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The study of macular changes in high myopia patients has undergone great advances with updated technology via new spectral optical coherence tomography (OCT) and Optical coherence tomography angiography (OCTA). Most of related studies have focused on the adults and additional studies need to investigate macular changes in children and adolescents. This study aimed to evaluate the changes in the macular structure by OCT and the macular vessel density in high myopia in children and adolescents by OCTA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional comparative study. The population was divided into two groups: group 1 (4\u201311 years) and group 2 (12\u201318 years). The results were comparable to those of control study of the same age group. The two high myopia groups and the control groups were examined by macular OCT and OCTA to evaluate macular thickness and vessel density in the superficial and deep capillary plexuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OCT measurements of patients in group 1 revealed that central macular thickness was significantly lower in high myopia group than in the control group and measured 220.91\u2009\u00b1\u200927.87\u00a0\u03bcm and 258.23\u2009\u00b1\u200917.26\u00a0\u03bcm, respectively, (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). However, in group 2 the central macular thickness in the high myopia group and control group was 236.32\u2009\u00b1\u200927.76\u00a0\u03bcm and 247.09\u2009\u00b1\u200916.81\u00a0\u03bcm respectively, and the difference was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.09). The parafoveal macular thickness and the perifoveal macular quadrants thickness were significantly lower in high myopic children and high myopic adolescents (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) than age matched controls. The parafoveal and perifoveal vessel densities in the superficial and deep capillary plexuses were lower in the high myopia groups than in the age-matched controls in both groups with a few segment exceptions in group 1. The FAZ was significantly wider in group 1 than in the age-matched emmetropes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). The FAZ was wider in group 2 than controls, but the difference was not statistically significant, (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High myopic children and adolescents have thinner macular thickness than comparable age-matched emmetropes and have less vessel density in superficial and deep capillary plexuses with a wider FAZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40942-024-00532-w","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T09:02:41Z","timestamp":1707123761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Optical coherence tomography angiography of the macula of high myopia in children and adolescents"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-6856","authenticated-orcid":false,"given":"Marwa Mahmoud","family":"Abdellah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ali","family":"Amer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeiad Hasan","family":"Eldaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Abdellatif","family":"Anber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"532_CR1","doi-asserted-by":"crossref","unstructured":"Chua SYL, Sabanayagam C, Cheung Y-B, Chia A, Valenzuela RK, Tan D et al. 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