{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:49:01Z","timestamp":1746766141194,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Prophylactic antibiotics and neuromuscular blocking agents (NMBA) are two of the major causative agents of anaphylaxis after induction of anesthesia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>One female and one male patients (aged 29 and 69 years, respectively) had Ring and Messmer scale grade III anaphylaxis after administration of prophylactic antibiotics following induction of anesthesia. They showed typical hemodynamic and respiratory features of life-threatening anaphylaxis. Postoperative skin tests in these two patients were positive for antibiotics and concurrently positive for rocuronium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our present report suggests the possibility that both prophylactic antibiotics and NMBA concurrently and synergistically enhance anaphylactic reaction and the necessity to differentiate an immune mechanism from non-immune mechanisms when anesthesiologists encounter concurrent positive skin tests for both antibiotics and NMBA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-021-00440-0","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T14:08:13Z","timestamp":1618927693000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia"],"prefix":"10.1186","volume":"7","author":[{"given":"Masako","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-211X","authenticated-orcid":false,"given":"Katsuyuki","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo M.","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"issue":"1","key":"440_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bja.2018.04.014","volume":"121","author":"NJN Harper","year":"2018","unstructured":"Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, et al. Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6). Br J Anaesth. 2018;121(1):159\u201371. https:\/\/doi.org\/10.1016\/j.bja.2018.04.014.","journal-title":"Br J Anaesth"},{"issue":"1","key":"440_CR2","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1016\/j.bja.2019.04.044","volume":"123","author":"LH Garvey","year":"2019","unstructured":"Garvey LH, Dewachter P, Hepner DL, Mertes PM, Voltolini S, Clarke R, et al. Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Br J Anaesth. 2019;123(1):e50\u201364. https:\/\/doi.org\/10.1016\/j.bja.2019.04.044.","journal-title":"Br J Anaesth"},{"issue":"9","key":"440_CR3","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.lpm.2016.02.024","volume":"45","author":"PM Mertes","year":"2016","unstructured":"Mertes PM, Volcheck GW, Garvey LH, Takazawa T, Platt PR, Guttormsen AB, et al. Epidemiology of perioperative anaphylaxis. Press Medicale. 2016;45(9):758\u201367. https:\/\/doi.org\/10.1016\/j.lpm.2016.02.024.","journal-title":"Press Medicale"},{"issue":"1","key":"440_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s00540-020-02886-5","volume":"35","author":"T Horiuchi","year":"2021","unstructured":"Horiuchi T, Takazawa T, Orihara M, Sakamoto S, Nagumo K, Saito S. Drug-induced anaphylaxis during general anesthesia in 14 tertiary hospitals in Japan: a retrospective, multicenter, observational study. 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Anesth Essays Res. 2012;6(2):115\u201323. https:\/\/doi.org\/10.4103\/0259-1162.108284.","journal-title":"Anesth Essays Res"},{"issue":"2","key":"440_CR7","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/ALN.0000000000000276","volume":"121","author":"D Laroche","year":"2014","unstructured":"Laroche D, Gomis P, Gallimidi E, Malinovsky JM, Mertes PM. Diagnostic value of histamine and tryptase concentrations in severe anaphylaxis with shock or cardiac arrest during anesthesia. Anesthesiology. 2014;121(2):272\u20139. https:\/\/doi.org\/10.1097\/ALN.0000000000000276.","journal-title":"Anesthesiology"},{"issue":"1","key":"440_CR8","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1016\/j.bja.2019.01.002","volume":"123","author":"T Takazawa","year":"2019","unstructured":"Takazawa T, Sabato V, Ebo DG. In vitro diagnostic tests for perioperative hypersensitivity, a narrative review: potential, limitations, and perspectives. Br J Anaesth. 2019;123(1):e117\u201325. https:\/\/doi.org\/10.1016\/j.bja.2019.01.002.","journal-title":"Br J Anaesth"},{"issue":"1","key":"440_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.alit.2015.07.007","volume":"65","author":"N Hagau","year":"2016","unstructured":"Hagau N, Gherman N, Cocis M, Petrisor C. Antibiotic-induced immediate type hypersensitivity is a risk factor for positive allergy skin tests for neuromuscular blocking agents. Allergol Int. 2016;65(1):52\u20135. https:\/\/doi.org\/10.1016\/j.alit.2015.07.007.","journal-title":"Allergol Int"},{"issue":"6","key":"440_CR10","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/ijms18061223","volume":"18","author":"D Spoerl","year":"2017","unstructured":"Spoerl D, Nigolian H, Czarnetzki C, Harr T. Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed patho-mechanism: IgE-mediated, pharmacological adverse reaction or \u201cinnate hypersensitivity\u201d? Int J Mol Sci. 2017;18(6):1223. https:\/\/doi.org\/10.3390\/ijms18061223.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"440_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12948-018-0094-7","volume":"16","author":"E Di Leo","year":"2018","unstructured":"Di Leo E, Delle Donne P, Calogiuri GF, Macchia L, Nettis E. Focus on the agents most frequently responsible for perioperative anaphylaxis. Clin Mol Allergy. 2018;16(1):1\u20136. https:\/\/doi.org\/10.1186\/s12948-018-0094-7.","journal-title":"Clin Mol Allergy"},{"issue":"4","key":"440_CR12","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.jaip.2018.01.004","volume":"6","author":"DG Ebo","year":"2018","unstructured":"Ebo DG, Faber M, Elst J, Van Gasse AL, Bridts CH, Mertens C, et al. In vitro diagnosis of immediate drug hypersensitivity during anesthesia: a review of the literature. 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The approval date was Oct. 4, 2019.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We have obtained informed written consent for publication from all of the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}