{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T16:03:08Z","timestamp":1788624188539,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Maxillofac Plast Reconstr Surg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>There is no study on the effectiveness of hyaluronic acid (HA) placement either with or without absorbable collagen sponge (ACS) in reducing or preventing bisphosphonate-related osteonecrosis of the jaws (BRONJ). This preliminary animal study examined the efficacy of this clinically important treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>For simulating BRONJ, zoledronic acid was administered to 40 rats for 5 weeks. Two weeks later, a right first molar was extracted from each rat. The rats were randomized into four groups of socket treatments: control (empty extraction socket) or with sockets filled with ACS, HA, or HA+ACS (<jats:italic>n<\/jats:italic>=4\u00d710). After 2 weeks, 5 rats in each group were sacrificed and subjected to histopathologic and histomorphometric evaluation. Eight weeks post-surgically, the rest of rats were euthanized and histologically examined. The Kruskal-Wallis test was used to compare the four treatments at each time point (<jats:italic>\u03b1<\/jats:italic>=0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Six rats were lost overall. In the second week, vascularization was higher in ACS group (<jats:italic>P<\/jats:italic>&lt;0.05); osteoclast activity was not different between groups (<jats:italic>P<\/jats:italic>&gt;0.05); empty lacunae were the most and fewest in control and HA+ACS groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); eosinophil infiltration was maximum in HA group (<jats:italic>P<\/jats:italic>&lt;0.05); lymphocyte counts were maximum and minimum in the HA+ACS and ACS groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); the highest and lowest neutrophil counts were seen in ACS and control groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); and the extent of live bone did not differ between groups (<jats:italic>P<\/jats:italic>&gt;0.05). In the eighth week, vascularization was not different in groups (<jats:italic>P<\/jats:italic>&gt;0.05); the highest and lowest osteoclast activities were seen in the control and HA+ACS groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); empty lacunae were the most and fewest in control and HA+ACS, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); maximum and minimum numbers of eosinophils were in control and HA+ACS groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); HA and control groups exhibited the highest and lowest lymphocyte counts, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); the lowest and highest neutrophil counts were observed in HA+ACs and control groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05); and the highest and lowest extents of the live bone were observed in HA+ACS and control groups, respectively (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Within the limitations of this preliminary animal study, HA and especially HA+ACS seem a proper method for preventing or treating BRONJ.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40902-022-00337-7","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T11:03:25Z","timestamp":1646132605000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of hyaluronic acid, absorbable collagen sponge, and their combination in minimizing bisphosphonate-related osteonecrosis of the jaws (BRONJ) after dental extraction: a preliminary animal histomorphometric study"],"prefix":"10.1186","volume":"44","author":[{"given":"Farzin","family":"Sarkarat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-4298","authenticated-orcid":false,"given":"Alireza","family":"Modarresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arefeh","family":"Riyahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Mortazavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Tabandeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Rakhshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"issue":"7","key":"337_CR1","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1038\/sj.bdj.2013.327","volume":"214","author":"T Taylor","year":"2013","unstructured":"Taylor T, Bryant C, Popat S (2013) A study of 225 patients on bisphosphonates presenting to the bisphosphonate clinic at King\u2019s College Hospital. 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