{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:28:37Z","timestamp":1781738917877,"version":"3.54.5"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Previous reports have described hiccups during general anesthesia that were possibly induced by drugs, including benzodiazepines. However, there are few reports of hiccups caused by remimazolam.<\/jats:p>\n                <jats:p>Case presentation<\/jats:p>\n                <jats:p>A 75-year-old woman underwent corneal transplantation under general anesthesia with remimazolam. She presented with hiccups once the effects of muscle relaxants used during induction wore off, which persisted even after various treatments, such as the administration of antipsychotic drugs. However, when remimazolam administration was terminated after surgery to awaken the patient, the hiccups stopped and did not recur after extubation. Evaluation of predicted blood levels of remimazolam suggests that higher levels of remimazolam might cause hiccups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Remimazolam might induce hiccups during general anesthesia. Anesthesiologists should consider administering muscle relaxants or changing the anesthetic in cases of refractory hiccups under general anesthesia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-024-00714-3","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:01:46Z","timestamp":1716523306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment-resistant hiccups during general anesthesia possibly caused by remimazolam: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"Miku","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-3532","authenticated-orcid":false,"given":"Tomonori","family":"Takazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Kabasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Nagumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"714_CR1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1177\/106002809703100318","volume":"31","author":"DF Thompson","year":"1997","unstructured":"Thompson DF, Landry JP. Drug-induced hiccups. Ann Pharmacother. 1997;31:367\u20139.","journal-title":"Ann Pharmacother"},{"key":"714_CR2","first-page":"53","volume":"50","author":"T Oshima","year":"2002","unstructured":"Oshima T, Doi S. GABA and hiccups. Resp Circul. 2002;50:53\u20137.","journal-title":"Resp Circul"},{"key":"714_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00540-022-03079-y","volume":"36","author":"K Masui","year":"2022","unstructured":"Masui K, St\u00f6hr T, Pesic M, Tonai T. A population pharmacokinetic model of remimazolam for general anesthesia and consideration of remimazolam dose in clinical practice. J Anesth. 2022;36:493\u2013505.","journal-title":"J Anesth"},{"issue":"11","key":"714_CR4","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1111\/bcp.15839","volume":"89","author":"E Ye","year":"2023","unstructured":"Ye E, Wu K, Ye H, Zhang W, Chu L, Zhang K, Xie G, Jin Y, Fang X. Comparison of 95% effective dose of remimazolam besylate and propofol for gastroscopy sedation on older patients: a single-centre randomized controlled trial. Br J Clin Pharmacol. 2023;89(11):3401\u201310.","journal-title":"Br J Clin Pharmacol"},{"issue":"652","key":"714_CR5","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3399\/bjgp16X687913.","volume":"66","author":"J Bra\u00f1uelas Quiroga","year":"2016","unstructured":"Bra\u00f1uelas Quiroga J, Urbano Garc\u00eda J, Bola\u00f1os Guedes J. Hiccups: a common problem with some unusual causes and cures. Br J Gen Pract. 2016;66(652):584\u20136. https:\/\/doi.org\/10.3399\/bjgp16X687913. Erratum.In:BrJGenPract.2017Jan;67(654):13.PMID:27789508;PMCID:PMC5072913.","journal-title":"Br J Gen Pract."},{"key":"714_CR6","doi-asserted-by":"publisher","first-page":"e01597","DOI":"10.1213\/XAA.0000000000001597","volume":"16","author":"K Shimada","year":"2022","unstructured":"Shimada K, Inokuchi R, Tominaga K, Yagihashi S, Yamada M, Ishitsuka S. Effective treatment of intraoperative hiccups with chlorpromazine under general anesthesia without muscle relaxants: a case report. A&A Pract. 2022;16:e01597.","journal-title":"A&A Pract"}],"container-title":["JA Clinical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00714-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40981-024-00714-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00714-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T12:13:01Z","timestamp":1725451981000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaclinicalreports.springeropen.com\/articles\/10.1186\/s40981-024-00714-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1186\/s40981-024-00714-3","relation":{},"ISSN":["2363-9024"],"issn-type":[{"value":"2363-9024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}