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It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistics and Cochrane <jats:italic>Q<\/jats:italic> test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pooled analysis using the random-effects model of the 8 case\u2013control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD: \u2212\u00a03.41 ng\/ml, 95% CI \u2212\u00a05.02, \u2212\u00a01.80, <jats:italic>p<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.001) and adults (WMD: \u2212\u00a02.60 ng\/ml, 95% CI \u2212\u00a04.32, \u2212\u00a00.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20\u201330 ng\/ml in CF patients was 36% among pediatrics\/adolescents and 63% among adults. In addition, 27% of pediatric\/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng\/ml.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41043-024-00499-2","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:33:22Z","timestamp":1705494802000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"43","author":[{"given":"Nazanin","family":"Farahbakhsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaye","family":"Fatahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Shirvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monireh Sadat","family":"Motaharifard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Mohkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ahmad","family":"Tabatabaii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghamartaj","family":"khanbabaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Yaghoobpoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Zahra","family":"Davoodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir hossein","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"10059","key":"499_CR1","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","volume":"388","author":"JS Elborn","year":"2016","unstructured":"Elborn JS. 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