{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:43:58Z","timestamp":1765547038950,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ondansetron is an antiemetic drug that is useful not only for prevention but also for the treatment of postoperative nausea and vomiting (PONV). We report a rare case of drowsiness in a child after using ondansetron for nausea on the day after general anesthesia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 5-year-old boy underwent circumcision under general anesthesia and suffered from postoperative nausea and vomiting. He was administered 0.1mg\/kg of ondansetron in the PACU and 23 h later on the day after surgery. After the second dose, he acutely exhibited drowsiness which resolved in 3 h. He was discharged to home later on the same day. He was not given any other drugs at the time, and the drowsiness was thought to be directly attributable to ondansetron, though the exact mechanism was unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>When drowsiness or other cognitive symptoms are observed after administration of ondansetron, it must be considered and managed as a possible side effect.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-023-00599-8","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:03:13Z","timestamp":1675908193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drowsiness following ondansetron given the day after general anesthesia for postoperative nausea: a pediatric case report"],"prefix":"10.1186","volume":"9","author":[{"given":"Machiko","family":"Furuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoyuki","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-7826","authenticated-orcid":false,"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"599_CR1","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/pan.12908","volume":"26","author":"J Lee","year":"2016","unstructured":"Lee J, Faraoni D, Lee S, Brown M, Odegard K, Randolph A, et al. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016;26:644\u20138.","journal-title":"Paediatr Anaesth."},{"key":"599_CR2","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1213\/01.ANE.0000135639.57715.6C","volume":"99","author":"LHJ Eberhart","year":"2004","unstructured":"Eberhart LHJ, Geldner G, Kranke P, Morin AM, Schauffelen A, Treiber H, et al. The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesth Analg. 2004;99:1630\u20137.","journal-title":"Anesth Analg."},{"key":"599_CR3","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/pan.12428","volume":"24","author":"N Bourdaud","year":"2014","unstructured":"Bourdaud N, Devys JM, Bientz J, Lejus C, Hebrard A, Tirel O, et al. Development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients: the VPOP score. Paediatr Anaesth. 2014;24:945\u201352.","journal-title":"Paediatr Anaesth."},{"key":"599_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","volume":"131","author":"TJ Gan","year":"2020","unstructured":"Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131:411\u201348.","journal-title":"Anesth Analg."},{"key":"599_CR5","unstructured":"Malviya S, Polaner DM, Berde CB. Acute pain. In: Cote CJ, Lerman J, Anderson B, editors. A practice of anesthesia for infants and children. 5th ed. Philadelphia: Elsevier; 2012. p. 909\u201350."},{"key":"599_CR6","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1097\/00000542-199712000-00004","volume":"87","author":"MRRD Tramer","year":"1997","unstructured":"Tramer MRRD, Moore RA, McQuay HJ. Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting. Anesthesiology. 1997;87:1277\u201389.","journal-title":"Anesthesiology."},{"key":"599_CR7","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1213\/00000539-199709000-00011","volume":"85","author":"RIDP Patel","year":"1997","unstructured":"Patel RIDP, Orr RJ, Ferrari LR, Rimar S, Hannallah RS, Cohen IT, et al. Single-dose ondansetron prevents postoperative vomiting in pediatric outpatients. Anesth Anal. 1997;85:538\u201345.","journal-title":"Anesth Anal"},{"key":"599_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1213\/01.ANE.0000155261.27335.29","volume":"101","author":"SNRA Khalil","year":"2005","unstructured":"Khalil SNRA, Cohen IT, Simhi E, Ansermino JM, Bolos ME, Cot\u00e9 CJ, et al. A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia. Anesth Anal. 2005;101:356\u201361.","journal-title":"Anesth Anal"},{"key":"599_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/j.1552-4604.1996.tb04190.x","volume":"36","author":"WD Figg","year":"1996","unstructured":"Figg WD, Dukes G, Pritchard JF, Hermann DJLH, Carson SW, Songer SS, et al. Pharmacokinetics of ondansetron in patients with hepatic insufficiency. J Clin Pharmacol. 1996;36:206\u201315.","journal-title":"J Clin Pharmacol."},{"key":"599_CR10","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/0009-9236(95)90248-1","volume":"58","author":"IALJ Spahr-Schopfer","year":"1995","unstructured":"Spahr-Schopfer IALJ, Sikich N, Palmer J, Jorch U. Pharmacokinetics of intravenous ondansetron in healthy children undergoing ear, nose, and throat surgery. 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Expert Opin Drug Metab Toxicol. 2014;10:437\u201344.","journal-title":"Expert Opin Drug Metab Toxicol."}],"container-title":["JA Clinical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-023-00599-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40981-023-00599-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-023-00599-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:06:15Z","timestamp":1675908375000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaclinicalreports.springeropen.com\/articles\/10.1186\/s40981-023-00599-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["599"],"URL":"https:\/\/doi.org\/10.1186\/s40981-023-00599-8","relation":{},"ISSN":["2363-9024"],"issn-type":[{"type":"electronic","value":"2363-9024"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent for publication was obtained from the patient\u2019s guardian.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}