{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:52:41Z","timestamp":1790617961055,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Retin Vitr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Cystoid macular edema (CME) can develop following silicone oil placement in complex vitreoretinal surgeries, contributing to poor visual outcomes. In this study, we investigated the clinical and surgical characteristics associated with the development of CME following the use of silicone oil (SO) in pars plana vitrectomy (PPV) surgeries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a retrospective chart review of patients who underwent implantation of SO during PPV from 2010 to 2020 by a single surgeon. Patient demographics, type of oil, duration of oil tamponade, retinectomy size, diabetic status, lens status, prior panretinal photocoagulation, visual acuity, and incidence of CME were reviewed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This study included 43 eyes from 40 patients who underwent SO tamponade for retinal detachment (RD) surgery. The mean duration of SO tamponade was 15.7\u2009\u00b1\u200912.7 months (range: 1\u201358 months). The most common indication for surgery was diabetic tractional RD (32.7%), followed by traumatic RD (16.3%) and rhegmatogenous RD with proliferative vitreoretinopathy (11.6%). Of the 43 eyes, 18 (41.9%) developed CME for the first time after PPV with SO placement, with 8 (44%) resolving within a year of oil removal. The mean duration for the development of CME was 9 months. A logistic regression model showed that a scleral buckle procedure and poor initial vision were statistically significant factors for predicting the development of CME (ORs: 11.65 and 16.06, respectively). Overall, 91% of the patients had stable or improved vision after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The use of a scleral buckle procedure and poor initial vision are significant factors for predicting CME following silicone oil tamponade in PPV surgeries, with 41.9% of patients developing CME with an average duration of 9 months. Recognizing such factors can lead to early monitoring and prompt management of CME.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Meeting presentation<\/jats:title>\n                <jats:p>Partial analyses were presented at the ASRS 2020 conference.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial number<\/jats:title>\n                <jats:p>Not applicable.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40942-024-00582-0","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:03:32Z","timestamp":1726142612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors affecting the development of cystoid macular edema following pars plana vitrectomy with silicone oil placement: a retrospective cohort study"],"prefix":"10.1186","volume":"10","author":[{"given":"Reem H.","family":"ElSheikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sairi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Z.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley N.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami H.","family":"Uwaydat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"2","key":"582_CR1","first-page":"Cd006126","volume":"2","author":"SG Schwartz","year":"2014","unstructured":"Schwartz SG, Flynn HW Jr., Lee WH, Wang X. Tamponade in surgery for retinal detachment associated with proliferative vitreoretinopathy. Cochrane Database Syst Rev. 2014;2(2):Cd006126.","journal-title":"Cochrane Database Syst Rev"},{"key":"582_CR2","doi-asserted-by":"crossref","unstructured":"Krzystolik MG, D\u2019Amico DJ. Complications of intraocular tamponade: silicone oil versus intraocular gas. Int Ophthalmol Clin 2000;40(1).","DOI":"10.1097\/00004397-200040010-00018"},{"issue":"2","key":"582_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/00006982-200104000-00002","volume":"21","author":"EC La Heij","year":"2001","unstructured":"La Heij EC, Hendrikse F, Kessels AG. Results and complications of temporary silicone oil tamponade in patients with complicated retinal detachments. Retina. 2001;21(2):107\u201314.","journal-title":"Retina"},{"issue":"4","key":"582_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.oret.2019.09.015","volume":"4","author":"AM Elhusseiny","year":"2020","unstructured":"Elhusseiny AM, Schwartz SG, Flynn HW Jr., Smiddy WE. Long-term outcomes after Macular Hole surgery. Ophthalmol Retina. 2020;4(4):369\u201376.","journal-title":"Ophthalmol Retina"},{"key":"582_CR5","doi-asserted-by":"crossref","unstructured":"Nicolai M, Lassandro N, Franceschi A et al. Intraocular pressure rise linked to silicone oil in retinal surgery: a review. Vis (Basel) 2020;4(3).","DOI":"10.3390\/vision4030036"},{"issue":"3","key":"582_CR6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1001\/archopht.1997.01100150337005","volume":"115","author":"GW Abrams","year":"1997","unstructured":"Abrams GW, Azen SP, McCuen BW 2, et al. Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone study report 11. Arch Ophthalmol. 1997;115(3):335\u201344.","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"582_CR7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3341\/kjo.2017.0050","volume":"32","author":"JY Yang","year":"2018","unstructured":"Yang JY, Kim HK, Kim SH, Kim SS. Incidence and risk factors of Cystoid Macular Edema after Vitrectomy with Silicone Oil Tamponade for Retinal detachment. Korean J Ophthalmol. 2018;32(3):204\u201310.","journal-title":"Korean J Ophthalmol"},{"key":"582_CR8","doi-asserted-by":"publisher","first-page":"4256183","DOI":"10.1155\/2016\/4256183","volume":"2016","author":"S Takahashi","year":"2016","unstructured":"Takahashi S, Adachi K, Suzuki Y, et al. Profiles of inflammatory cytokines in the vitreous fluid from patients with Rhegmatogenous Retinal detachment and their correlations with clinical features. Biomed Res Int. 2016;2016:4256183.","journal-title":"Biomed Res Int"},{"issue":"2","key":"582_CR9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/ceo.12638","volume":"44","author":"R Gu","year":"2016","unstructured":"Gu R, Zhou M, Jiang C, et al. Elevated concentration of cytokines in aqueous in post-vitrectomy eyes. Clin Exp Ophthalmol. 2016;44(2):128\u201334.","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"582_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/09273948.2019.1652330","volume":"29","author":"I Chatziralli","year":"2021","unstructured":"Chatziralli I, Theodossiadis G, Dimitriou E, et al. Macular Edema after successful pars Plana Vitrectomy for Rhegmatogenous Retinal detachment: factors affecting Edema Development and considerations for treatment. Ocul Immunol Inflamm. 2021;29(1):187\u201392.","journal-title":"Ocul Immunol Inflamm"},{"key":"582_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.preteyeres.2015.07.005","volume":"51","author":"JC Pastor","year":"2016","unstructured":"Pastor JC, Rojas J, Pastor-Idoate S, et al. Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences. Prog Retin Eye Res. 2016;51:125\u201355.","journal-title":"Prog Retin Eye Res"},{"key":"582_CR12","doi-asserted-by":"publisher","first-page":"815937","DOI":"10.1155\/2012\/815937","volume":"2012","author":"SN Moysidis","year":"2012","unstructured":"Moysidis SN, Thanos A, Vavvas DG. Mechanisms of inflammation in proliferative vitreoretinopathy: from bench to bedside. Mediators Inflamm. 2012;2012:815937.","journal-title":"Mediators Inflamm"},{"key":"582_CR13","doi-asserted-by":"crossref","unstructured":"Merad M, Verite F, Baudin F et al. Cystoid Macular Edema after Rhegmatogenous Retinal Detachment Repair with pars Plana Vitrectomy: rate, risk factors, and outcomes. J Clin Med 2022;11(16).","DOI":"10.3390\/jcm11164914"},{"issue":"12","key":"582_CR14","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1080\/02713683.2021.1929330","volume":"46","author":"MR Starr","year":"2021","unstructured":"Starr MR, Cai L, Obeid A, et al. Risk factors for Presence of Cystoid Macular Edema following Rhegmatogenous Retinal detachment surgery. Curr Eye Res. 2021;46(12):1867\u201375.","journal-title":"Curr Eye Res"},{"issue":"11","key":"582_CR15","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1136\/bjo.2003.040402","volume":"88","author":"RH Asaria","year":"2004","unstructured":"Asaria RH, Kon CH, Bunce C, et al. Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid. Br J Ophthalmol. 2004;88(11):1439\u201342.","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"582_CR16","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1097\/IAE.0b013e318246907c","volume":"32","author":"SH Bae","year":"2012","unstructured":"Bae SH, Hwang JS, Yu HG. Comparative analysis of macular microstructure by spectral-domain optical coherence tomography before and after silicone oil removal. Retina. 2012;32(9):1874\u201383.","journal-title":"Retina"},{"issue":"5","key":"582_CR17","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1097\/IAE.0b013e318227ab39","volume":"32","author":"A Almony","year":"2012","unstructured":"Almony A, Nudleman E, Shah GK, Blinder KJ, Eliott DB, Mittra RA, Tewari A. Techniques, rationale, and outcomes of internal limiting membrane peeling. Retina. 2012;32(5):877\u201391.","journal-title":"Retina"},{"key":"582_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.2147\/OPTH.S400474","volume":"17","author":"V Patel","year":"2023","unstructured":"Patel V, Rohowetz LJ, Pakravan P, Kalavar M, Yannuzzi NA, Sridhar J. Outcomes of pars Plana Vitrectomy with Panretinal Photocoagulation for treatment of proliferative Diabetic Retinopathy without Retinal detachment: a seven-year retrospective study. Clin Ophthalmol. 2023;17:471\u20138.","journal-title":"Clin Ophthalmol"},{"key":"582_CR19","doi-asserted-by":"crossref","unstructured":"Stopa M, Kociecki J. Anatomy and function of the macula in patients after retinectomy for retinal detachment complicated by proliferative vitreoretinopathy. Eur J Ophthalmol. 2011 Jul-Aug;21(4):468\u201372.","DOI":"10.5301\/EJO.2010.6069"},{"issue":"6","key":"582_CR20","first-page":"1005","volume":"7","author":"E Karahan","year":"2014","unstructured":"Karahan E, Tuncer I, Zengin MO, et al. Spontaneous resolution of macular edema after silicone oil removal. Int J Ophthalmol. 2014;7(6):1005\u20139.","journal-title":"Int J Ophthalmol"},{"issue":"1","key":"582_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40942-020-00254-9","volume":"7","author":"C Pole","year":"2021","unstructured":"Pole C, Chehaibou I, Govetto A, et al. Macular edema after rhegmatogenous retinal detachment repair: risk factors, OCT analysis, and treatment responses. Int J Retina Vitreous. 2021;7(1):9.","journal-title":"Int J Retina Vitreous"},{"issue":"5","key":"582_CR22","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.oret.2023.11.013","volume":"8","author":"YS Shah","year":"2024","unstructured":"Shah YS, Abidi M, Ahmed I, et al. Risk factors Associated with Cystoid Macular Edema among patients undergoing primary repair of Rhegmatogenous Retinal detachment. Ophthalmol Retina. 2024;8(5):456\u201364.","journal-title":"Ophthalmol Retina"},{"issue":"3","key":"582_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/aos.14940","volume":"100","author":"M Gebler","year":"2022","unstructured":"Gebler M, Pfeiffer S, Callizo J, et al. Incidence and risk factors for macular oedema after primary rhegmatogenous retinal detachment surgery: a prospective single-centre study. Acta Ophthalmol. 2022;100(3):295\u2013301.","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"582_CR24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00417-014-2655-x","volume":"253","author":"R Frisina","year":"2015","unstructured":"Frisina R, Pinackatt SJ, Sartore M, et al. Cystoid macular edema after pars plana vitrectomy for idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol. 2015;253(1):47\u201356.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"582_CR25","doi-asserted-by":"crossref","unstructured":"Banker TP, Reilly GS, Jalaj S, et al. Epiretinal membrane and cystoid macular edema after retinal detachment repair with small-gauge pars plana vitrectomy. Eur J Ophthalmol. 2015 Nov-Dec;25(6):565\u201370.","DOI":"10.5301\/ejo.5000609"},{"key":"582_CR26","doi-asserted-by":"publisher","first-page":"S256","DOI":"10.1111\/j.1755-3768.2016.0298","volume":"94","author":"JP Berrod","year":"2016","unstructured":"Berrod JP, El Kouhen N, Leroy BP, Conart JB. Incidence and risk factors of cystoid macular edema after retinal detachment surgery. Acta Ophthalmol. 2016;94:S256.","journal-title":"Acta Ophthalmol"}],"container-title":["International Journal of Retina and Vitreous"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40942-024-00582-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40942-024-00582-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40942-024-00582-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:05:35Z","timestamp":1726142735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalretinavitreous.biomedcentral.com\/articles\/10.1186\/s40942-024-00582-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["582"],"URL":"https:\/\/doi.org\/10.1186\/s40942-024-00582-0","relation":{},"ISSN":["2056-9920"],"issn-type":[{"value":"2056-9920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"6 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board (IRB) of the University of Arkansas for Medical Sciences (UAMS). The study complied with the Health Insurance Portability and Accountability Act (HIPAA) and adhered to the tenets of the 2013 version of the Declaration of Helsinki. Informed consent to participate in the study was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}