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These patients were compared to non-cancer ACS patients via propensity score matching according to the cardiac risk factors age, sex, arterial hypertension and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found ACS, and overall Non-ST-elevation myocardial infarction (NSTEMI), as a relevant predictor of outcome in cancer patients with the highest mortality rates (88 deaths (40%) in non-cancer patients with NSTEMI vs. 174 deaths (64.9%), in the respective cancer patients\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable COX models including other comorbidities, cancer was found to independently influence mortality as well as cardiovascular hospital readmission (HR all-cause mortality: 1.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, HR readmission: 1.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Other risk factors, such as renal dysfunction, diabetes or impaired left ventricular function showed comparable influence on mortality. Percutaneous coronary intervention (PCI) rates did not differ between the groups (228\/441 non-cancer patients (51.7%) vs. 227\/441 cancer patients (51.5%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95), but optimized medical treatment was less present in the cancer group.\n                    <\/jats:p>\n                    <jats:p>\n                      In a subgroup of cancer patients with available biomarker data, NT-proBNP, but not hs-cTnT, was found to be useful for risk stratification (HR univariate: 1.28, HR multivariate considering risk factors and hs-cTnT: 1.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data indicate a relevant effect of ACS, especially NSTEMI, in cancer patients with impact on long-term mortality and cardiac morbidity. Cancer patients with NSTEMI warrant special care, considering comorbidities and optimized medical treatment of the cardiac disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40959-026-00451-9","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:46:50Z","timestamp":1770436010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of acute coronary syndrome on long-term survival in cancer patients"],"prefix":"10.1186","volume":"12","author":[{"given":"Daniel","family":"Finke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus B.","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Schug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas F.","family":"Entenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Hund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-8580","authenticated-orcid":false,"given":"Lorenz H.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"issue":"1","key":"451_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/EDE.0000000000000394","volume":"27","author":"PT Bradshaw","year":"2016","unstructured":"Bradshaw PT, Stevens J, Khankari N, Teitelbaum SL, Neugut AI, Gammon MD. 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