg","year":"2003","unstructured":"Eisenberg E (2003) Diagnosis and treatment of recurrent aphthous stomatitis. Oral Maxillofac Surg Clin North Am 15:111\u2013122","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"224_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00405-008-0756-z","volume":"266","author":"TY Yang","year":"2009","unstructured":"Yang TY, Jang TY (2009) The value of local botulinum toxin A injection in the treatment of the pain of aphthous ulcer. Eur Arch Otorhinolaryngol 266:445\u2013448","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"224_CR20","volume-title":"Schoenberg BS (ed) Advances in Neurology","author":"A Leviton","year":"1978","unstructured":"Leviton A (1978) Epidemiology of headaches. In: Schoenberg BS (ed) Advances in Neurology. Raven Press, New York"},{"key":"224_CR21","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1517\/13543784.10.8.1531","volume":"10","author":"GE Borodic","year":"2001","unstructured":"Borodic GE, Acquadro M, Johnson EA (2001) Botulinum toxin therapy for pain and inflammatory disorders: mechanisms and therapeutic effects. Expert Opin Investig Drugs 10:1531\u20131544","journal-title":"Expert Opin Investig Drugs"},{"key":"224_CR22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.14219\/jada.archive.2000.0149","volume":"131","author":"EK Tan","year":"2000","unstructured":"Tan EK, Jankovic J (2000) Treating severe bruxism with botulinum toxin. J Am Dent Assoc 131:211\u2013216","journal-title":"J Am Dent Assoc"},{"key":"224_CR23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1007\/s00296-004-0485-6","volume":"25","author":"A Kamanli","year":"2005","unstructured":"Kamanli A, Kaya A, Ardicoglu O, Ozgocmen S, Zengin FO, Bayik Y (2005) Comparison of lidocaine injection, botulinum toxin injection, and dry needling to trigger points in myofascial pain syndrome. Rheumatol Int 25:604\u2013611","journal-title":"Rheumatol Int"},{"key":"224_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0304-3959(01)00358-X","volume":"94","author":"AH Wheeler","year":"2001","unstructured":"Wheeler AH, Goolkasian P, Gretz SS (2001) Botulinum toxin A for the treatment of chronic neck pain. Pain 94:255\u2013260","journal-title":"Pain"},{"key":"224_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0304-3959(94)90048-5","volume":"59","author":"WP Cheshire","year":"1994","unstructured":"Cheshire WP, Abashian SW, Mann JD (1994) Botulinum toxin in the treatment of myofascial pain syndrome. Pain 59:65\u201369","journal-title":"Pain"},{"key":"224_CR26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1064-7406(03)00076-2","volume":"11","author":"WJ Binder","year":"2003","unstructured":"Binder WJ, Blitzer A (2003) Treatment of migraine headache with botulinum toxin type A. Facial Plast Surg Clin North Am 11:465\u2013475","journal-title":"Facial Plast Surg Clin North Am"},{"key":"224_CR27","first-page":"1","volume":"7","author":"International Headache Society","year":"1988","unstructured":"International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache classification committee of the International Headache Society. Cephalalgia 7:1\u201396","journal-title":"Cephalalgia"},{"key":"224_CR28","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.coms.2007.12.009","volume":"20","author":"JP Okeson","year":"2008","unstructured":"Okeson JP (2008) The classification of orofacial pains. Oral Maxillofac Surg Clin North Am 20:133\u2013144","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"224_CR29","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1067\/mhn.2000.110960","volume":"123","author":"WJ Binder","year":"2000","unstructured":"Binder WJ, Brin MF, Blitzer A, Schoenrock LD, Pogoda JM (2000) Botulinum toxin type A (BOTOX) for treatment of migraine headaches: an open-label study. Otolaryngol Head Neck Surg 123:669\u2013676","journal-title":"Otolaryngol Head Neck Surg"},{"key":"224_CR30","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S0278-2391(99)90007-1","volume":"57","author":"B Freund","year":"1999","unstructured":"Freund B, Schwartz M, Symington JM (1999) The use of botulinum toxin for the treatment of temporomandibular disorders: preliminary findings. J Oral Maxillofac Surg 57:916\u2013920","journal-title":"J Oral Maxillofac Surg"},{"key":"224_CR31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.sdentj.2015.08.002","volume":"28","author":"MS Archana","year":"2016","unstructured":"Archana MS (2016) Toxin yet not toxic: botulinum toxin in dentistry. Saudi Dent J 28:63\u201369","journal-title":"Saudi Dent J"},{"key":"224_CR32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.disamonth.2009.01.001","volume":"55","author":"DW Lu","year":"2009","unstructured":"Lu DW, Lippitz J (2009) Complications of botulinum neurotoxin. Dis Mon 55:198\u2013211","journal-title":"Dis Mon"},{"key":"224_CR33","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1053\/joms.2003.50069","volume":"61","author":"J Niamtu 3rd","year":"2003","unstructured":"Niamtu J 3rd (2003) Botulinum toxin A: a review of 1,085 oral and maxillofacial patient treatments. J Oral Maxillofac Surg 61:317\u2013324","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Maxillofacial Plastic and Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40902-019-0224-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40902-019-0224-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40902-019-0224-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T23:09:41Z","timestamp":1602716981000},"score":1,"resource":{"primary":{"URL":"https:\/\/jkamprs.springeropen.com\/articles\/10.1186\/s40902-019-0224-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["224"],"URL":"https:\/\/doi.org\/10.1186\/s40902-019-0224-2","relation":{},"ISSN":["2288-8586"],"issn-type":[{"type":"electronic","value":"2288-8586"}],"subject":[],"published":{"date-parts":[[2019,10,16]]},"assertion":[{"value":"14 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}