{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:58:18Z","timestamp":1781629098170,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JA Clin Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to evaluate the concordance between facial flushing assessment using an objective color sensor and subjective visual assessment in patients with mesenteric traction syndrome (MTS), to inform the design of a future large-scale study that incorporates objective diagnostic tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective pilot study, we enrolled adult patients who underwent pancreatectomy. Anesthesiologists assessed the degree of facial flushing subjectively using a scale of levels 0\u20132. Simultaneously, the Nix color sensor objectively measured the facial redness (a-value) at four facial points. Heart rate and arterial blood pressure were also recorded. Based on the anesthesiologist\u2019s diagnosis, patients were categorized into either the MTS or non-MTS group. We compared the ratio of changes in a-value, heart rate, and blood pressure between the two groups, and their thresholds were also calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 38 patients: 14 in the MTS group and 24 in the non-MTS group. The MTS group showed significantly higher median change ratio in a-value (0.45 vs. 0.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and heart rate (0.45 vs. 0.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and a greater decrease in mean arterial pressure (-0.26 vs. -0.14,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) than the non-MTS group. Subjective flushing levels correlated with MTS diagnosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). While the Nix sensor detected flushing in some subjectively undiagnosed cases, one patient in the non-MTS group met all three objective thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Objective evaluation of facial flushing using a color sensor is feasible and may enhance conventional assessment methods. To further improve the accuracy of objective evaluation, this pilot study may lead to a larger-scale study including blood tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40981-025-00843-3","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:05:49Z","timestamp":1767686749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective evaluation of facial flushing for mesenteric traction syndrome diagnosis during laparotomy: a prospective observational pilot study"],"prefix":"10.1186","volume":"12","author":[{"given":"Yutaro","family":"Ikki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Negita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimitoshi","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-9988","authenticated-orcid":false,"given":"Takahiro","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"843_CR1","first-page":"V09130546","volume":"176","author":"PS Krohn","year":"2014","unstructured":"Krohn PS, Ambrus R, Zaar M, Secher NH, Svendsen LB. 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Bone Marrow Transpl. 2013;48:452\u20138.","journal-title":"Bone Marrow Transpl"},{"key":"843_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12871-016-0256-4","volume":"16","author":"R Ambrus","year":"2016","unstructured":"Ambrus R, Strandby RB, Secher NH, R\u00fcnitz K, Svendsen MB, Petersen LG, et al. Thoracic epidural analgesia reduces gastric microcirculation in the pig. BMC Anesthesiol. 2016;16:86.","journal-title":"BMC Anesthesiol"},{"key":"843_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.24.8.080901","volume":"24","author":"W Heeman","year":"2019","unstructured":"Heeman W, Steenbergen W, van Dam G, Boerma EC. Clinical applications of laser speckle contrast imaging: A review. J Biomed Opt. 2019;24:1\u201311.","journal-title":"J Biomed Opt"},{"key":"843_CR18","first-page":"3661","volume":"58","author":"CS Schelkopf","year":"2021","unstructured":"Schelkopf CS, Rice EA, Swenson JK, Hess AM, Geornaras I, Belk KE, et al. Nix pro color sensor provides comparable color measurements to HunterLab colorimeter for fresh beef. J Food Sci Technol. 2021;58:3661\u20135.","journal-title":"J Food Sci Technol"}],"container-title":["JA Clinical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40981-025-00843-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-025-00843-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40981-025-00843-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:09:29Z","timestamp":1781626169000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40981-025-00843-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["843"],"URL":"https:\/\/doi.org\/10.1186\/s40981-025-00843-3","relation":{},"ISSN":["2363-9024"],"issn-type":[{"value":"2363-9024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"15 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Review Committees of Nagoya University Hospital (approval number: 2023\u2009\u2212\u20090127) and Handa City Hospital (approval number: 2024-007), and written informed consent was obtained from all participants. This study was also registered with the University Hospital Medical Research Network (approval number: UMIN000051642).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Yutaro Ikki, Takeshi Negita, Kimitoshi Nishiwaki, and Takahiro Tamura declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6"}}