{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:29:22Z","timestamp":1782548962260,"version":"3.54.5"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2020-C-023"],"award-info":[{"award-number":["CSH-2020-C-023"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2627-M-040-002"],"award-info":[{"award-number":["MOST 107-2627-M-040-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2621-M-040-001"],"award-info":[{"award-number":["108-2621-M-040-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2121-M-040-002"],"award-info":[{"award-number":["109-2121-M-040-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2121-M-040-002"],"award-info":[{"award-number":["110-2121-M-040-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Health Popul Nutr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Uterine fibroids (UFs) are uterine smooth muscle neoplasms that affect women, especially during the reproductive stage. Both genetic and lifestyle factors affect the onset of the disease. We examined the association between the estrogen receptor 1 (ESR1) rs2234693 variant (whose genotypes are TT, TC, and CC) and UFs in Taiwanese premenopausal and postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We linked individual-level data of 3588 participants from the Taiwan Biobank to the National Health Insurance Research Database at the Health and Welfare Data Science Center. The association of the ESR1 rs2234693 variant and other variables with UFs was determined by multiple logistic regression, and the results were presented as odds ratios and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3588 participants comprised 622 cases and 2966 controls. In all\u00a0the participants, the ESR1 rs2234693 TC and CC genotypes\u00a0compared to the reference genotype (TT) were associated with a lower risk of UFs. However, the results were significant only for the CC genotype (OR; 95% CI\u2009=\u20090.70; 0.52\u20130.93). Noteworthy, the association of TC and CC with UFs was dose-dependent (<jats:italic>p-trend<\/jats:italic>\u2009=\u20090.012). Based on menopausal status, both TC and CC were significantly and dose-dependently associated with a lower risk of UFs in premenopausal women (OR; 95% CI\u2009=\u20090.76; 0.59\u20130.98 for TC and 0.64; 0.43\u20130.95 for CC:<jats:italic>p-trend<\/jats:italic>\u2009=\u20090.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TC and CC genotypes of the ESR1 rs2234693 variant may reduce susceptibility to UFs, especially in premenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s41043-023-00357-7","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T08:03:35Z","timestamp":1678262615000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between ESR1 rs2234693 single nucleotide polymorphism and uterine fibroids in Taiwanese premenopausal and postmenopausal women"],"prefix":"10.1186","volume":"42","author":[{"given":"Yeu-Sheng","family":"Tyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disline Manli","family":"Tantoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hsiang","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald Ndi","family":"Nfor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Po","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"357_CR1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1289\/ehp.5787","volume":"111","author":"GP Flake","year":"2003","unstructured":"Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111:1037\u201354.","journal-title":"Environ Health Perspect"},{"key":"357_CR2","doi-asserted-by":"publisher","first-page":"e0188355","DOI":"10.1371\/journal.pone.0188355","volume":"12","author":"F Chiaffarino","year":"2017","unstructured":"Chiaffarino F, Cipriani S, Ricci E, La Vecchia C, Chiantera V, Bulfoni A, Parazzini F. Alcohol consumption and risk of uterine myoma: a systematic review and meta analysis. PLoS ONE. 2017;12:e0188355.","journal-title":"PLoS ONE"},{"key":"357_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2174\/1566524019666191014170912","volume":"20","author":"H Takala","year":"2020","unstructured":"Takala H, Yang Q, El Razek AMA, Ali M, Al-Hendy A. Alcohol consumption and risk of uterine fibroids. Curr Mol Med. 2020;20:247\u201358.","journal-title":"Curr Mol Med"},{"key":"357_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1933719115584449","volume":"23","author":"Q Yang","year":"2016","unstructured":"Yang Q, Mas A, Diamond MP, Al-Hendy A. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod Sci. 2016;23:163\u201375.","journal-title":"Reprod Sci"},{"key":"357_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1067\/mob.2003.99","volume":"188","author":"DD Baird","year":"2003","unstructured":"Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188:100\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"357_CR6","first-page":"413","volume":"5","author":"M Ezzati","year":"2009","unstructured":"Ezzati M, Norian JM, Segars JH. Management of uterine fibroids in the patient pursuing assisted reproductive technologies. Women\u2019s Health. 2009;5:413\u201321.","journal-title":"Women\u2019s Health"},{"key":"357_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/humupd\/dmt058","volume":"20","author":"JH Segars","year":"2014","unstructured":"Segars JH, Parrott EC, Nagel JD, Guo XC, Gao X, Birnbaum LS, Pinn VW, Dixon D. Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations. Hum Reprod Update. 2014;20:309\u201333.","journal-title":"Hum Reprod Update"},{"key":"357_CR8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1289\/ehp.00108s5821","volume":"108","author":"SM Schwartz","year":"2000","unstructured":"Schwartz SM, Marshall LM, Baird DD. Epidemiologic contributions to understanding the etiology of uterine leiomyomata. Environ Health Perspect. 2000;108:821\u20137.","journal-title":"Environ Health Perspect"},{"key":"357_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ogc.2012.09.005","volume":"39","author":"XC Guo","year":"2012","unstructured":"Guo XC, Segars JH. The impact and management of fibroids for fertility: an evidence-based approach. Obstet Gynecol Clin. 2012;39:521\u201333.","journal-title":"Obstet Gynecol Clin"},{"key":"357_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ejogrb.2018.07.032","volume":"229","author":"F Herv\u00e9","year":"2018","unstructured":"Herv\u00e9 F, Katty A, Isabelle Q, C\u00e9line S. Impact of uterine fibroids on quality of life: a national cross-sectional survey. Eur J Obstet Gynecol Reprod Biol. 2018;229:32\u20137.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"357_CR11","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1177\/1933719111432867","volume":"19","author":"M Sabry","year":"2012","unstructured":"Sabry M, Al-Hendy A. Medical treatment of uterine leiomyoma. Reprod Sci. 2012;19:339\u201353.","journal-title":"Reprod Sci"},{"key":"357_CR12","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1093\/humrep\/17.6.1424","volume":"17","author":"J Donnez","year":"2002","unstructured":"Donnez J, Jadoul P. What are the implications of myomas on fertility? A need for a debate? Hum Reprod. 2002;17:1424\u201330.","journal-title":"Hum Reprod"},{"key":"357_CR13","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/humrep\/dep396","volume":"25","author":"SK Sunkara","year":"2010","unstructured":"Sunkara SK, Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 2010;25:418\u201329.","journal-title":"Hum Reprod"},{"key":"357_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/943635","author":"M Sabry","year":"2012","unstructured":"Sabry M, Al-Hendy A. Innovative oral treatments of uterine leiomyoma. Obstet Gynecol Int. 2012. https:\/\/doi.org\/10.1155\/2012\/943635.","journal-title":"Obstet Gynecol Int"},{"key":"357_CR15","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1126\/science.1112063","volume":"308","author":"CL Walker","year":"2005","unstructured":"Walker CL, Stewart EA. Uterine fibroids: the elephant in the room. Science. 2005;308:1589\u201392.","journal-title":"Science"},{"key":"357_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2017.09.004","volume":"46","author":"D Pavone","year":"2018","unstructured":"Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2018;46:3\u201311.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"357_CR17","doi-asserted-by":"publisher","first-page":"e5325","DOI":"10.1097\/MD.0000000000005325","volume":"95","author":"YJ Tak","year":"2016","unstructured":"Tak YJ, Lee SY, Park SK, Kim YJ, Lee JG, Jeong DW, Kim SC, Kim IJ, Yi YH. Association between uterine leiomyoma and metabolic syndrome in parous premenopausal women: a case\u2013control study. Medicine. 2016;95:e5325.","journal-title":"Medicine"},{"key":"357_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/152460900318489","volume":"9","author":"F Sato","year":"2000","unstructured":"Sato F, Miyake H, Nishi M, Mori M, Kudo R. Early normal menstrual cycle pattern and the development of uterine leiomyomas. J Womens Health Gend Based Med. 2000;9:299\u2013302.","journal-title":"J Womens Health Gend Based Med"},{"key":"357_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/GRF.0000000000000164","volume":"59","author":"LA Wise","year":"2016","unstructured":"Wise LA, Laughlin-Tommaso SK. Epidemiology of uterine fibroids\u2013from menarche to menopause. Clin Obstet Gynecol. 2016;59:2.","journal-title":"Clin Obstet Gynecol"},{"key":"357_CR20","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/humrep\/deh309","volume":"19","author":"LA Wise","year":"2004","unstructured":"Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black women\u2019s health study. Hum Reprod. 2004;19:1746\u201354.","journal-title":"Hum Reprod"},{"key":"357_CR21","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/1471-0528.14640","volume":"124","author":"EA Stewart","year":"2017","unstructured":"Stewart EA, Cookson C, Gandolfo RA, Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG: Int J Obstet Gynaecol. 2017;124:1501\u201312.","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"357_CR22","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1007\/s13277-014-1606-9","volume":"35","author":"L Li","year":"2014","unstructured":"Li L, Zhang X, Xia Q, Ma H, Chen L, Hou W. Association between estrogen receptor alpha PvuII polymorphism and prostate cancer risk. Tumor Biol. 2014;35:4629\u201335.","journal-title":"Tumor Biol"},{"key":"357_CR23","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/j.1471-0528.1996.tb09911.x","volume":"103","author":"P Lumbiganon","year":"1996","unstructured":"Lumbiganon P, Rugpao S, Phandhu-fung S, Laopaiboon M, Vudhikamraksa N, Werawatakul Y. Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case-control study. BJOG: Int J Obstet Gynaecol. 1996;103:909\u201314.","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"357_CR24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/GME.0000000000001438","volume":"27","author":"M Ulin","year":"2020","unstructured":"Ulin M, Ali M, Chaudhry ZT, Al-Hendy A, Yang Q. Uterine fibroids in menopause and perimenopause. Menopause (New York, NY). 2020;27:238.","journal-title":"Menopause (New York, NY)"},{"key":"357_CR25","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1177\/1933719116678686","volume":"24","author":"MA Borahay","year":"2017","unstructured":"Borahay MA, Asoglu MR, Mas A, Adam S, Kilic GS, Al-Hendy A. Estrogen receptors and signaling in fibroids: role in pathobiology and therapeutic implications. Reprod Sci. 2017;24:1235\u201344.","journal-title":"Reprod Sci"},{"key":"357_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/aje\/kwh016","volume":"159","author":"LA Wise","year":"2004","unstructured":"Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study. Am J Epidemiol. 2004;159:113\u201323.","journal-title":"Am J Epidemiol"},{"key":"357_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/humupd\/dmh019","volume":"10","author":"T Maruo","year":"2004","unstructured":"Maruo T, Ohara N, Wang J, Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update. 2004;10:207\u201320.","journal-title":"Hum Reprod Update"},{"key":"357_CR28","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1289\/ehp.00108s5829","volume":"108","author":"DS Hunter","year":"2000","unstructured":"Hunter DS, Hodges LC, Eagon PK, Vonier PM, Fuchs-Young R, Bergerson JS, Walker CL. Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro\/in vivo animal model for uterine fibroids. Environ Health Perspect. 2000;108:829\u201334.","journal-title":"Environ Health Perspect"},{"key":"357_CR29","first-page":"331","volume":"45","author":"A Jakimiuk","year":"2007","unstructured":"Jakimiuk A, Nowicka M, Bogusiewicz M, Adamiak A, Skorupski P, Miotla P, Rechberger T, Haczynski J. Prevalence of estrogen receptor alpha PvuII and XbaI polymorphism in population of Polish postmenopausal women. Folia Histochem Cytobiol. 2007;45:331\u20138.","journal-title":"Folia Histochem Cytobiol"},{"key":"357_CR30","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1124\/mi.3.5.281","volume":"3","author":"J Matthews","year":"2003","unstructured":"Matthews J, Gustafsson J-\u00c5. Estrogen signaling: a subtle balance between ER\u03b1 and ER\u03b2. Mol Interv. 2003;3:281.","journal-title":"Mol Interv"},{"key":"357_CR31","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1161\/01.CIR.89.4.1501","volume":"89","author":"DW Losordo","year":"1994","unstructured":"Losordo DW, Kearney M, Kim EA, Jekanowski J, Isner JM. Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation. 1994;89:1501\u201310.","journal-title":"Circulation"},{"key":"357_CR32","doi-asserted-by":"publisher","first-page":"608","DOI":"10.5603\/EP.a2016.0058","volume":"67","author":"J Pinkas","year":"2016","unstructured":"Pinkas J, Gujski M, Wierzbi\u0144ska-St\u0119pniak A, Owoc A, Bojar I. The polymorphism of estrogen receptor \u03b1 is important for metabolic consequences associated with menopause. Endokrynol Pol. 2016;67:608\u201314.","journal-title":"Endokrynol Pol"},{"key":"357_CR33","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.fertnstert.2006.01.052","volume":"86","author":"A Al-Hendy","year":"2006","unstructured":"Al-Hendy A, Salama SA. Ethnic distribution of estrogen receptor-\u03b1 polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertil Steril. 2006;86:686\u201393.","journal-title":"Fertil Steril"},{"key":"357_CR34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1155\/2009\/580260","volume":"26","author":"S Govindan","year":"2009","unstructured":"Govindan S, Shaik NA, Vedicherla B, Kodati V, Rao KP, Hasan Q. Estrogen receptor-\u03b1 gene (T\/C) Pvu II polymorphism in endometriosis and uterine fibroids. Dis Mark. 2009;26:149\u201354.","journal-title":"Dis Mark"},{"key":"357_CR35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/molehr\/gal099","volume":"13","author":"Y-Y Hsieh","year":"2007","unstructured":"Hsieh Y-Y, Wang Y-K, Chang C-C, Lin C-S. Estrogen receptor \u03b1-351 Xba I* G and-397 Pvu II* C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. Mol Hum Reprod. 2007;13:117\u201322.","journal-title":"Mol Hum Reprod"},{"key":"357_CR36","doi-asserted-by":"crossref","unstructured":"Tang B, Preview of single nucleotide polymorphism (Snp) and potential correlation between human genomes and evolutionary history as well as religious behaviors. 2019.","DOI":"10.15226\/2475-4714\/4\/1\/00142"},{"key":"357_CR37","doi-asserted-by":"publisher","first-page":"100242","DOI":"10.1016\/j.crmeth.2022.100242","volume":"2","author":"LB Hyman","year":"2022","unstructured":"Hyman LB, Christopher CR, Romero PA. Competitive SNP-LAMP probes for rapid and robust single-nucleotide polymorphism detection. Cell Rep Methods. 2022;2:100242.","journal-title":"Cell Rep Methods"},{"key":"357_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-49935-y","volume":"9","author":"M Ueki","year":"2019","unstructured":"Ueki M, Kimura-Kataoka K, Fujihara J, Iida R, Kawai Y, Kusaka A, Sasaki T, Takeshita H, Yasuda T. Evaluation of the functional effects of genetic variants-missense and nonsense SNPs, indels and copy number variations-in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity. Sci Rep. 2019;9:1\u201311.","journal-title":"Sci Rep"},{"key":"357_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43042-022-00266-0","volume":"23","author":"W Chauhan","year":"2022","unstructured":"Chauhan W, Fatma R, Wahab A, Afzal M. Cataloging the potential SNPs (single nucleotide polymorphisms) associated with quantitative traits, viz. BMI (body mass index), IQ (intelligence quotient) and BP (blood pressure): an updated review. Egypt J Med Human Genet. 2022;23:1\u201324.","journal-title":"Egypt J Med Human Genet"},{"key":"357_CR40","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.7150\/jca.25638","volume":"9","author":"X Liu","year":"2018","unstructured":"Liu X, Huang J, Lin H, Xiong L, Ma Y, Lao H. ESR1 PvuII (rs2234693 T> C) polymorphism and cancer susceptibility: evidence from 80 studies. J Cancer. 2018;9:2963.","journal-title":"J Cancer"},{"key":"357_CR41","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10815-014-0393-y","volume":"32","author":"M He","year":"2015","unstructured":"He M, Shu J, Huang X, Tang H. Association between estrogen receptora gene (ESR1) PvuII (T\/C) and XbaI (A\/G) polymorphisms and premature ovarian failure risk: evidence from a meta-analysis. J Assist Reprod Genet. 2015;32:297\u2013304.","journal-title":"J Assist Reprod Genet"},{"key":"357_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.5114\/pm.2018.81735","volume":"17","author":"M Ciebiera","year":"2018","unstructured":"Ciebiera M, Wrzosek M, Wojty\u0142a C, \u0141ozi\u0144ski T, Nowicka G, Jakiel G, G\u0142owala M, W\u0142odarczyk M. Oestrogen receptor alpha PvuII polymorphism and uterine fibroid incidence in Caucasian women. Przeglad Menopauzalny = Menopaus Rev. 2018;17:149.","journal-title":"Przeglad Menopauzalny = Menopaus Rev"},{"key":"357_CR43","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.fertnstert.2005.07.1308","volume":"85","author":"D Denschlag","year":"2006","unstructured":"Denschlag D, Bentz E-K, Hefler L, Pietrowski D, Zeillinger R, Tempfer C, Tong D. Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas. Fertil Steril. 2006;85:462\u20137.","journal-title":"Fertil Steril"},{"key":"357_CR44","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S0015-0282(00)01760-X","volume":"75","author":"F Massart","year":"2001","unstructured":"Massart F, Becherini L, Gennari L, Facchini V, Genazzani AR, Brandi ML. Genotype distribution of estrogen receptor-\u03b1 gene polymorphisms in Italian women with surgical uterine leiomyomas. Fertil Steril. 2001;75:567\u201370.","journal-title":"Fertil Steril"},{"key":"357_CR45","first-page":"BR25","volume":"9","author":"F Massart","year":"2003","unstructured":"Massart F, Becherini L, Marini F, Noci I, Piciocchi L, Del Monte F, Masi L, Falchetti A, Tanini A, Scarselli G. Analysis of estrogen receptor (ER\u03b1 and ER\u00df) and progesterone receptor (PR) polymorphisms in uterine leiomyomas. Med Sci Monit. 2003;9:BR25\u201330.","journal-title":"Med Sci Monit"},{"key":"357_CR46","first-page":"225","volume":"16","author":"FT Mortezaee","year":"2014","unstructured":"Mortezaee FT, Tabatabaiefar MA, Chaleshtori MH, Miraj S. Lack of association between ESR1 and CYP1A1 gene polymorphisms and susceptibility to uterine leiomyoma in female patients of Iranian descent. Cell J (Yakhteh). 2014;16:225.","journal-title":"Cell J (Yakhteh)"},{"key":"357_CR47","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2217\/14622416.9.2.235","volume":"9","author":"C-T Fan","year":"2008","unstructured":"Fan C-T, Lin J-C, Lee C-H. Taiwan Biobank: a project aiming to aid Taiwan\u2019s transition into a biomedical island. Pharmacogenomics. 2008;9:235\u201346.","journal-title":"Pharmacogenomics"},{"key":"357_CR48","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2147\/CLEP.S196293","volume":"11","author":"C-Y Hsieh","year":"2019","unstructured":"Hsieh C-Y, Su C-C, Shao S-C, Sung S-F, Lin S-J. Yang Y-HK, Lai EC-C: Taiwan\u2019s national health insurance research database: past and future. Clin Epidemiol. 2019;11:349.","journal-title":"Clin Epidemiol"},{"key":"357_CR49","doi-asserted-by":"crossref","unstructured":"McElroy J, Kruse RL, Taylor JF, Candidate genetic polymorphisms and haplotypes associated with endometrial cancer risk. In ISEE conference abstracts 2016.","DOI":"10.1289\/isee.2016.3530"},{"key":"357_CR50","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ijheh.2019.02.004","volume":"222","author":"C-Y Lin","year":"2019","unstructured":"Lin C-Y, Wang C-M, Chen M-L, Hwang B-F. The effects of exposure to air pollution on the development of uterine fibroids. Int J Hyg Environ Health. 2019;222:549\u201355.","journal-title":"Int J Hyg Environ Health"},{"key":"357_CR51","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/cancers12020504","volume":"12","author":"C-L Su","year":"2020","unstructured":"Su C-L, Tantoh DM, Chou Y-H, Wang L, Ho C-C, Chen P-H, Lee K-J, Nfor ON, Hsu S-Y, Liang W-M. Blood-based SOX2-promoter methylation in relation to exercise and PM2. 5 exposure among Taiwanese adults. Cancers. 2020;12:504.","journal-title":"Cancers"},{"key":"357_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13148-019-0662-9","volume":"11","author":"DM Tantoh","year":"2019","unstructured":"Tantoh DM, Lee K-J, Nfor ON, Liaw Y-C, Lin C, Chu H-W, Chen P-H, Hsu S-Y, Liu W-H, Ho C-C. Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM 2.5 concentrations. Clin Epigenet. 2019;11:69.","journal-title":"Clin Epigenet"},{"key":"357_CR53","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, De Bakker PI, Daly MJ. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Human Genet. 2007;81:559\u201375.","journal-title":"Am J Human Genet"},{"key":"357_CR54","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000218711","volume":"13","author":"A Adeyemo","year":"2010","unstructured":"Adeyemo A, Rotimi C. Genetic variants associated with complex human diseases show wide variation across multiple populations. Public Health Genomics. 2010;13:72\u20139.","journal-title":"Public Health Genomics"},{"key":"357_CR55","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1017\/S0007114508083566","volume":"101","author":"C Nagata","year":"2009","unstructured":"Nagata C, Nakamura K, Oba S, Hayashi M, Takeda N, Yasuda K. Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women. Br J Nutr. 2009;101:1427\u201331.","journal-title":"Br J Nutr"},{"key":"357_CR56","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1111\/j.1471-0528.2009.02185.x","volume":"116","author":"KA Ashton","year":"2009","unstructured":"Ashton KA, Proietto A, Otton G, Symonds I, McEvoy M, Attia J, Gilbert M, Hamann U, Scott RJ. Estrogen receptor polymorphisms and the risk of endometrial cancer. BJOG: Int J Obstet Gynaecol. 2009;116:1053\u201361.","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"357_CR57","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1001\/jama.291.24.2969","volume":"291","author":"SC Schuit","year":"2004","unstructured":"Schuit SC, Oei H-HS, Witteman JC, van Kessel CHG, van Meurs JB, Nijhuis RL, van Leeuwen JP, de Jong FH, Zillikens MC, Hofman A. Estrogen receptor \u03b1 gene polymorphisms and risk of myocardial infarction. JAMA. 2004;291:2969\u201377.","journal-title":"JAMA"},{"key":"357_CR58","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1161\/01.CIR.0000016173.98826.88","volume":"105","author":"DM Herrington","year":"2002","unstructured":"Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation. 2002;105:1879\u201382.","journal-title":"Circulation"},{"key":"357_CR59","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1530\/eje.1.01973","volume":"153","author":"SC Schuit","year":"2005","unstructured":"Schuit SC, de Jong FH, Stolk L, Koek WNH, van Meurs JB, Schoofs MW, Zillikens MC, Hofman A, van Leeuwen JP, Pols HA. Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women. Eur J Endocrinol. 2005;153:327\u201334.","journal-title":"Eur J Endocrinol"},{"key":"357_CR60","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.maturitas.2006.01.013","volume":"55","author":"F Parazzini","year":"2006","unstructured":"Parazzini F. Risk factors for clinically diagnosed uterine fibroids in women around menopause. Maturitas. 2006;55:174\u20139.","journal-title":"Maturitas"},{"key":"357_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40738-016-0022-9","volume":"2","author":"BD Sarkodie","year":"2016","unstructured":"Sarkodie BD, Botwe BO, Adjei DN, Ofori E. Factors associated with uterine fibroid in Ghanaian women undergoing pelvic scans with suspected uterine fibroid. Fertil Res Pract. 2016;2:1\u20137.","journal-title":"Fertil Res Pract"},{"key":"357_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/aje\/153.1.1","volume":"153","author":"E Faerstein","year":"2001","unstructured":"Faerstein E, Szklo M, Rosenshein N. Risk factors for uterine leiomyoma: a practice-based case-control study. I. African-American heritage, reproductive history, body size, and smoking. Am J Epidemiol. 2001;153:1\u201310.","journal-title":"Am J Epidemiol"},{"key":"357_CR63","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/jog.12834","volume":"42","author":"Y Shen","year":"2016","unstructured":"Shen Y, Wu Y, Lu Q, Ren M. Vegetarian diet and reduced uterine fibroids risk: a case\u2013control study in Nanjing, China. J Obstet Gynaecol Res. 2016;42:87\u201394.","journal-title":"J Obstet Gynaecol Res"},{"key":"357_CR64","first-page":"109","volume":"22","author":"Y He","year":"2013","unstructured":"He Y, Zeng Q, Dong S, Qin L, Li G, Wang P. Associations between uterine fibroids and lifestyles including diet, physical activity and stress: a case\u2013control study in China. Asia Pac J Clin Nutr. 2013;22:109\u201317.","journal-title":"Asia Pac J Clin Nutr"},{"key":"357_CR65","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/aje\/153.1.11","volume":"153","author":"E Faerstein","year":"2001","unstructured":"Faerstein E, Szklo M, Rosenshein NB. Risk factors for uterine leiomyoma: a practice-based case-control study. II. Atherogenic risk factors and potential sources of uterine irritation. Am J Epidem. 2001;153:11\u20139.","journal-title":"Am J Epidem"},{"key":"357_CR66","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1524-6175.2005.04384.x","volume":"7","author":"MA Silver","year":"2005","unstructured":"Silver MA, Raghuvir R, Fedirko B, Elser D. Systemic hypertension among women with uterine leiomyomata: potential final common pathways of target end-organ remodeling. J Clin Hypertens. 2005;7:664\u20138.","journal-title":"J Clin Hypertens"},{"key":"357_CR67","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000114250","volume":"66","author":"T Takeda","year":"2008","unstructured":"Takeda T, Sakata M, Isobe A, Miyake A, Nishimoto F, Ota Y, Kamiura S, Kimura T. Relationship between metabolic syndrome and uterine leiomyomas: a case\u2013control study. Gynecol Obstet Invest. 2008;66:14\u20137.","journal-title":"Gynecol Obstet Invest"},{"key":"357_CR68","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2188\/jea.12.249","volume":"12","author":"F Sato","year":"2002","unstructured":"Sato F, Mori M, Nishi M, Kudo R, Miyake H. Familial aggregation of uterine myomas in Japanese women. J Epidemiol. 2002;12:249\u201353.","journal-title":"J Epidemiol"},{"key":"357_CR69","first-page":"3249","volume":"17","author":"Y Shen","year":"2013","unstructured":"Shen Y, Xu Q, Xu J, Ren M, Cai Y. Environmental exposure and risk of uterine leiomyoma: an epidemiologic survey. Eur Rev Med Pharmacol Sci. 2013;17:3249\u201356.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"357_CR70","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/j.fertnstert.2016.09.007","volume":"106","author":"M Ciebiera","year":"2016","unstructured":"Ciebiera M, W\u0142odarczyk M, S\u0142abuszewska-J\u00f3\u017awiak A, Nowicka G, Jakiel G. Influence of vitamin D and transforming growth factor \u03b23 serum concentrations, obesity, and family history on the risk for uterine fibroids. Fertil Steril. 2016;106:1787\u201392.","journal-title":"Fertil Steril"},{"key":"357_CR71","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1089\/jwh.2016.5913","volume":"26","author":"L Song","year":"2017","unstructured":"Song L, Shen L, Mandiwa C, Yang S, Liang Y, Yuan J, Wang Y. Induced and spontaneous abortion and risk of uterine fibroids. J Womens Health. 2017;26:76\u201382.","journal-title":"J Womens Health"},{"key":"357_CR72","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007918","author":"W-C Hsu","year":"2019","unstructured":"Hsu W-C, Tsai Y-T, Hou Y-C, Lai J-N. Prescription of Chinese herbal products is associated with a decreased risk of uterine fibroids: a population-based cohort study. Medicine. 2019. https:\/\/doi.org\/10.1097\/MD.0000000000007918.","journal-title":"Medicine"},{"key":"357_CR73","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/617918","author":"S-Y Su","year":"2012","unstructured":"Su S-Y, Muo C-H, Morisky DE. Use of chinese medicine and subsequent surgery in women with uterine fibroid: a retrospective cohort study. Evid-Based Complement Altern Med. 2012. https:\/\/doi.org\/10.1155\/2012\/617918.","journal-title":"Evid-Based Complement Altern Med"},{"key":"357_CR74","doi-asserted-by":"crossref","unstructured":"Li Z-L, Huang T-Y, Ho Y, Shih Y-J, Chen Y-R, Tang H-Y, Lin H-Y, Whang-Peng J, Wang K, Herbal medicine in uterine fibroid. In Fibroids. IntechOpen; 2020","DOI":"10.5772\/intechopen.94101"}],"container-title":["Journal of Health, Population and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41043-023-00357-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41043-023-00357-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41043-023-00357-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T23:42:26Z","timestamp":1729035746000},"score":1,"resource":{"primary":{"URL":"https:\/\/jhpn.biomedcentral.com\/articles\/10.1186\/s41043-023-00357-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":74,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["357"],"URL":"https:\/\/doi.org\/10.1186\/s41043-023-00357-7","relation":{},"ISSN":["2072-1315"],"issn-type":[{"value":"2072-1315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"13 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for this work was granted by the Institutional Review Board of the Chung Shan Medical University Hospital (CS2-20006). All participants signed an informed consent letter before their enrolment into the Taiwan Biobank project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}