{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:29Z","timestamp":1792788569675,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Peking Union Medical College Hospital Central High-Level Hospital Clinical Research Special Projec","award":["2026-PUMCH-A-083"],"award-info":[{"award-number":["2026-PUMCH-A-083"]}],"id":[{"id":"https:\/\/ror.org\/04jztag35","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin Neurosurg Jl"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heart\u2013brain comorbidities present unique diagnostic and therapeutic challenges because neurological and cardiac conditions often share pathophysiological mechanisms yet create conflicting treatment demands. Multidisciplinary wards integrating neurosurgery, cardiac surgery, cardiology, and neurology have been proposed, but real-world experience remains limited. We report the initial experience of a dedicated heart\u2013brain integrated ward at a Chinese tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective descriptive study of all consecutive patients admitted to the Heart\u2013Brain Integrated Ward at Peking Union Medical College Hospital between July 1 and August 21, 2026. Clinical data were entered prospectively into the electronic medical record during routine care and analyzed retrospectively. Variables included demographics, neurological and cardiac diagnoses, a six-category comorbidity classification, MDT decisions, treatment strategies, and discharge outcomes. Treatment categories were predefined as: (i) diagnostic procedures, (ii) therapeutic single-system interventions, (iii) staged dual-system treatment within the same admission, and (iv) synchronous dual-system treatment in a single session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-six patients (42 males, 75.0%; mean age 62.4\u2009\u00b1\u200912.2\u00a0years, range 19\u201380) were enrolled. The most common category was I.1 (shared atherosclerotic vascular disease; 29\/56, 51.8%), predominantly ischemic cerebrovascular disease with coronary artery disease (18\/56, 32.1%). Category IV (psychocardiological disorders) accounted for 12 patients (21.4%), and Category V (therapeutically interactive) for 3 (5.4%). All patients underwent at least one MDT discussion (100%), and 55 (98.2%) required a second. Of 56 patients, 41 (73.2%) underwent surgical or endovascular intervention and 15 (26.8%) received medical management or remained under evaluation. Among treated patients, 4 (7.1%) received synchronous dual-system procedures, 13 (23.2%) completed staged procedures within the same admission, and 24 (42.9%) underwent single-system intervention. Fourteen patients (25.0%) required intervention for both organ systems. No in-hospital mortality or major procedure-related complications were observed among 38 discharged patients (67.9%); 18 patients (32.1%) remained hospitalized at data cutoff.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Establishing a dedicated heart\u2013brain integrated ward at a tertiary referral center appears operationally feasible and enables structured MDT-based care for complex neuro-cardiac patients. The early disease spectrum is dominated by atherosclerotic pan-vascular disease. Synchronous dual-system procedures were performed in a small selected subset without observed major early events among discharged patients, but this cannot establish safety or generalizability. Larger prospective studies with controlled comparisons and longer follow-up are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41016-026-00451-9","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:33:53Z","timestamp":1791822833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early experience of a dedicated heart\u2013brain integrated ward at Peking Union Medical College Hospital: a retrospective descriptive study"],"prefix":"10.1186","volume":"12","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"4","key":"451_CR1","first-page":"547","volume":"25","author":"W Doehner","year":"2023","unstructured":"Doehner W, B\u00f6hm M, Boriani G, et al. Interaction of heart failure and stroke: a clinical consensus statement. Eur J Heart Fail. 2023;25(4):547\u201362.","journal-title":"Eur J Heart Fail"},{"issue":"21","key":"451_CR2","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1001\/jama.1983.03340210040022","volume":"250","author":"WB Kannel","year":"1983","unstructured":"Kannel WB, Wolf PA, Verter J. Manifestations of coronary disease predisposing to stroke: the Framingham study. JAMA. 1983;250(21):2942\u20136.","journal-title":"JAMA"},{"issue":"1","key":"451_CR3","first-page":"8","volume":"24","author":"Y Shang","year":"2024","unstructured":"Shang Y, Wang X, Tong X, et al. Surgery and prospect of brain\u2013heart co-treatment in the era of pan-vascular medicine. Chin J Contemp Neurol Neurosurg. 2024;24(1):8\u201316.","journal-title":"Chin J Contemp Neurol Neurosurg"},{"issue":"15","key":"451_CR4","first-page":"e025200","volume":"11","author":"JF Scheitz","year":"2022","unstructured":"Scheitz JF, Sposato LA, Schulz-Menger J, et al. Stroke\u2013heart syndrome: recent advances and challenges. J Am Heart Assoc. 2022;11(15):e025200.","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"451_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/23969873241264115","volume":"10","author":"KL Hoad","year":"2025","unstructured":"Hoad KL, Jones H, Miller G, et al. Stroke\u2013heart syndrome: incidence and clinical outcomes of cardiac complications after intracerebral hemorrhage. Eur Stroke J. 2025;10(1):100\u20137.","journal-title":"Eur Stroke J"},{"issue":"10","key":"451_CR6","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.jacc.2008.04.062","volume":"52","author":"MR Di Tullio","year":"2008","unstructured":"Di Tullio MR, Homma S, Jin Z, Sacco RL. Aortic atherosclerosis, hypercoagulability, and stroke: the APRIS study. J Am Coll Cardiol. 2008;52(10):855\u201361.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"451_CR7","first-page":"e14234","volume":"11","author":"M Massussi","year":"2024","unstructured":"Massussi M, et al. Connecting the dots: heart failure and cognitive impairment. ESC Heart Fail. 2024;11(3):e14234.","journal-title":"ESC Heart Fail"},{"issue":"7","key":"451_CR8","doi-asserted-by":"publisher","first-page":"e007694","DOI":"10.1161\/JAHA.117.007694","volume":"7","author":"MG Adamski","year":"2018","unstructured":"Adamski MG, et al. Vascular cognitive impairment linked to brain endothelium inflammation in early heart failure. J Am Heart Assoc. 2018;7(7):e007694.","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"451_CR9","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.3390\/jcm10235623","volume":"10","author":"E Bellettini","year":"2021","unstructured":"Bellettini E, De Luca L, Dichtl W, et al. Antithrombotic therapy in patients with coronary artery disease and prior stroke. J Clin Med. 2021;10(23):5623.","journal-title":"J Clin Med"},{"issue":"11","key":"451_CR10","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.3390\/jcm13113019","volume":"13","author":"A Xodo","year":"2024","unstructured":"Xodo A, Gregio A, Pilon F, et al. Carotid interventions in patients undergoing CABG: a narrative review. J Clin Med. 2024;13(11):3019.","journal-title":"J Clin Med"},{"issue":"13","key":"451_CR11","doi-asserted-by":"crossref","first-page":"e2307798","DOI":"10.1002\/advs.202307798","volume":"11","author":"X Fan","year":"2024","unstructured":"Fan X, Cao J, Li M, et al. Stroke-related brain\u2013heart crosstalk: pathophysiology and clinical implications. Adv Sci. 2024;11(13):e2307798.","journal-title":"Adv Sci"},{"issue":"1","key":"451_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejvs.2022.04.011","volume":"65","author":"AR Naylor","year":"2023","unstructured":"Naylor AR, et al. ESVS 2023 guidelines on management of atherosclerotic carotid and vertebral artery disease. Eur J Vasc Endovasc Surg. 2023;65(1):9\u2013205.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"451_CR13","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.avsg.2022.05.027","volume":"86","author":"C Peng","year":"2022","unstructured":"Peng C, Zhou J, Wang S, et al. Staged versus synchronous CEA and CABG: a meta-analysis. Ann Vasc Surg. 2022;86:428\u201339.","journal-title":"Ann Vasc Surg"},{"issue":"14","key":"451_CR14","first-page":"E415","volume":"198","author":"JJ Lang","year":"2026","unstructured":"Lang JJ, et al. Management of brain\u2013heart multimorbidity: C-CHANGE 2026 clinical practice guideline. CMAJ. 2026;198(14):E415\u201324.","journal-title":"CMAJ"},{"issue":"23","key":"451_CR15","doi-asserted-by":"publisher","first-page":"7180","DOI":"10.3390\/jcm13237180","volume":"13","author":"M Fiorentino","year":"2024","unstructured":"Fiorentino M, et al. Simultaneous CAS and CABG in urgent patients: a single-center experience. J Clin Med. 2024;13(23):7180.","journal-title":"J Clin Med"},{"issue":"15","key":"451_CR16","first-page":"1081","volume":"104","author":"Chinese College of Cardiovascular Physicians","year":"2024","unstructured":"Chinese College of Cardiovascular Physicians. Chinese expert consensus on antithrombotic therapy for pan-vascular diseases (2024). Natl Med J China. 2024;104(15):1081\u201396.","journal-title":"Natl Med J China"}],"container-title":["Chinese Neurosurgical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41016-026-00451-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41016-026-00451-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41016-026-00451-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:33:55Z","timestamp":1791822835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s41016-026-00451-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["451"],"URL":"https:\/\/doi.org\/10.1186\/s41016-026-00451-9","relation":{},"ISSN":["2057-4967"],"issn-type":[{"value":"2057-4967","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"24 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This was a retrospective descriptive study conducted at the Heart\u2013Brain Integrated Ward of PUMCH, Beijing, China. The study period covered July 1 through August 21, 2026. In consultation with the Institutional Review Board of PUMCH (1-26YJ0951), the study was deemed exempt from full ethical review due to its retrospective, de-identified nature; the requirement for individual informed consent was waived. Clinical data were entered prospectively into the electronic medical record during routine care and were analyzed retrospectively.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. No individual patient data or images are presented.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"32"}}