{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:14:17Z","timestamp":1793902457109,"version":"4.8.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Retin Vitr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is evident that the physiopathological pathways of ocular and renal microvascular tissues in patients with systemic lupus are similar. Previously, this was confirmed by employing traditional fundus examination, optical coherence tomography, and high-resolution color electroretinography. Recent years have seen the development of Optical Coherence Tomography Angiography (OCTA) as a non-intrusive procedure that can be employed to image the microvasculature of the retina and choroid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to assess the correlation between renal functional and histologic features with the retinal microvasculature alterations in systemic lupus patients through OCTA analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This case-control study enrolled thirty-six eyes from 18 lupus nephritis (LN) patients, thirty-six eyes from 18 systemic lupus erythematosus (SLE) patients, and thirty eyes from 15 healthy controls. An ophthalmological evaluation, including history, examination, and investigations, was conducted using OCTA for all participants. Prior to ocular examination and investigation, all SLE patients underwent a rheumatological evaluation, encompassing disease-related clinical and laboratory assessments. Specimen retrieval and renal biopsy examinations were also performed, categorizing them into lupus and lupus nephritis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding central foveal thickness (CFT) and parafoveal thickness (PFT), there were no significant differences compared to healthy subjects. A comparison of the foveal avascular zone area (FAZ-A) among the three groups revealed a significant increase in both patient groups compared to healthy controls. Whole superficial capillary plexus (SCP) vascular density (VD) in the parafoveal and foveal regions showed a significant reduction in both SLE patient groups compared to healthy controls (HC). Specifically, SCP values were 42.65\u2009\u00b1\u20092.23% in the SLE with nephritis group, 44.88\u2009\u00b1\u20092.09% in the SLE without nephritis group, and 49.10\u2009\u00b1\u20093.12% in the healthy control group. SCP parafoveal VD values were 40.77\u2009\u00b1\u20093.27% in SLE with nephritis, 47.19\u2009\u00b1\u20092.63% in SLE without nephritis, and 50.98\u2009\u00b1\u20094.80% in healthy controls. SCP foveal VD was 18.96\u2009\u00b1\u20093.43% in SLE with nephritis, 21.61\u2009\u00b1\u20094.00% in SLE without nephritis, and 24.16\u2009\u00b1\u20092.69% in healthy controls. The whole deep capillary plexus (DCP), parafoveal, and foveal VD were significantly reduced in the SLE with nephritis group but showed only marginal differences in the SLE without nephritis group compared to healthy controls, as DCP values were 48.04\u2009\u00b1\u20093.93% in SLE with nephritis, 53.63\u2009\u00b1\u20092.19% in SLE without nephritis, and 54.88\u2009\u00b1\u20093.57% in healthy controls. DCP parafoveal VD was 54.56\u2009\u00b1\u20092.37% in SLE with nephritis, 56.93\u2009\u00b1\u20091.90% in SLE without nephritis, and 57.39\u2009\u00b1\u20095.99% in healthy controls. DCP foveal VD was 34.42\u2009\u00b1\u20093.12% in SLE with nephritis, 41.96\u2009\u00b1\u20093.19% in SLE without nephritis, and 42.55\u2009\u00b1\u20097.74% in healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OCT angiography has a considerable role in the detection of the early changes of the retinal vascular plexus in patients with SLE, especially those with lupus nephritis, even before the development of retinopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40942-025-00677-2","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:39:26Z","timestamp":1746682766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of retinal microvascular changes in patients with systemic lupus erythematosus using optical coherence tomography angiography"],"prefix":"10.1186","volume":"11","author":[{"given":"Ahmed Ibrahim","family":"Basiony","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh Mohamed","family":"Elgouhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeer Elbasuony","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas Sobhy","family":"Zahran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"677_CR1","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1136\/annrheumdis-2020-216924","volume":"79","author":"A Fanouriakis","year":"2020","unstructured":"Fanouriakis A, Kostopoulou M, Chee MAK, et al. 2019 Update of the joint European league against rheumatism and European renal association\u2013European Dialysis and transplant association (EULAR\/ERA EDTA) recommendations for the management of lupus nephritis. 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