{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:32:45Z","timestamp":1786447965811,"version":"build-2736575974"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Retin Vitr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We compared air and gas tamponade for idiopathic full-thickness macular hole (FTMH) surgery with a 24-hour face-down protocol, in a bicentric, retrospective real-world series of 36 air- and 19 gas-treated eyes. Allocation was non-random (gas predominated earlier, air later). Preoperative symptom duration was short in both groups (median 1 [1\u20132] months); median hole diameter was 456 [312\u2013611] \u00b5m (air) and 497 [364\u2013776] \u00b5m (gas;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.40). FTMH closure at 1 month was 100% (36\/36) with air and 94.7% (18\/19) with gas (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.35), reaching 100% in both groups at 3 and 6 months. Best-corrected visual acuity improved significantly within each group, with no significant between-group difference at any timepoint. No complications occurred with air, whereas peripheral retinal breaks occurred only in the gas group. The air group was younger than the gas group (66.1 vs. 74.4 years;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018). Air was associated with anatomical and functional outcomes comparable to gas in this cohort; however, the non-random allocation, small sample, absence of a pre-specified margin and limited statistical power preclude any formal non-inferiority conclusion. Air with short positioning appears a practical alternative to gas in sub-acute holes across the size spectrum, warranting prospective confirmation.\n                  <\/jats:p>","DOI":"10.1186\/s40942-026-00908-0","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:50:30Z","timestamp":1786445430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Air versus long-acting gas tamponade for idiopathic macular hole surgery with 24-hour face-down positioning: a bicentric retrospective study"],"prefix":"10.1186","volume":"12","author":[{"given":"Benjamin","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Parrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Lorenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"2","key":"908_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00417-016-3438-3","volume":"255","author":"A Kontos","year":"2017","unstructured":"Kontos A, Tee J, Stuart A, Shalchi Z, Williamson TH. Duration of intraocular gases following vitreoretinal surgery. Graefes Arch Clin Exp Ophthalmol. 2017;255(2):231\u20136.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"908_CR2","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s10384-020-00714-7","volume":"64","author":"JJ Lee","year":"2020","unstructured":"Lee JJ, Kwon HJ, Lee SM, Byon IS, Lee JE, Park SW. Duration of room air tamponade after vitrectomy. Jpn J Ophthalmol. 2020;64(2):216\u201322.","journal-title":"Jpn J Ophthalmol"},{"issue":"7","key":"908_CR3","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/S0161-6420(99)00730-7","volume":"106","author":"DW Park","year":"1999","unstructured":"Park DW, Sipperley JO, Sneed SR, Dugel PU, Jacobsen J. Macular hole surgery with internal-limiting membrane peeling and intravitreous air. Ophthalmology. 1999;106(7):1392\u20138.","journal-title":"Ophthalmology"},{"issue":"11","key":"908_CR4","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s00417-009-1120-8","volume":"247","author":"Y Hasegawa","year":"2009","unstructured":"Hasegawa Y, Hata Y, Mochizuki Y, et al. Equivalent tamponade by room air as compared with SF6 after macular hole surgery. Graefes Arch Clin Exp Ophthalmol. 2009;247(11):1455\u20139.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"908_CR5","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1097\/IAE.0000000000001413","volume":"37","author":"VA Forsaa","year":"2017","unstructured":"Forsaa VA, Krohn J. Air tamponade combined with nonsupine positioning in macular hole surgery for pseudophakic eyes. Retina. 2017;37(9):1750\u20136.","journal-title":"Retina"},{"issue":"1","key":"908_CR6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/IAE.0000000000002340","volume":"40","author":"Y Yu","year":"2020","unstructured":"Yu Y, Liang X, Wang Z, et al. Internal limiting membrane peeling and air tamponade for stage III and stage IV idiopathic macular hole. Retina. 2020;40(1):66\u201374.","journal-title":"Retina"},{"issue":"1","key":"908_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ophtha.2010.04.040","volume":"118","author":"R Tadayoni","year":"2011","unstructured":"Tadayoni R, Vicaut E, Devin F, et al. A randomized controlled trial of alleviated positioning after small macular hole surgery. Ophthalmology. 2011;118(1):150\u20135.","journal-title":"Ophthalmology"},{"issue":"7","key":"908_CR8","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1001\/jamaophthalmol.2020.0987","volume":"138","author":"S Pasu","year":"2020","unstructured":"Pasu S, Bell L, Zenasni Z, et al. Facedown positioning following surgery for large full-thickness macular hole: a multicenter randomized clinical trial. JAMA Ophthalmol. 2020;138(7):725.","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"908_CR9","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1016\/j.ophtha.2013.07.042","volume":"120","author":"JS Duker","year":"2013","unstructured":"Duker JS, Kaiser PK, Binder S, et al. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013;120(12):2611\u20139.","journal-title":"Ophthalmology"},{"issue":"10","key":"908_CR10","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1016\/j.ophtha.2010.02.011","volume":"117","author":"Z Michalewska","year":"2010","unstructured":"Michalewska Z, Michalewski J, Adelman RA, Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010;117(10):2018\u201325.","journal-title":"Ophthalmology"}],"container-title":["International Journal of Retina and Vitreous"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40942-026-00908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40942-026-00908-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40942-026-00908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:50:31Z","timestamp":1786445431000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40942-026-00908-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["908"],"URL":"https:\/\/doi.org\/10.1186\/s40942-026-00908-0","relation":{},"ISSN":["2056-9920"],"issn-type":[{"value":"2056-9920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"assertion":[{"value":"5 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective study was conducted in accordance with the Declaration of Helsinki. Given its retrospective design and the use of routinely collected clinical data, oral informed consent for the reuse of their data was obtained from all patients at the preoperative consultation, in line with the participating institutions\u2019 standard practice. The study was registered under reference 2025\/0145 OB (21\/05\/2025).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable; the manuscript contains no data relating to an identifiable individual.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work the authors used Claude (Anthropic) to assist with statistical analysis, drafting and language refinement. The authors reviewed and edited all content and take full responsibility for it.","order":3,"name":"Ethics","label":"Use of generative AI and AI-assisted technologies","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"106"}}