{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:08:09Z","timestamp":1769098089189,"version":"3.49.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The skin-prick and intradermal tests are the main diagnostic methods used to identify the causative agent in patients with suspected perioperative anaphylaxis. Although the intradermal test is more sensitive than the skin-prick test, multiple intradermal injections can be painful for children. Here, we present the case of a child with autism and suspected perioperative anaphylaxis. The causative agent was successfully identified using the intradermal test under general anesthesia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An 8-year-old boy with autism developed anaphylaxis during general anesthesia for the fourth cleft lip and palate surgery. An allergic workout was performed, but both the skin-prick and basophil activation tests for suspected causative agents yielded negative results. The patient was afraid of multiple injections, and an intradermal test was performed under general anesthesia by anesthesiologists and allergists. Piperacillin was confirmed as the causative agent, and subsequent surgery using the same anesthetic agents without piperacillin was uneventful.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Concerted efforts should be made to identify the causative agent for diagnosing perioperative anaphylaxis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40981-024-00733-0","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:02:26Z","timestamp":1723118546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Causative agent for perioperative anaphylaxis in a child with autism successfully identified using the intradermal test under general anesthesia"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-9801","authenticated-orcid":false,"given":"Yasuhiro","family":"Amano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasuku","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"733_CR1","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1111\/all.13820","volume":"74","author":"LH Garvey","year":"2019","unstructured":"Garvey LH, Ebo DG, Mertes PM, Dewachter P, Garcez T, Kopac P, et al. An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions. Allergy. 2019;74:1872\u201384. https:\/\/doi.org\/10.1111\/all.13820.","journal-title":"Allergy"},{"key":"733_CR2","unstructured":"Scolaro RJ, Crilly HM, Maycock EJ, McAleer PT, Nicholls KA, Rose MA, et al. Australian and New Zealand Anaesthetic Allergy Group (ANZAAG) perioperative anaphylaxis investigation guidelines. https:\/\/media.anzaag.com\/2022\/09\/26104018\/testing-guidelines.pdf. Accessed 25 Apr 2024."},{"key":"733_CR3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/all.12774","volume":"71","author":"ER Gomes","year":"2016","unstructured":"Gomes ER, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, et al. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy. 2016;71:149\u201361. https:\/\/doi.org\/10.1111\/all.12774.","journal-title":"Allergy"},{"key":"733_CR4","doi-asserted-by":"publisher","unstructured":"Takazawa T, Yamaura K, Hara T, Yorozu T, Mitsuhata H, Morimatsu H; Working Group for the Preparation of Practical Guidelines for the Response to Anaphylaxis, Safety Committee of the Japanese Society of Anesthesiologists. Practical guidelines for the response to perioperative anaphylaxis. J Anesth. 2021;35:778\u2013793. https:\/\/doi.org\/10.1007\/s00540-021-03005-8.","DOI":"10.1007\/s00540-021-03005-8"},{"key":"733_CR5","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1016\/j.bja.2019.02.029","volume":"123","author":"PM Hopkins","year":"2019","unstructured":"Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, Platt PR, Dewachter P, et al. Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. Br J Anaesth. 2019;123:e29\u201337. https:\/\/doi.org\/10.1016\/j.bja.2019.02.029.","journal-title":"Br J Anaesth"},{"key":"733_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/bja\/aei198","volume":"95","author":"M Kr\u00f8igaard","year":"2005","unstructured":"Kr\u00f8igaard M, Garvey LH, Menn\u00e9 T, Husum B. Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing? Br J Anaesth. 2005;95:468\u201371. https:\/\/doi.org\/10.1093\/bja\/aei198.","journal-title":"Br J Anaesth"},{"key":"733_CR7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000328760","volume":"157","author":"P Valent","year":"2012","unstructured":"Valent P, Akin C, Arock M, Brockow K, Butterfield JH, Carter MC, et al. Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int Arch Allergy Immunol. 2012;157:215\u201325. https:\/\/doi.org\/10.1159\/000328760.","journal-title":"Int Arch Allergy Immunol"},{"issue":"9","key":"733_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjao.2023.100254","volume":"17","author":"N Vlaeminck","year":"2024","unstructured":"Vlaeminck N, Poorten MV, Nygaard Madsen C, Bech Melchiors B, Michel M, Gonzalez C, et al. Paediatric perioperative hypersensitivity: the performance of the current consensus formula and the effect of uneventful anaesthesia on serum tryptase. BJA Open. 2024;17(9): 100254. https:\/\/doi.org\/10.1016\/j.bjao.2023.100254.","journal-title":"BJA Open"},{"key":"733_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11882-020-00911-x","volume":"20","author":"M Ma","year":"2020","unstructured":"Ma M, Zhu B, Zhao J, Li H, Zhou L, Wang M, et al. 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Br J Anaesth. 2010;105:106\u201315. https:\/\/doi.org\/10.1093\/bja\/aeq164.","journal-title":"Br J Anaesth"}],"container-title":["JA Clinical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00733-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40981-024-00733-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-024-00733-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:08:04Z","timestamp":1723118884000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaclinicalreports.springeropen.com\/articles\/10.1186\/s40981-024-00733-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["733"],"URL":"https:\/\/doi.org\/10.1186\/s40981-024-00733-0","relation":{},"ISSN":["2363-9024"],"issn-type":[{"value":"2363-9024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"12 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case was included in an observational study of perioperative anaphylaxis approved by the institutional review board of Nagoya University Hospital (approval number: 2020\u20130020). Basophil activation tests performed at Fujita Health University Bantane Hospital were approved by the institutional review board of Fujita Health University (approval number: HM23-458).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent was obtained from the patient\u2019s parents for publication of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}