{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T16:05:49Z","timestamp":1794413149435,"version":"4.9.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Retin Vitr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This review aims to substantiate the correlation between vitamin D and retinal vein occlusion (RVO) within the medical literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>A systematic review and meta-analysis were conducted in PubMed, SCOPUS, Web of Science, and Embase until December 10th, 2023. A meticulous literature search was undertaken to identify and analyze all observational-analytical papers reporting vitamin D levels in RVO patients. The principal outcome measures centered on the comparative assessment of vitamin D levels between patients with RVO (cases) and those devoid of RVO (controls). The protocol was registered in PROSPERO (code: CRD42024499853).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of six relevant studies consisting of 589 participants were included in this meta-analysis. The results indicated a significant association between vitamin D deficiency and increased risk of RVO (Odds ratio\u2009=\u200914.51; 95% CI: [1.71, 122.59], <jats:italic>P<\/jats:italic>\u2009=\u20090.014); and patients with RVO exhibited a significant decrease in serum vitamin D levels by 1.91ng\/mL (95% CI: [-2.29, -1.54], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Moreover, there was no significant difference observed in vitamin D levels between central RVO (CRVO) and branch RVO (BRVO) subtypes (<jats:italic>P<\/jats:italic>\u2009=\u20090.63).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>RVO patients have more vitamin D deficiency than healthy controls. These results contribute to the growing body of evidence highlighting the intricate role of vitamin D supplementation as both a prophylactic and a treatment strategy in RVO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>PROSPERO registration identifier<\/jats:title>\n                <jats:p>: CRD42024499853.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40942-024-00571-3","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T06:02:55Z","timestamp":1722060175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D deficiency in patients with retinal vein occlusion: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0394-9944","authenticated-orcid":false,"given":"Kimia","family":"Daneshvar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Akhlaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shila","family":"Iranpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-9652","authenticated-orcid":false,"given":"Matin","family":"Irajpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-8209","authenticated-orcid":false,"given":"Mohsen","family":"Pourazizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"issue":"5","key":"571_CR1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1001\/archopht.124.5.726","volume":"124","author":"S Cugati","year":"2006","unstructured":"Cugati S, Wang JJ, Rochtchina E, Mitchell P. 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