{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:15:38Z","timestamp":1776294938138,"version":"3.50.1"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neuromodulation by magnetic field through the AT-04 (ait\u00ae (AT-04); Peace of Mind Co., Ltd., Kumamoto, Japan) has improved allodynia in neuropathic pain model rats. This report focuses on neuromodulation through magnetic field exposure using the AT-04 that provided an analgesic effect in a patient with neuropathic pain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 47-year-old man presented with flaccid paralysis and extensive neuropathic pain and scored 7 on the 11-point Numerical Rating Scale (NRS) for his left upper limb. The patient was treated with neuromodulation by magnetic field exposure using the AT-04. Baseline NRS scores were obtained three times daily during the baseline period (days 1\u20135). Magnetic field exposure was then performed for 30\u00a0min three times daily (morning, noon, and evening) at home for 36\u00a0days, which was termed the intervention period (days 6\u201341). During the baseline period, the median NRS score was 7 and the baseline NRS score for calculating the percentage of nonoverlap data (PND) was 6. During the intervention period, the median NRS score was 4 and the PND value of the NRS score was 77.8% (28\/36). Neuromodulation by magnetic field exposure using the AT-04 effectively decreased the patient\u2019s NRS score. The patient had no adverse effects during the intervention period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Neuromodulation by magnetic field exposure using the AT-04 was effective in decreasing the NRS score in a patient with neuropathic pain. The AT-04 portable magnetic field-generating device shows potential as a therapeutic option for refractory neuropathic pain.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-024-00694-4","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T03:02:31Z","timestamp":1707534151000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analgesic effect of neuromodulation using the AT-04 portable magnetic field-generating device in a patient with neuropathic pain: a case report"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-8736","authenticated-orcid":false,"given":"Atsushi","family":"Sawada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Yamakage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"694_CR1","first-page":"CD011976","volume":"9","author":"W Gibson","year":"2017","unstructured":"Gibson W, Wand BM, O\u2019Connell NE. Transcutaneous electrical stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev. 2017;9:CD011976.","journal-title":"Cochrane Database Syst Rev."},{"key":"694_CR2","doi-asserted-by":"publisher","first-page":"651","DOI":"10.2147\/JPR.S37589","volume":"7","author":"T Wolter","year":"2014","unstructured":"Wolter T. Spinal cord stimulation for neuropathic pain: current perspectives. J Pain Res. 2014;7:651\u201363.","journal-title":"J Pain Res"},{"key":"694_CR3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/pm\/pnz064","volume":"21","author":"H Oka","year":"2020","unstructured":"Oka H, Miki K, Kishita I, Kong DF, Uchida T. A multicenter, prospective, randomized, placebo-controlled, double-blind study of a novel pain management device, AT-02, in patients with fibromyalgia. Pain Med. 2020;21:326\u201332.","journal-title":"Pain Med"},{"key":"694_CR4","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1007\/s10571-023-01430-9","volume":"43","author":"T Kohno","year":"2023","unstructured":"Kohno T, Takaki K, Kishita K, Mitsutake K, Tofuku N, Kishita I. Neuromodulation through magnetic fields irradiation with AT-04 improves hyperalgesia in a rat model of neuropathic pain via descending pain modulatory systems and opioid analgesia. Cell Mol Neurobiol. 2023;43:4345\u201362.","journal-title":"Cell Mol Neurobiol"},{"key":"694_CR5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/01454455980223001","volume":"22","author":"TE Scruggs","year":"1998","unstructured":"Scruggs TE, Mastropieri MA. Summarizing single-subject research. Issues and applications. Behav Modif. 1998;22:221\u201342.","journal-title":"Behav Modif"},{"key":"694_CR6","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s40122-021-00255-y","volume":"10","author":"Y Kimura","year":"2021","unstructured":"Kimura Y, Yamaguchi S, Suzuki T, Kato J, Chiba S, Hirakawa N, et al. Switching from pregabalin to mirogabalin in patients with peripheral neuropathic pain: a multi-center, prospective, single-arm, open-label study (MIROP study). Pain Ther. 2021;10:711\u201327.","journal-title":"Pain Ther"},{"key":"694_CR7","first-page":"CD006146","volume":"8","author":"ED McNicol","year":"2013","unstructured":"McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. Cochrane Database Syst Rev. 2013;8:CD006146.","journal-title":"Cochrane Database Syst Rev."},{"key":"694_CR8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neulet.2003.11.037","volume":"356","author":"B Pleger","year":"2004","unstructured":"Pleger B, Janssen F, Schwenkreis P, V\u00f6lker B, Maier C, Tegenthoff M. Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I. Neurosci Lett. 2004;356:87\u201390.","journal-title":"Neurosci Lett"}],"container-title":["JA Clinical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00694-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40981-024-00694-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00694-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T03:06:24Z","timestamp":1707534384000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaclinicalreports.springeropen.com\/articles\/10.1186\/s40981-024-00694-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,10]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["694"],"URL":"https:\/\/doi.org\/10.1186\/s40981-024-00694-4","relation":{},"ISSN":["2363-9024"],"issn-type":[{"value":"2363-9024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,10]]},"assertion":[{"value":"11 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this care report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}