{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:05:51Z","timestamp":1784739951607,"version":"3.55.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardio-Oncology"],"DOI":"10.1186\/s40959-025-00361-2","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:32:55Z","timestamp":1751524375000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dynamic cardiac changes in low cardiovascular risk patients with triple negative breast cancer treated with chemo-immunotherapy"],"prefix":"10.1186","volume":"11","author":[{"given":"Jean Philippe","family":"Nesseler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina D.","family":"Silos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Peony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asneh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Belen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell R.","family":"Kamrava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Shiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Ramin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana P.","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn M.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"361_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"361_CR2","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-06-3045","volume":"13","author":"R Dent","year":"2007","unstructured":"Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res Off J Am Assoc Cancer Res. 2007;13:4429\u201334.","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"361_CR3","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1056\/NEJMoa1910549","volume":"382","author":"P Schmid","year":"2020","unstructured":"Schmid P, Cortes J, Pusztai L, McArthur H, K\u00fcmmel S, Bergh J, et al. Pembrolizumab for early Triple-Negative breast Cancer. N Engl J Med. 2020;382:810\u201321.","journal-title":"N Engl J Med"},{"key":"361_CR4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1056\/NEJMoa2112651","volume":"386","author":"P Schmid","year":"2022","unstructured":"Schmid P, Cortes J, Dent R, Pusztai L, McArthur H, K\u00fcmmel S, et al. Event-free survival with pembrolizumab in early Triple-Negative breast Cancer. N Engl J Med. 2022;386:556\u201367.","journal-title":"N Engl J Med"},{"key":"361_CR5","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1002\/cncr.11407","volume":"97","author":"SM Swain","year":"2003","unstructured":"Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer. 2003;97:2869\u201379.","journal-title":"Cancer"},{"key":"361_CR6","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.jacc.2018.02.037","volume":"71","author":"SS Mahmood","year":"2018","unstructured":"Mahmood SS, Fradley MG, Cohen JV, Nohria A, Reynolds KL, Heinzerling LM, et al. Myocarditis in patients treated with immune checkpoint inhibitors. J Am Coll Cardiol. 2018;71:1755\u201364.","journal-title":"J Am Coll Cardiol"},{"key":"361_CR7","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1001\/jamaoncol.2024.3065","volume":"10","author":"DL Nielsen","year":"2024","unstructured":"Nielsen DL, Juhl CB, Nielsen OH, Chen IM, Herrmann J. Immune checkpoint Inhibitor-Induced cardiotoxicity: A systematic review and Meta-Analysis. JAMA Oncol. 2024;10:1390\u20139.","journal-title":"JAMA Oncol"},{"key":"361_CR8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1684\/ejd.2021.4009","volume":"31","author":"C Scard","year":"2021","unstructured":"Scard C, Nguyen J-M, Varey E, Moustaghfir I, Khammari A, Dreno B. Cardiac adverse events associated with anti-PD-1 therapy in patients treated for advanced melanoma: relevance of dosing troponin T levels. Eur J Dermatol EJD. 2021;31:205\u201312.","journal-title":"Eur J Dermatol EJD"},{"key":"361_CR9","doi-asserted-by":"publisher","first-page":"1006860","DOI":"10.3389\/fimmu.2022.1006860","volume":"13","author":"M Liu","year":"2022","unstructured":"Liu M, Cheng X, Ni R, Zheng B, Huang S, Yang J. Cardiotoxicity of immune checkpoint inhibitors: A frequency network meta-analysis. Front Immunol. 2022;13:1006860.","journal-title":"Front Immunol"},{"key":"361_CR10","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1001\/jamaoncol.2018.3923","volume":"4","author":"DY Wang","year":"2018","unstructured":"Wang DY, Salem J-E, Cohen JV, Chandra S, Menzer C, Ye F, et al. Fatal toxic effects associated with immune checkpoint inhibitors: A systematic review and Meta-analysis. JAMA Oncol. 2018;4:1721\u20138.","journal-title":"JAMA Oncol"},{"key":"361_CR11","doi-asserted-by":"publisher","first-page":"e447","DOI":"10.1016\/S1470-2045(18)30457-1","volume":"19","author":"AR Lyon","year":"2018","unstructured":"Lyon AR, Yousaf N, Battisti NML, Moslehi J, Larkin J. Immune checkpoint inhibitors and cardiovascular toxicity. Lancet Oncol. 2018;19:e447\u201358.","journal-title":"Lancet Oncol"},{"key":"361_CR12","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.jaccao.2022.11.011","volume":"4","author":"GA Suero-Abreu","year":"2022","unstructured":"Suero-Abreu GA, Zanni MV, Neilan TG. Atherosclerosis with immune checkpoint inhibitor therapy: evidence, diagnosis, and management: JACC: cardiooncology State-of-the-Art review. JACC CardioOncology. 2022;4:598\u2013615.","journal-title":"JACC CardioOncology"},{"key":"361_CR13","doi-asserted-by":"publisher","first-page":"101478","DOI":"10.1016\/j.cpcardiol.2022.101478","volume":"48","author":"W Song","year":"2023","unstructured":"Song W, Zheng Y, Dong M, Zhong L, Bazoukis G, Perone F, et al. Electrocardiographic features of immune checkpoint Inhibitor-Associated myocarditis. Curr Probl Cardiol. 2023;48:101478.","journal-title":"Curr Probl Cardiol"},{"key":"361_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jaccao.2021.06.007","volume":"3","author":"C Bergom","year":"2021","unstructured":"Bergom C, Bradley JA, Ng AK, Samson P, Robinson C, Lopez-Mattei J, et al. Past, present, and future of Radiation-Induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC CardioOncology. 2021;3:343\u201359.","journal-title":"JACC CardioOncology"},{"key":"361_CR15","doi-asserted-by":"publisher","first-page":"5724","DOI":"10.3390\/cancers14235724","volume":"14","author":"MK Honaryar","year":"2022","unstructured":"Honaryar MK, Allodji R, Ferri\u00e8res J, Panh L, Locquet M, Jimenez G, et al. Early coronary artery calcification progression over two years in breast Cancer patients treated with radiation therapy: association with cardiac exposure (BACCARAT Study). Cancers. 2022;14:5724.","journal-title":"Cancers"},{"key":"361_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13014-019-1242-z","volume":"14","author":"A-K Wennstig","year":"2019","unstructured":"Wennstig A-K, Garmo H, Isacsson U, Gagliardi G, Rintel\u00e4 N, Lagerqvist B, et al. The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors. Radiat Oncol Lond Engl. 2019;14:40.","journal-title":"Radiat Oncol Lond Engl"},{"key":"361_CR17","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.ijrobp.2021.03.004","volume":"110","author":"VAB van den Bogaard","year":"2021","unstructured":"van den Bogaard VAB, Spoor DS, van der Schaaf A, van Dijk LV, Schuit E, Sijtsema NM, et al. The importance of radiation dose to the atherosclerotic plaque in the left anterior descending coronary artery for radiation-Induced cardiac toxicity of breast Cancer patients?? Int J Radiat Oncol Biol Phys. 2021;110:1350\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"361_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijrobp.2022.04.019","volume":"114","author":"AH Zureick","year":"2022","unstructured":"Zureick AH, Grzywacz VP, Almahariq MF, Silverman BR, Vayntraub A, Chen PY, et al. Dose to the left anterior descending artery correlates with cardiac events after irradiation for breast Cancer. Int J Radiat Oncol Biol Phys. 2022;114:130\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"361_CR19","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","volume":"15","author":"AS Agatston","year":"1990","unstructured":"Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827\u201332.","journal-title":"J Am Coll Cardiol"},{"key":"361_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","volume":"79","author":"M Feng","year":"2011","unstructured":"Feng M, Moran JM, Koelling T, Chughtai A, Chan JL, Freedman L, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2011;79:10\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"361_CR21","unstructured":"Common Terminology. Criteria for Adverse Events (CTCAE). 2017."},{"key":"361_CR22","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jacc.2008.12.014","volume":"53","author":"PM Rautaharju","year":"2009","unstructured":"Rautaharju PM, Surawicz B, Gettes LS, Bailey JJ, Childers R, Deal BJ, et al. AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American heart association electrocardiography and arrhythmias committee, Council on clinical cardiology; the American college of cardiology foundation; and the heart rhythm society. Endorsed by the international society.for computerized electrocardiology. J Am Coll Cardiol. 2009;53:982\u201391.","journal-title":"J Am Coll Cardiol"},{"key":"361_CR23","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/0735-1097(92)90376-X","volume":"20","author":"TJ Molloy","year":"1992","unstructured":"Molloy TJ, Okin PM, Devereux RB, Kligfield P. Electrocardiographic detection of left ventricular hypertrophy by the simple QRS voltage-duration product. J Am Coll Cardiol. 1992;20:1180\u20136.","journal-title":"J Am Coll Cardiol"},{"key":"361_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0002-8703(49)90562-1","volume":"37","author":"M Sokolow","year":"1949","unstructured":"Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J. 1949;37:161\u201386.","journal-title":"Am Heart J"},{"key":"361_CR25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1542-474X.1997.tb00325.x","volume":"2","author":"HC Bazett","year":"1997","unstructured":"Bazett HC. An analysis of the Time-Relations of electrocardiograms. Ann Noninvasive Electrocardiol. 1997;2:177\u201394.","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"361_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","volume":"29","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 2016;29:277\u2013314.","journal-title":"J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr"},{"key":"361_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1200\/JCO.1991.9.1.191","volume":"9","author":"JJ Shuster","year":"1991","unstructured":"Shuster JJ. Median follow-up in clinical trials. J Clin Oncol Off J Am Soc Clin Oncol. 1991;9:191\u20132.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"361_CR28","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496\u2013509.","journal-title":"J Am Stat Assoc"},{"key":"361_CR29","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1161\/CIRCULATIONAHA.121.055816","volume":"144","author":"JR Power","year":"2021","unstructured":"Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, et al. Electrocardiographic manifestations of immune checkpoint inhibitor myocarditis. Circulation. 2021;144:1521\u20133.","journal-title":"Circulation"},{"key":"361_CR30","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1634\/theoncologist.2018-0130","volume":"23","author":"S Ganatra","year":"2018","unstructured":"Ganatra S, Neilan TG. Immune checkpoint Inhibitor-Associated myocarditis. Oncologist. 2018;23:879\u201386.","journal-title":"Oncologist"},{"key":"361_CR31","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3390\/jcm9072060","volume":"9","author":"J Pohl","year":"2020","unstructured":"Pohl J, Mincu R-I, Mrotzek SM, Hinrichs L, Michel L, Livingstone E, et al. ECG changes in melanoma patients undergoing Cancer Therapy-Data from the ECoR registry. J Clin Med. 2020;9:2060.","journal-title":"J Clin Med"},{"key":"361_CR32","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1161\/01.CIR.84.3.1136","volume":"84","author":"AJ Moss","year":"1991","unstructured":"Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J, et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation. 1991;84:1136\u201344.","journal-title":"Circulation"},{"key":"361_CR33","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"AR Lyon","year":"2022","unstructured":"Lyon AR, L\u00f3pez-Fern\u00e1ndez T, Couch LS, Asteggiano R, Aznar MC, Bergler-Klein J, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international Cardio-Oncology society (IC-OS). Eur Heart J. 2022;43:4229\u2013361.","journal-title":"Eur Heart J"},{"key":"361_CR34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1001\/jama.289.2.194","volume":"289","author":"MM Redfield","year":"2003","unstructured":"Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194\u2013202.","journal-title":"JAMA"},{"key":"361_CR35","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0735-1097(92)90138-D","volume":"20","author":"MF Stoddard","year":"1992","unstructured":"Stoddard MF, Seeger J, Liddell NE, Hadley TJ, Sullivan DM, Kupersmith J. Prolongation of isovolumetric relaxation time as assessed by doppler echocardiography predicts doxorubicin-induced systolic dysfunction in humans. J Am Coll Cardiol. 1992;20:62\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"361_CR36","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1161\/CIRCULATIONAHA.105.601005","volume":"114","author":"JE M\u00f8ller","year":"2006","unstructured":"M\u00f8ller JE, Pellikka PA, Hillis GS, Oh JK. Prognostic importance of diastolic function and filling pressure in patients with acute myocardial infarction. Circulation. 2006;114:438\u201344.","journal-title":"Circulation"},{"key":"361_CR37","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jcmg.2019.07.018","volume":"13","author":"JN Upshaw","year":"2020","unstructured":"Upshaw JN, Finkelman B, Hubbard RA, Smith AM, Narayan HK, Arndt L, et al. Comprehensive assessment of changes in left ventricular diastolic function with contemporary breast Cancer therapy. JACC Cardiovasc Imaging. 2020;13:198\u2013210.","journal-title":"JACC Cardiovasc Imaging"},{"key":"361_CR38","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jjcc.2019.02.001","volume":"74","author":"DY Kim","year":"2019","unstructured":"Kim DY, Youn J-C, Park M-S, Lee S, Choi S-W, Ryu K-H, et al. Cardiovascular outcome of breast cancer patients with concomitant radiotherapy and chemotherapy: A 10-year multicenter cohort study. J Cardiol. 2019;74:175\u201381.","journal-title":"J Cardiol"},{"key":"361_CR39","doi-asserted-by":"publisher","first-page":"101384","DOI":"10.1016\/j.adro.2023.101384","volume":"9","author":"T Tison","year":"2024","unstructured":"Tison T, Loap P, Arnaud E, Cao K, Bringer S, Kissel M, et al. Tolerance of concurrent adjuvant radiation therapy and pembrolizumab for triple negative breast cancer: real life experience. Adv Radiat Oncol. 2024;9:101384.","journal-title":"Adv Radiat Oncol"},{"key":"361_CR40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/jamaoncol.2023.5033","volume":"10","author":"P Sharma","year":"2024","unstructured":"Sharma P, Stecklein SR, Yoder R, Staley JM, Schwensen K, O\u2019Dea A, et al. Clinical and biomarker findings of neoadjuvant pembrolizumab and carboplatin plus docetaxel in Triple-Negative breast cancer: NeoPACT phase 2 clinical trial. JAMA Oncol. 2024;10:227\u201335.","journal-title":"JAMA Oncol"},{"key":"361_CR41","unstructured":"Pembrolizumab versus Observation in Patients with Early Stage Triple-Negative. Breast Cancer who had a Pathologic Complete Response after Chemotherapy plus Pembrolizumab, OptimICE-PCR Trial - NCI [Internet]. 2016 [cited 2024 Oct 11]. Available from: https:\/\/www.cancer.gov\/about-cancer\/treatment\/clinical-trials\/search\/v?id=NCI-2022-07859"},{"key":"361_CR42","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1161\/CIRCULATIONAHA.118.037934","volume":"140","author":"P Garcia-Pavia","year":"2019","unstructured":"Garcia-Pavia P, Kim Y, Restrepo-Cordoba MA, Lunde IG, Wakimoto H, Smith AM, et al. Genetic variants associated with Cancer Therapy-Induced cardiomyopathy. Circulation. 2019;140:31\u201341.","journal-title":"Circulation"},{"key":"361_CR43","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Br\u00f8nnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987\u201398.","journal-title":"N Engl J Med"},{"key":"361_CR44","first-page":"175","volume":"14","author":"HB Stowe","year":"2022","unstructured":"Stowe HB, Andruska ND, Reynoso F, Thomas M, Bergom C. Heart sparing radiotherapy techniques in breast cancer: A focus on deep inspiration breath hold. Breast Cancer Dove Med Press. 2022;14:175\u201386.","journal-title":"Breast Cancer Dove Med Press"},{"key":"361_CR45","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.prro.2020.01.001","volume":"10","author":"NK Gerber","year":"2020","unstructured":"Gerber NK, Yan SX, Levinson BA, Perez CA, Das IJ, Maisonet OG, et al. A prospective trial to compare deep inspiratory breath hold with prone breast irradiation. Pract Radiat Oncol. 2020;10:330\u20138.","journal-title":"Pract Radiat Oncol"},{"key":"361_CR46","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/acm2.12382","volume":"19","author":"AS Saini","year":"2018","unstructured":"Saini AS, Hwang CS, Biagioli MC, Das IJ. Evaluation of sparing organs at risk (OARs) in left-breast irradiation in the supine and prone positions and with deep inspiration breath-hold. J Appl Clin Med Phys. 2018;19:195\u2013204.","journal-title":"J Appl Clin Med Phys"},{"key":"361_CR47","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","volume":"390","author":"CE Coles","year":"2017","unstructured":"Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, et al. Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. Lancet Lond Engl. 2017;390:1048\u201360.","journal-title":"Lancet Lond Engl"},{"key":"361_CR48","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1200\/JCO.20.00650","volume":"38","author":"I Meattini","year":"2020","unstructured":"Meattini I, Marrazzo L, Saieva C, Desideri I, Scotti V, Simontacchi G, et al. Accelerated Partial-Breast irradiation compared with Whole-Breast irradiation for early breast cancer: Long-Term results of the randomized phase III APBI-IMRT-Florence trial. J Clin Oncol Off J Am Soc Clin Oncol. 2020;38:4175\u201383.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"361_CR49","doi-asserted-by":"publisher","first-page":"24","DOI":"10.14338\/IJPT-20-00026.1","volume":"7","author":"D Mondal","year":"2021","unstructured":"Mondal D, Jhawar SR, Millevoi R, Haffty BG, Parikh RR. Proton versus photon Breath-Hold radiation for Left-Sided breast Cancer after breast-Conserving surgery: A dosimetric comparison. Int J Part Ther. 2021;7:24\u201333.","journal-title":"Int J Part Ther"},{"key":"361_CR50","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s13014-020-01671-8","volume":"15","author":"G Cartechini","year":"2020","unstructured":"Cartechini G, Fracchiolla F, Menegotti L, Scifoni E, La Tessa C, Schwarz M, et al. Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy. Radiat Oncol Lond Engl. 2020;15:228.","journal-title":"Radiat Oncol Lond Engl"},{"key":"361_CR51","doi-asserted-by":"publisher","first-page":"100901","DOI":"10.1016\/j.adro.2022.100901","volume":"7","author":"AE Garda","year":"2022","unstructured":"Garda AE, Hunzeker AE, Michel AK, Fattahi S, Shiraishi S, Remmes NB, et al. Intensity modulated proton therapy for bilateral breast or chest wall and comprehensive nodal irradiation for synchronous bilateral breast cancer: initial clinical experience and dosimetric comparison. Adv Radiat Oncol. 2022;7:100901.","journal-title":"Adv Radiat Oncol"},{"key":"361_CR52","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.radonc.2020.04.022","volume":"148","author":"S Quirk","year":"2020","unstructured":"Quirk S, Grendarova P, Phan T, Conroy L, Burke B, Long K, et al. A retrospective analysis to demonstrate achievable dosimetry for the left anterior descending artery in left-sided breast cancer patients treated with radiotherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2020;148:167\u201373.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"361_CR53","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1001\/jamaoncol.2020.6332","volume":"7","author":"KM Atkins","year":"2021","unstructured":"Atkins KM, Chaunzwa TL, Lamba N, Bitterman DS, Rawal B, Bredfeldt J, et al. Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with Non-Small cell lung Cancer. JAMA Oncol. 2021;7:206\u201319.","journal-title":"JAMA Oncol"},{"key":"361_CR54","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13014-016-0627-5","volume":"11","author":"S Jacob","year":"2016","unstructured":"Jacob S, Pathak A, Franck D, Latorzeff I, Jimenez G, Fondard O, et al. Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study. Radiat Oncol Lond Engl. 2016;11:54.","journal-title":"Radiat Oncol Lond Engl"},{"key":"361_CR55","doi-asserted-by":"publisher","first-page":"e230569","DOI":"10.1001\/jamanetworkopen.2023.0569","volume":"6","author":"EG Kabor\u00e9","year":"2023","unstructured":"Kabor\u00e9 EG, Macdonald C, Kabor\u00e9 A, Didier R, Arveux P, Meda N, et al. Risk prediction models for cardiotoxicity of chemotherapy among patients with breast cancer: A systematic review. JAMA Netw Open. 2023;6:e230569.","journal-title":"JAMA Netw Open"}],"container-title":["Cardio-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-025-00361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40959-025-00361-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-025-00361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T08:03:04Z","timestamp":1751529784000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiooncologyjournal.biomedcentral.com\/articles\/10.1186\/s40959-025-00361-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["361"],"URL":"https:\/\/doi.org\/10.1186\/s40959-025-00361-2","relation":{},"ISSN":["2057-3804"],"issn-type":[{"value":"2057-3804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"11 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study obtained ethical approval from the Cedars-Sinai Medical Center Institutional Review Board with a waiver of informed consent due to minimal risk nature (STUDY00003061).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"62"}}