{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:51:47Z","timestamp":1781643107465,"version":"3.54.5"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Retin Vitr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the technical feasibility of a standardized, sclerotomy-free method for injecting viscoelastic material into the suprachoroidal space using a novel mechanical injector, and to evaluate an upgraded injector version in an ex vivo porcine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This laboratory investigation was conducted at a central medical research center using thirteen freshly enucleated pig eyes obtained from a local farm. All eyes underwent a 360-degree peritomy and were fixed to a Styrofoam platform. In cohort 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), a custom mechanical injector (Supra SEG) with a 30-gauge needle and selectable penetration depths (0.7\u00a0mm and 0.9\u00a0mm) was used to inject saline or viscoelastic materials (Biolon Prime, Healon 5 Pro, and Healon EndoCoat) into the suprachoroidal space (SCS). In cohort 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), an upgraded injector (27-gauge needle and larger-diameter tubing) was evaluated using the 0.9\u00a0mm depth. Ultrasound biomicroscopy (UBM) was performed before and after each injection to confirm SCS localization. The primary outcome was successful UBM-verified delivery into the SCS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In cohort 1, injections at 0.7\u00a0mm were unsuccessful in all attempts, whereas 0.9\u00a0mm enabled correct SCS delivery in all eyes. In cohort 2, successful UBM-confirmed suprachoroidal delivery was achieved in all eight eyes across multiple viscoelastic materials, including sequential and repeat injections that produced a larger, merged suprachoroidal bleb. UBM demonstrated characteristic echogenic appearances for each material. Injection resistance in cohort 2 was consistently mild to moderate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A sclerotomy-free, image-guided, tangential suprachoroidal injection technique using a purpose-built injector is technically feasible in ex vivo porcine eyes. Because this post-mortem model cannot adequately assess hemorrhagic complications, procedural safety and clinical performance require further in vivo evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40942-026-00831-4","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:52:23Z","timestamp":1773226343000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simplified suprachoroidal buckling: sclerotomy-free viscoelastic injection with a novel device in porcine eyes"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-4295","authenticated-orcid":false,"given":"Yariv","family":"Keshet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Ben-Arzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Gal-Or","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roee","family":"Arnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Dotan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"11","key":"831_CR1","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/S0161-6420(86)33553-X","volume":"93","author":"TA Poole","year":"1986","unstructured":"Poole TA, Sudarsky RD. Suprachoroidal implantation for the treatment of retinal detachment. Ophthalmology. 1986;93(11):1408\u201312.","journal-title":"Ophthalmology"},{"key":"831_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40942-020-00211-6","volume":"6","author":"F Antaki","year":"2020","unstructured":"Antaki F, Dirani A, Ciongoli MR, Steel DHW, Rezende F. Hemorrhagic complications associated with suprachoroidal buckling. Int J Retina Vitreous. 2020;6:10.","journal-title":"Int J Retina Vitreous"},{"issue":"4","key":"831_CR3","first-page":"393","volume":"8","author":"EN El Rayes","year":"2013","unstructured":"El Rayes EN, Elborgy E. Suprachoroidal buckling: technique and indications. J Ophthalmic Vis Res. 2013;8(4):393\u20139.","journal-title":"J Ophthalmic Vis Res"},{"issue":"4","key":"831_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00006982-198500540-00009","volume":"5","author":"ST Charles","year":"1985","unstructured":"Charles ST. 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