{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:20:07Z","timestamp":1785450007585,"version":"3.56.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202248"],"award-info":[{"award-number":["82202248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2023M732461"],"award-info":[{"award-number":["2023M732461"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"crossref","award":["23NSFSC4589"],"award-info":[{"award-number":["23NSFSC4589"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0521802"],"award-info":[{"award-number":["2024ZD0521802"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardio-Oncology"],"DOI":"10.1186\/s40959-025-00377-8","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T12:21:42Z","timestamp":1759407702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An innovative hybrid imaging protocol for whole-body 18F-FDG-PET\/MRI in cardio-oncology: a proof-of-concept study"],"prefix":"10.1186","volume":"11","author":[{"given":"Yaqiong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"377_CR1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41571-023-00802-w","volume":"20","author":"MJ Ehrhardt","year":"2023","unstructured":"Ehrhardt MJ, Krull KR, Bhakta N, Liu Q, Yasui Y, Robison LL, et al. Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century. Nat Rev Clin Oncol. 2023;20:678\u201396.","journal-title":"Nat Rev Clin Oncol"},{"key":"377_CR2","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/eurheartj\/ehy026","volume":"39","author":"J Faber","year":"2018","unstructured":"Faber J, Wingerter A, Neu MA, Henninger N, Eckerle S, M\u00fcnzel T, et al. Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J. 2018;39:1555\u201362.","journal-title":"Eur Heart J"},{"key":"377_CR3","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0140-6736(19)31674-5","volume":"394","author":"H Strongman","year":"2019","unstructured":"Strongman H, Gadd S, Matthews A, Mansfield KE, Stanway S, Lyon AR, et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394:1041\u201354.","journal-title":"Lancet"},{"key":"377_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1080\/17474086.2021.2003704","volume":"14","author":"M Camilli","year":"2021","unstructured":"Camilli M, La Vecchia G, Lillo R, Iannaccone G, Lamendola P, Montone RA, et al. Cardiovascular involvement in patients affected by multiple myeloma: a comprehensive review of recent advances. Expert Rev Hematol. 2021;14:1115\u201328.","journal-title":"Expert Rev Hematol"},{"key":"377_CR5","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"AR Lyon","year":"2022","unstructured":"Lyon AR, L\u00f3pez-Fern\u00e1ndez T, Couch LS, Asteggiano R, Aznar MC, Bergler-Klein J, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international Cardio-Oncology society (IC-OS). Eur Heart J. 2022;43:4229\u2013361.","journal-title":"Eur Heart J"},{"key":"377_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.annonc.2019.10.023","volume":"31","author":"G Curigliano","year":"2020","unstructured":"Curigliano G, Lenihan D, Fradley M, Ganatra S, Barac A, Blaes A, et al. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31:171\u201390.","journal-title":"Ann Oncol"},{"key":"377_CR7","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/ejhf.1326","volume":"20","author":"JF Nauta","year":"2018","unstructured":"Nauta JF, Jin X, Hummel YM, Voors AA. Markers of left ventricular systolic dysfunction when left ventricular ejection fraction is normal. Eur J Heart Fail. 2018;20:1636\u20138.","journal-title":"Eur J Heart Fail"},{"key":"377_CR8","doi-asserted-by":"publisher","first-page":"101721","DOI":"10.1016\/j.cpcardiol.2023.101721","volume":"48","author":"J Clark","year":"2023","unstructured":"Clark J, Ionescu A, Chahal CAA, Bhattacharyya S, Lloyd G, Galanti K, et al. Interchangeability in left ventricular ejection fraction measured by echocardiography and cardiovascular magnetic resonance: not a perfect match in the real world. Curr Probl Cardiol. 2023;48:101721.","journal-title":"Curr Probl Cardiol"},{"key":"377_CR9","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.echo.2012.08.007","volume":"25","author":"N Risum","year":"2012","unstructured":"Risum N, Ali S, Olsen NT, Jons C, Khouri MG, Lauridsen TK, et al. Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults. J Am Soc Echocardiogr. 2012;25:1195\u2013203.","journal-title":"J Am Soc Echocardiogr"},{"key":"377_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jcmg.2017.01.027","volume":"11","author":"O Mirea","year":"2018","unstructured":"Mirea O, Pagourelias ED, Duchenne J, Bogaert J, Thomas JD, Badano LP, et al. Variability and reproducibility of segmental longitudinal strain measurement: A report from the EACVI-ASE strain standardization task force. JACC Cardiovasc Imaging. 2018;11:15\u201324.","journal-title":"JACC Cardiovasc Imaging"},{"key":"377_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jaccao.2021.04.011","volume":"3","author":"R O\u2019Quinn","year":"2021","unstructured":"O\u2019Quinn R, Ferrari VA, Daly R, Hundley G, Baldassarre LA, Han Y, et al. Cardiac magnetic resonance in Cardio-Oncology: advantages, importance of expediency, and considerations to navigate Pre-Authorization. JACC CardioOncol. 2021;3:191\u2013200.","journal-title":"JACC CardioOncol"},{"key":"377_CR12","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1093\/eurheartj\/ehad510","volume":"44","author":"DC Benz","year":"2023","unstructured":"Benz DC, Gr\u00e4ni C, Antiochos P, Heydari B, Gissler MC, Ge Y, et al. Cardiac magnetic resonance biomarkers as surrogate endpoints in cardiovascular trials for myocardial diseases. Eur Heart J. 2023;44:4738\u201347.","journal-title":"Eur Heart J"},{"key":"377_CR13","doi-asserted-by":"crossref","unstructured":"Smiseth OA, Rider O, Cvijic M, Valkovi\u010d L, Remme EW, Voigt JU. Myocardial strain imaging: theory, current practice, and the future. JACC Cardiovasc Imaging.; 2024.","DOI":"10.1016\/j.jcmg.2024.07.011"},{"key":"377_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1053\/j.semnuclmed.2021.11.012","volume":"52","author":"R Seifert","year":"2022","unstructured":"Seifert R, Kersting D, Rischpler C, Opitz M, Kirchner J, Pabst KM, et al. Clinical use of PET\/MR in oncology: an update. Semin Nucl Med. 2022;52:356\u201364.","journal-title":"Semin Nucl Med"},{"key":"377_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2967\/jnumed.113.123646","volume":"55","author":"M Eiber","year":"2014","unstructured":"Eiber M, Takei T, Souvatzoglou M, Mayerhoefer ME, F\u00fcrst S, Gaertner FC, et al. Performance of whole-body integrated 18F-FDG PET\/MR in comparison to PET\/CT for evaluation of malignant bone lesions. J Nucl Med. 2014;55:191\u20137.","journal-title":"J Nucl Med"},{"key":"377_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s12350-018-1356-y","volume":"26","author":"FM Bengel","year":"2019","unstructured":"Bengel FM, Ross TL. Emerging imaging targets for infiltrative cardiomyopathy: inflammation and fibrosis. J Nucl Cardiol. 2019;26:208\u201316.","journal-title":"J Nucl Cardiol"},{"key":"377_CR17","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s10741-020-10063-9","volume":"26","author":"I Fabiani","year":"2021","unstructured":"Fabiani I, Aimo A, Grigoratos C, Castiglione V, Gentile F, Saccaro LF, et al. Oxidative stress and inflammation: determinants of anthracycline cardiotoxicity and possible therapeutic targets. Heart Fail Rev. 2021;26:881\u201390.","journal-title":"Heart Fail Rev"},{"key":"377_CR18","doi-asserted-by":"publisher","first-page":"s29","DOI":"10.2967\/jnumed.122.264868","volume":"64","author":"D Kersting","year":"2023","unstructured":"Kersting D, Mavroeidi IA, Settelmeier S, Seifert R, Schuler M, Herrmann K, et al. Molecular imaging biomarkers in cardiooncology: A view on established technologies and future perspectives. J Nucl Med. 2023;64:s29\u201338.","journal-title":"J Nucl Med"},{"key":"377_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s11886-022-01641-4","volume":"24","author":"JM Kelly","year":"2022","unstructured":"Kelly JM, Babich JW. PET tracers for imaging cardiac function in Cardio-oncology. Curr Cardiol Rep. 2022;24:247\u201360.","journal-title":"Curr Cardiol Rep"},{"key":"377_CR20","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","volume":"42","author":"R Boellaard","year":"2015","unstructured":"Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, et al. FDG PET\/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328\u201354.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"377_CR21","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1182\/blood-2016-01-631200","volume":"127","author":"P Sonneveld","year":"2016","unstructured":"Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, et al. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the international myeloma working group. Blood. 2016;127:2955\u201362.","journal-title":"Blood"},{"key":"377_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s11604-021-01097-6","volume":"39","author":"R Minamimoto","year":"2021","unstructured":"Minamimoto R. Series of myocardial FDG uptake requiring considerations of myocardial abnormalities in FDG-PET\/CT. Jpn J Radiol. 2021;39:540\u201357.","journal-title":"Jpn J Radiol"},{"key":"377_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11886-021-01529-9","volume":"23","author":"A \u0106orovi\u0107","year":"2021","unstructured":"\u0106orovi\u0107 A, Nus M, Mallat Z, Rudd JHF, Tarkin JM. PET imaging of Post-infarct myocardial inflammation. Curr Cardiol Rep. 2021;23:99.","journal-title":"Curr Cardiol Rep"},{"key":"377_CR24","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.2967\/jnumed.121.261981","volume":"62","author":"C Ozutemiz","year":"2021","unstructured":"Ozutemiz C, Koksel Y, Froelich JW, Rubin N, Bhargava M, Roukuz H, Comparison of the effect of three different dietary modifications on myocardial suppression in, et al. (18)F-FDG PET\/CT evaluation of patients for suspected cardiac sarcoidosis. J Nucl Med. 2021;62:1759\u201367.","journal-title":"J Nucl Med"},{"key":"377_CR25","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s12350-016-0522-3","volume":"23","author":"V Dilsizian","year":"2016","unstructured":"Dilsizian V, Bacharach SL, Beanlands RS, Bergmann SR, Delbeke D, Dorbala S, et al. ASNC imaging guidelines\/snmmi procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J Nucl Cardiol. 2016;23:1187\u2013226.","journal-title":"J Nucl Cardiol"},{"key":"377_CR26","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1007\/s00330-021-08388-6","volume":"32","author":"R Burns","year":"2022","unstructured":"Burns R, Mul\u00e9 S, Blanc-Durand P, Tofighi M, Belhadj K, Zerbib P, et al. Optimization of whole-body 2-[(18)F]FDG-PET\/MRI imaging protocol for the initial staging of patients with myeloma. Eur Radiol. 2022;32:3085\u201396.","journal-title":"Eur Radiol"},{"key":"377_CR27","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1007\/s12350-017-1057-y","volume":"24","author":"PL Tilkemeier","year":"2017","unstructured":"Tilkemeier PL, Bourque J, Doukky R, Sanghani R, Weinberg RL. ASNC imaging guidelines for nuclear cardiology procedures: standardized reporting of nuclear cardiology procedures. J Nucl Cardiol. 2017;24:2064\u2013128.","journal-title":"J Nucl Cardiol"},{"key":"377_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1532-429X-15-91","volume":"15","author":"CM Kramer","year":"2013","unstructured":"Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. J Cardiovasc Magn Reson. 2013;15:91.","journal-title":"J Cardiovasc Magn Reson"},{"key":"377_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1055\/a-0828-8654","volume":"191","author":"L Umutlu","year":"2019","unstructured":"Umutlu L, Beyer T, Grueneisen JS, Rischpler C, Quick HH, Veit-Haibach P, et al. Whole-Body [18F]-FDG-PET\/MRI for oncology: A consensus recommendation. Rofo. 2019;191:289\u201397.","journal-title":"Rofo"},{"key":"377_CR30","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/j.hrthm.2024.09.011","volume":"22","author":"A Devesa","year":"2025","unstructured":"Devesa A, Robson PM, Cangut B, Vazirani R, Vergani V, LaRocca G, et al. Specific locations of myocardial inflammation and fibrosis are associated with higher risk of events in cardiac sarcoidosis. Heart Rhythm. 2025;22:1606\u201314.","journal-title":"Heart Rhythm"},{"key":"377_CR31","first-page":"1049","volume":"118","author":"MLC Dourado","year":"2022","unstructured":"Dourado MLC, Dompieri LT, Leit\u00e3o GM, Mourato FA, Santos RGG, Almeida Filho PJ, et al. Chemotherapy-induced Cardiac18F-FDG uptake in patients with lymphoma: an early metabolic index of cardiotoxicity?? Arq Bras Cardiol. 2022;118:1049\u201358.","journal-title":"Arq Bras Cardiol"},{"key":"377_CR32","doi-asserted-by":"crossref","unstructured":"Haider A, Bengs S, Schade K, Wijnen WJ, Portmann A, Etter D et al. Myocardial (18)F-FDG uptake pattern for cardiovascular risk stratification in patients undergoing oncologic PET\/CT. J Clin Med. 2020;9.","DOI":"10.3390\/jcm9072279"},{"key":"377_CR33","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00259-002-1018-8","volume":"30","author":"JT Deichen","year":"2003","unstructured":"Deichen JT, Prante O, Gack M, Schmiedehausen K, Kuwert T. Uptake of [18F]fluorodeoxyglucose in human monocyte-macrophages in vitro. Eur J Nucl Med Mol Imaging. 2003;30:267\u201373.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"377_CR34","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.jcmg.2018.05.026","volume":"11","author":"JT Thackeray","year":"2018","unstructured":"Thackeray JT, Bengel FM. Molecular imaging of myocardial inflammation with positron emission tomography Post-Ischemia: A determinant of subsequent remodeling or recovery. JACC Cardiovasc Imaging. 2018;11:1340\u201355.","journal-title":"JACC Cardiovasc Imaging"},{"key":"377_CR35","doi-asserted-by":"publisher","first-page":"813883","DOI":"10.3389\/fcvm.2022.813883","volume":"9","author":"F Cadour","year":"2022","unstructured":"Cadour F, Thuny F, Sourdon J. New insights in early detection of anticancer Drug-Related cardiotoxicity using perfusion and metabolic imaging. Front Cardiovasc Med. 2022;9:813883.","journal-title":"Front Cardiovasc Med"},{"key":"377_CR36","doi-asserted-by":"crossref","unstructured":"Chung HW, Park KS, Lim I, Noh WC, Yoo YB, Nam SE et al. PET\/MRI and novel targets for breast cancer. Biomedicines. 2024;12.","DOI":"10.3390\/biomedicines12010172"},{"key":"377_CR37","doi-asserted-by":"crossref","unstructured":"Bhutani V, Varzideh F, Wilson S, Kansakar U, Jankauskas SS, Santulli G. Doxorubicin-Induced cardiotoxicity: A comprehensive update. J Cardiovasc Dev Dis. 2025;12.","DOI":"10.3390\/jcdd12060207"}],"container-title":["Cardio-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-025-00377-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40959-025-00377-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-025-00377-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T12:21:44Z","timestamp":1759407704000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiooncologyjournal.biomedcentral.com\/articles\/10.1186\/s40959-025-00377-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["377"],"URL":"https:\/\/doi.org\/10.1186\/s40959-025-00377-8","relation":{},"ISSN":["2057-3804"],"issn-type":[{"value":"2057-3804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"7 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of West China Hospital, Sichuan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}