{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:28:15Z","timestamp":1776896895225,"version":"3.51.2"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardio-Oncology"],"DOI":"10.1186\/s40959-026-00444-8","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:46:05Z","timestamp":1768041965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The ROOT-CTRCD study: exploring the relationship of oral health to cancer therapy-related cardiac dysfunction in HER2-positive breast cancer patients"],"prefix":"10.1186","volume":"12","author":[{"given":"Ahmed","family":"Basuoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Al-Baimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4993-5802","authenticated-orcid":false,"given":"Fatma","family":"AlKindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0279-4842","authenticated-orcid":false,"given":"Waleed","family":"Dawelbeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"AlHarrasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadil","family":"Al-Sharqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadiya","family":"AlKindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-1099","authenticated-orcid":false,"given":"Amany Hany Mohamed","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"issue":"9814","key":"444_CR1","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/S0140-6736(11)61625-5","volume":"379","author":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG)","year":"2012","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG). Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women. Lancet. 2012;379(9814):432\u201344. https:\/\/doi.org\/10.1016\/S0140-6736(11)61625-5.","journal-title":"Lancet"},{"key":"444_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006243.pub2","volume":"4","author":"L Moja","year":"2012","unstructured":"Moja L, Tagliabue L, Balduzzi S, Parmelli E, Pistotti V, Guarneri V, et al. Trastuzumab containing regimens for early breast cancer. Cochrane Database Syst Rev. 2012;4:CD006243. https:\/\/doi.org\/10.1002\/14651858.CD006243.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"444_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antib10010007","volume":"10","author":"J Zhao","year":"2021","unstructured":"Zhao J, Mohan N, Nussinov R, Ma B, Wu WJ. Trastuzumab blocks the receiver function of HER2 leading to the population shifts of HER2-containing homodimers and heterodimers. Antibodies (Basel). 2021;10(1):7. https:\/\/doi.org\/10.3390\/antib10010007.","journal-title":"Antibodies (Basel)"},{"issue":"5","key":"444_CR4","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.jacc.2004.03.068","volume":"44","author":"G -Minotti","year":"2004","unstructured":"-Minotti G, et al. Anthracyclines: molecular advances and Pharmacologic developments in antitumor activity and cardiotoxicity. J Am Coll Cardiol. 2004;44(5):882\u20135. https:\/\/doi.org\/10.1016\/j.jacc.2004.03.068.","journal-title":"J Am Coll Cardiol"},{"key":"444_CR5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejca.2023.02.019","volume":"185","author":"WCM Dempke","year":"2023","unstructured":"Dempke WCM, Zielinski R, Winkler C, Silberman S, Reuther S, Priebe W. Anthracycline-induced cardiotoxicity - are we about to clear this hurdle? Eur J Cancer. 2023;185:94\u2013104. https:\/\/doi.org\/10.1016\/j.ejca.2023.02.019.","journal-title":"Eur J Cancer"},{"key":"444_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10549-021-06280-x","volume":"188","author":"N Dempsey","year":"2021","unstructured":"Dempsey N, Rosenthal A, Dabas N, et al. Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies. Breast Cancer Res Treat. 2021;188:21\u201336. https:\/\/doi.org\/10.1007\/s10549-021-06280-x.","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"444_CR7","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1056\/NEJM199103213241210","volume":"324","author":"JH Doroshow","year":"1991","unstructured":"Doroshow JH. Doxorubicin-induced cardiac toxicity. N Engl J Med. 1991;324(12):843\u20135. https:\/\/doi.org\/10.1056\/NEJM199103213241210.","journal-title":"N Engl J Med"},{"issue":"8","key":"444_CR8","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1161\/CIR.0000000000000556","volume":"137","author":"LS Mehta","year":"2018","unstructured":"Mehta LS, Watson KE, Barac A, et al., et al. Cardiovascular disease and breast cancer: where these entities intersect: A scientific statement from the American heart association [published correction appears in Circulation. 2019;140(9):e543. Doi: 10.1161\/CIR.0000000000000728]. Circulation. 2018;137(8):e30\u201366. https:\/\/doi.org\/10.1161\/CIR.0000000000000556.","journal-title":"Circulation"},{"key":"444_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s40959-024-00258-6","volume":"10","author":"K Merolillo","year":"2024","unstructured":"Merolillo K, Solari MIG, Cohen TP, et al. Association of anthropometric variables with therapy-induced cardiotoxicity in women with breast cancer: a pilot study for a randomized clinical trial. Cardio-Oncology. 2024;10:57. https:\/\/doi.org\/10.1186\/s40959-024-00258-6.","journal-title":"Cardio-Oncology"},{"issue":"7","key":"444_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju098","volume":"106","author":"D Schmid","year":"2014","unstructured":"Schmid D, Leitzmann MF. Television viewing and time spent sedentary in relation to cancer risk: a meta-analysis. J Natl Cancer Inst. 2014;106(7):dju098. https:\/\/doi.org\/10.1093\/jnci\/dju098.","journal-title":"J Natl Cancer Inst"},{"key":"444_CR11","doi-asserted-by":"publisher","unstructured":"-L\u00e8lita, Santos. The impact of nutrition and lifestyle modification on health. Eur J Intern Med. 2022;97. https:\/\/doi.org\/10.1016\/j.ejim.2021.09.020. Pages 18\u201325, ISSN 0953\u20136205.","DOI":"10.1016\/j.ejim.2021.09.020"},{"key":"444_CR12","doi-asserted-by":"crossref","unstructured":"-Kamel AHM, Basuoni A, Salem ZA, AbuBakr N. The impact of oral health status on COVID-19 severity, recovery period and C-reactive protein values. Br Dent J. 2021.","DOI":"10.1038\/s41415-021-2656-1"},{"issue":"3","key":"444_CR13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jcpe.13189","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D\u2019Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268\u201388. https:\/\/doi.org\/10.1111\/jcpe.13189.","journal-title":"J Clin Periodontol"},{"key":"444_CR14","doi-asserted-by":"publisher","unstructured":"-Lyon AR, L\u00f3pez-Fern\u00e1ndez T, Couch LS et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS) [published correction appears in Eur Heart J. 2023;44(18):1621. https:\/\/doi.org\/10.1093\/eurheartj\/ehad196.]. Eur Heart J. 2022;43(41):4229\u20134361. DOI:10.1093\/eurheartj\/ehac244.","DOI":"10.1093\/eurheartj\/ehad196.]"},{"key":"444_CR15","volume-title":"Oral Health Surveys: Basic Methods","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. Oral Health Surveys: Basic Methods. 5th ed. World Health Organization; 2013.","edition":"5th ed"},{"issue":"1","key":"444_CR16","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1002\/JPER.18-0006","volume":"89","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(1):S159\u201372. https:\/\/doi.org\/10.1002\/JPER.18-0006.","journal-title":"J Periodontol"},{"issue":"1","key":"444_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.5051\/jpis.2201060053","volume":"53","author":"K Erta\u015f","year":"2023","unstructured":"Erta\u015f K, Pence I, Cesmeli MS, Ay ZY. Determination of the stage and grade of periodontitis according to the current classification of periodontal and peri-implant diseases and conditions (2018) using machine learning algorithms. J Periodontal Implant Sci. 2023;53(1):38\u201353. https:\/\/doi.org\/10.5051\/jpis.2201060053.","journal-title":"J Periodontal Implant Sci"},{"issue":"1","key":"444_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-11-3","volume":"11","author":"D Ziebolz","year":"2011","unstructured":"Ziebolz D, Szabadi I, Rinke S, Hornecker E, Mausberg RF. Initial periodontal screening and radiographic findings\u2013a comparison of two methods to evaluate the periodontal situation. BMC Oral Health. 2011;11(1):3. https:\/\/doi.org\/10.1186\/1472-6831-11-3.","journal-title":"BMC Oral Health"},{"key":"444_CR19","doi-asserted-by":"publisher","first-page":"8859","DOI":"10.1007\/s12652-021-03634-7","volume":"14","author":"MSA Vigil","year":"2023","unstructured":"Vigil MSA, Bharathi VS. Classification of periodontitis stages in mandibular area from dental panoramic radiograph using adaptive center line-distance based image processing approach. J Ambient Intell Human Comput. 2023;14:8859\u201369. https:\/\/doi.org\/10.1007\/s12652-021-03634-7.","journal-title":"J Ambient Intell Human Comput"},{"key":"444_CR20","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1002\/ejhf.1920","volume":"22","author":"AR -Lyon","year":"2020","unstructured":"-Lyon AR, Dent S, Stanway S, Earl H, Brezden-Masley C, Cohen-Solal A, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology study group of the heart failure association of the European society. Eur J Heart Fail. 2020;22:1945\u201360. https:\/\/doi.org\/10.1002\/ejhf.1920.","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"444_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s40959-020-00081-9","volume":"6","author":"S Sardesai","year":"2020","unstructured":"Sardesai S, Sukumar J, Kassem M, et al. Clinical impact of interruption in adjuvant trastuzumab therapy in patients with operable HER-2 positive breast cancer. Cardio-Oncology. 2020;6(1):26. https:\/\/doi.org\/10.1186\/s40959-020-00081-9.","journal-title":"Cardio-Oncology"},{"issue":"40","key":"444_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta24400","volume":"24","author":"H Earl","year":"2020","unstructured":"Earl H, Hiller L, Vallier AL, et al. Six versus 12 months\u2019 adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT. Health Technol Assess. 2020;24(40):1\u2013190. https:\/\/doi.org\/10.3310\/hta24400.","journal-title":"Health Technol Assess"},{"issue":"8","key":"444_CR23","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S1470-2045(13)70225-0","volume":"14","author":"X Pivot","year":"2013","unstructured":"Pivot X, Romieu G, Debled M, Pierga J-Y, Kerbrat P, Bachelot T, et al. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial. Lancet Oncol. 2013;14(8):741\u20138. https:\/\/doi.org\/10.1016\/S1470-2045(13)70225-0.","journal-title":"Lancet Oncol"},{"issue":"9","key":"444_CR24","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1001\/jamaoncol.2018.1380.","volume":"4","author":"H Joensuu","year":"2018","unstructured":"Joensuu H, Fraser J, Wildiers H, Huovinen R, Auvinen P, Utriainen M, et al. Effect of adjuvant trastuzumab for a duration of 9 weeks vs 1 year with concomitant chemotherapy for early human epidermal growth factor receptor 2\u2013positive breast cancer: the SOLD randomized clinical trial. JAMA Oncol. 2018;4(9):1199\u2013206. https:\/\/doi.org\/10.1001\/jamaoncol.2018.1380.","journal-title":"JAMA Oncol"},{"issue":"44","key":"444_CR25","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005195","volume":"95","author":"Z Jawa","year":"2016","unstructured":"Jawa Z, Perez RM, Garlie L, Singh M, Qamar R, Khandheria BK, et al. Risk factors of trastuzumab-induced cardiotoxicity in breast cancer: a meta-analysis. Medicine (Baltimore). 2016;95(44):e5195. https:\/\/doi.org\/10.1097\/MD.0000000000005195.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"444_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00520-017-3829-y","volume":"26","author":"CHL Hong","year":"2018","unstructured":"Hong CHL, Hu S, Haverman T, et al. A systematic review of dental disease management in cancer patients. Support Care Cancer. 2018;26(1):155\u201374. https:\/\/doi.org\/10.1007\/s00520-017-3829-y.","journal-title":"Support Care Cancer"},{"key":"444_CR27","doi-asserted-by":"publisher","unstructured":"Kotronia E, Brown H, Papacosta AO, et al. Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA. Sci Rep. 2021(1). https:\/\/doi.org\/10.1038\/s41598-021-95865-z.","DOI":"10.1038\/s41598-021-95865-z"},{"issue":"2","key":"444_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/HJH.0000000000003022","volume":"40","author":"J Kim","year":"2022","unstructured":"Kim J, Kim HJ, Jeon J, Song TJ. Association between oral health and cardiovascular outcomes in patients with hypertension: a nationwide cohort study. J Hypertens. 2022;40(2):374\u201381. https:\/\/doi.org\/10.1097\/HJH.0000000000003022.","journal-title":"J Hypertens"},{"key":"444_CR29","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211052507","author":"O Deraz","year":"2022","unstructured":"Deraz O, Rang\u00e9 H, Boutouyrie P, et al. Oral condition and incident coronary heart disease: a clustering analysis. J Dent Res. 2022. https:\/\/doi.org\/10.1177\/00220345211052507.","journal-title":"J Dent Res"},{"key":"444_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13584","author":"KS Kim","year":"2022","unstructured":"Kim KS, Kim T, Kang SH, Lee JR, Lee HJ, Lee H. Effect of dental screening on cardiovascular risk: a nationwide cohort study. J Clin Periodontol. 2022. https:\/\/doi.org\/10.1111\/jcpe.13584.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"444_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.atherosclerosis.2015.08.032","volume":"243","author":"S Lakkur","year":"2015","unstructured":"Lakkur S, Judd S, Bostick RM, et al. Oxidative stress, inflammation, and markers of cardiovascular health. Atherosclerosis. 2015;243(1):38\u201343. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.08.032.","journal-title":"Atherosclerosis"},{"key":"444_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2021.100179","volume":"7","author":"E Gianos","year":"2021","unstructured":"Gianos E, Jackson EA, Tejpal A, et al. Oral health and atherosclerotic cardiovascular disease: a review. Am J Prev Cardiol. 2021;7:100179. https:\/\/doi.org\/10.1016\/j.ajpc.2021.100179.","journal-title":"Am J Prev Cardiol"},{"key":"444_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.998313","volume":"12","author":"Q Li","year":"2022","unstructured":"Li Q, Ouyang X, Lin J. The impact of periodontitis on vascular endothelial dysfunction. Front Cell Infect Microbiol. 2022;12:998313. https:\/\/doi.org\/10.3389\/fcimb.2022.998313.","journal-title":"Front Cell Infect Microbiol"},{"key":"444_CR34","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5781","volume":"2","author":"SJ Leishman","year":"2010","unstructured":"Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol. 2010;2:10.3402\/jom.v2i0.5781. https:\/\/doi.org\/10.3402\/jom.v2i0.5781.","journal-title":"J Oral Microbiol"},{"issue":"11","key":"444_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115876","volume":"22","author":"AS Plachokova","year":"2021","unstructured":"Plachokova AS, Andreu-S\u00e1nchez S, Noz MP, Fu J, Riksen NP. Oral microbiome in relation to periodontitis severity and systemic inflammation. Int J Mol Sci. 2021;22(11):5876. https:\/\/doi.org\/10.3390\/ijms22115876.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"444_CR36","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.amjmed.2023.11.022","volume":"137","author":"S Hopkins","year":"2024","unstructured":"Hopkins S, Gajagowni S, Qadeer Y, Wang Z, Virani SS, Meurman JH, et al. Oral health and cardiovascular disease. Am J Med. 2024;137(4):304\u20137. https:\/\/doi.org\/10.1016\/j.amjmed.2023.11.022.","journal-title":"Am J Med"},{"issue":"5","key":"444_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2025.111087","volume":"117","author":"M Zhu","year":"2025","unstructured":"Zhu M, Yang Y, Fang H, Chen R. Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1\/PI3K\/AKT-mediated mTOR-independent signaling pathway. Genomics. 2025;117(5):111087. https:\/\/doi.org\/10.1016\/j.ygeno.2025.111087.","journal-title":"Genomics"},{"key":"444_CR38","doi-asserted-by":"publisher","unstructured":"-Hansen PR, Holmstrup P. Cardiovascular Diseases and Periodontitis. Advances in experimental medicine and biology. 2022; 1373, 261\u2013280. https:\/\/doi.org\/10.1007\/978-3-030-96881-6_14","DOI":"10.1007\/978-3-030-96881-6_14"},{"issue":"28","key":"444_CR39","doi-asserted-by":"publisher","first-page":"19469","DOI":"10.1074\/jbc.M600399200","volume":"281","author":"K Lemmens","year":"2006","unstructured":"Lemmens K, Segers VF, Demolder M, De Keulenaer GW. Role of neuregulin-1\/ErbB2 signaling in endothelium-cardiomyocyte crosstalk. J Biol Chem. 2006;281(28):19469\u201377. https:\/\/doi.org\/10.1074\/jbc.M600399200.","journal-title":"J Biol Chem"},{"key":"444_CR40","doi-asserted-by":"publisher","unstructured":"-Kamel AHM, AlKindi F, AlHarrasi R, AlKindi N. The role of dental oncology in cancer care: a critical component of comprehensive Treatment, Education, and interdisciplinary Collaboration- a narrative review. J Cancer Educ 2025 Apr 30. https:\/\/doi.org\/10.1007\/s13187-025-02639-6","DOI":"10.1007\/s13187-025-02639-6"}],"container-title":["Cardio-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40959-026-00444-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-026-00444-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-026-00444-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:51:57Z","timestamp":1769676717000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40959-026-00444-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,10]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["444"],"URL":"https:\/\/doi.org\/10.1186\/s40959-026-00444-8","relation":{},"ISSN":["2057-3804"],"issn-type":[{"value":"2057-3804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,10]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee at the Sultan Qaboos Comprehensive Cancer Care and Research Centre (ID: CCCRC-109-2024 on 18th March 2025) following the Declaration of Helsinki and local regulatory guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}