{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:12:30Z","timestamp":1773666750289,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To prevent cardiac collapse and to protect cerebral function, hypothermic cardiopulmonary bypass is established before resternotomy. However, ventricular fibrillation under hypothermia facilitates left ventricular distension, which causes irreversible myocardial damage when the patient has aortic regurgitation. We report a case of successful management in preventing ventricular fibrillation under hypothermia by using nifekalant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 56-year-old male, who had been performed a David operation, was scheduled for a Bentall operation for a pseudo aortic aneurysm with severe aortic regurgitation. After inducing anesthesia, we administered intravenous nifekalant and a vent tube was inserted into the left ventricle under one-lung ventilation. Extracorporeal circulation was established and resternotomy started after cooling to 27 \u00b0C. Although severe bradycardia and QT prolongation were observed, ventricular fibrillation did not occur until aortic cross-clamping.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Combining maintaining cerebral perfusion and avoiding left ventricle distension during hypothermia was successfully managed with nifekalant in our redo cardiac patient with aortic regurgitation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-021-00446-8","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T22:02:15Z","timestamp":1621548135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anesthetic management of a patient with severe aortic regurgitation undergoing reoperation for ascending aorta false aneurysm using hypothermia: prevention of ventricular fibrillation by nifekalant"],"prefix":"10.1186","volume":"7","author":[{"given":"Akiko","family":"Tomita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"issue":"3","key":"446_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1510\/icvts.2009.232090","volume":"11","author":"D Morales","year":"2010","unstructured":"Morales D, Williams E, John R. Is resternotomy in cardiac surgery still a problem? Interact Cardiovasc Thorac Surg. 2010;11(3):277\u201386. https:\/\/doi.org\/10.1510\/icvts.2009.232090.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"3","key":"446_CR2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1540-8191.2010.01014.x","volume":"25","author":"F Moller","year":"2010","unstructured":"Moller F, Liska J, Lockowandt U, Samuelsson S, Franco-Cereceda A. Resternotomy using hypothermic arrest. J Card Surg. 2010;25(3):272\u20136. https:\/\/doi.org\/10.1111\/j.1540-8191.2010.01014.x.","journal-title":"J Card Surg"},{"issue":"5","key":"446_CR3","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/ejcts\/ezw163","volume":"50","author":"O Preventza","year":"2016","unstructured":"Preventza O, Garcia A, Kashyap SA, Akvan S, Cooley DA, Simpson K, et al. Moderate hypothermia \u226524 and \u226428\u00b0C with hypothermic circulatory arrest for proximal aortic operations in patients with previous cardiac surgery. Eur J Cardiothorac Surg. 2016;50(5):949\u201354. https:\/\/doi.org\/10.1093\/ejcts\/ezw163.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"446_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1161\/01.RES.10.2.148","volume":"10","author":"BG Covino","year":"1962","unstructured":"Covino BG, D\u2019Amato HE. Mechanism of ventricular fibrillation in hypothermia. Circ Res. 1962;10(2):148\u201355. https:\/\/doi.org\/10.1161\/01.RES.10.2.148.","journal-title":"Circ Res"},{"key":"446_CR5","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1152\/ajpheart.00986.2007","volume":"294","author":"M Harada","year":"2008","unstructured":"Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro YS, Okuno Y, et al. Moderate hypothermia increases the chance of spiral wave collision in favor of self-termination of ventricular tachycardia\/fibrillation. Am J Physiol Heart Circ Physiol. 2008;294:1896\u2013905.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"446_CR6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1536\/jhj.40.179","volume":"40","author":"H Tachibana","year":"1999","unstructured":"Tachibana H, Kubota I, Yamaki M, Watanabe T, Tomoike H. Canine model of ventricular fibrillaton using programmed stimuli and localized myocardial warming or cooling. Jpn Heart J. 1999;40(2):179\u201388. https:\/\/doi.org\/10.1536\/jhj.40.179.","journal-title":"Jpn Heart J"},{"issue":"12","key":"446_CR7","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1056\/NEJM199909163411203","volume":"341","author":"PJ Kudenchuk","year":"1999","unstructured":"Kudenchuk PJ, Cobb LA, Copass MK, Cummins RO, Doherty AM, Fahrenbruch CE, et al. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. N Engl J Med. 1999;341(12):871\u20138. https:\/\/doi.org\/10.1056\/NEJM199909163411203.","journal-title":"N Engl J Med"},{"issue":"12","key":"446_CR8","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1056\/NEJMoa013029","volume":"346","author":"P Dorian","year":"2002","unstructured":"Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med. 2002;346(12):884\u201390. https:\/\/doi.org\/10.1056\/NEJMoa013029.","journal-title":"N Engl J Med"},{"issue":"4","key":"446_CR9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00540-013-1775-5","volume":"28","author":"N Harayama","year":"2014","unstructured":"Harayama N, Nihei S, Nagata K, Isa Y, Goto K, Aibara K, et al. 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