{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:06:50Z","timestamp":1772028410737,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hereditas"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>The present study was conducted with the objective ascertaining the clinical implication of microRNA-133a-3p (miR-133a-3p) for urinary incontinence (UI) and rehabilitation effects in prostate cancer after radical prostatectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The measurements of miR-133a-3p in urethral tissue samples from prostate cancer patients after radical prostatectomy were carried out via quantitative real-time polymerase chain reaction (qRT-PCR) detection. Receiver operation characteristic (ROC) curve and logistic regression analysis were employed for evaluating the predictive significance of miR-133a-3p for the early UI of prostate cancer patients with radical prostatectomy. Bioinformatics tools were employed for mining the miR-133a-3p possible genes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>An obvious reduction of miR-133a-3p was detected in patients with UI compared with those with urinary continence (UC) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), demonstrating a high diagnostic capacity for patients with UI. Moreover, miR-133a-3p could be an independent predictive index for the early UI in patients with prostate cancer after radical prostatectomy (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Additionally, urine miR-133a-3p was notably increased in the UI patients after rehabilitation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MiR-133a-3p largely concentered on the muscle-related diseases pathways using bioinformatics tools.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>MiR-133a-3p was a promising indicator for predicting early UI in patients with prostate cancer after radical prostatectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical trial number<\/jats:title>\n            <jats:p>Not applicable.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s41065-025-00443-2","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T12:11:41Z","timestamp":1746965501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED ARTICLE: Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects"],"prefix":"10.1186","volume":"162","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"issue":"4","key":"443_CR1","first-page":"CD014799","volume":"4","author":"EE Johnson","year":"2023","unstructured":"Johnson EE, Mamoulakis C, Stoniute A, Omar MI, Sinha S. Conservative interventions for managing urinary incontinence after prostate surgery. Cochrane Database Syst Rev. 2023;4(4):CD014799.","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"443_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.maturitas.2009.06.005","volume":"63","author":"BA Parsons","year":"2009","unstructured":"Parsons BA, Evans S, Wright MP. Prostate cancer and urinary incontinence. Maturitas. 2009;63(4):323\u20138.","journal-title":"Maturitas"},{"issue":"3","key":"443_CR3","first-page":"174","volume":"27","author":"LL Powel","year":"2000","unstructured":"Powel LL. Quality of life in men with urinary incontinence after prostate cancer surgery. J Wound Ostomy Cont Nurs. 2000;27(3):174\u20138.","journal-title":"J Wound Ostomy Cont Nurs"},{"issue":"3","key":"443_CR4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.ucl.2022.04.005","volume":"49","author":"GE Koch","year":"2022","unstructured":"Koch GE, Kaufman MR. Male stress urinary incontinence. Urol Clin North Am. 2022;49(3):403\u201318.","journal-title":"Urol Clin North Am"},{"issue":"19","key":"443_CR5","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.1080\/09638288.2021.1937717","volume":"44","author":"FT Baumann","year":"2022","unstructured":"Baumann FT, Reimer N, Gockeln T, Reike A, Hallek M, Ricci C, et al. Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy - a systematic review and meta-analysis. Disabil Rehabil. 2022;44(19):5374\u201385.","journal-title":"Disabil Rehabil"},{"key":"443_CR6","doi-asserted-by":"crossref","unstructured":"Ho PTB, Clark IM, Le LTT. MicroRNA-Based diagnosis and therapy. Int J Mol Sci. 2022;23(13).","DOI":"10.3390\/ijms23137167"},{"key":"443_CR7","doi-asserted-by":"crossref","unstructured":"Liu Q, Novak MK, Pepin RM, Eich T, Hu W. MicroRNA-mediated regulation of microRNA machinery controls cell fate decisions. Elife. 2021;10:e72289.","DOI":"10.7554\/eLife.72289"},{"issue":"1","key":"443_CR8","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/s41598-024-51451-7","volume":"14","author":"B Xue","year":"2024","unstructured":"Xue B, Kadeerhan G, Sun LB, Chen YQ, Hu XF, Zhang ZK, et al. Circulating Exosomal miR-16-5p and let-7e-5p are associated with bladder fibrosis of diabetic cystopathy. Sci Rep. 2024;14(1):837.","journal-title":"Sci Rep"},{"issue":"1","key":"443_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12894-020-00765-5","volume":"20","author":"B Liu","year":"2020","unstructured":"Liu B, Ding Y, Li P, Wang T, He S, Jia Z, et al. MicroRNA-219c-5p regulates bladder fibrosis by targeting FN1. BMC Urol. 2020;20(1):193.","journal-title":"BMC Urol"},{"issue":"1","key":"443_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13287-016-0428-7","volume":"7","author":"M Jin","year":"2016","unstructured":"Jin M, Wu Y, Wang J, Ye W, Wang L, Yin P, et al. MicroRNA-29 facilitates transplantation of bone marrow-derived mesenchymal stem cells to alleviate pelvic floor dysfunction by repressing Elastin. Stem Cell Res Ther. 2016;7(1):167.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"443_CR11","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13046-018-0813-4","volume":"37","author":"Y Tang","year":"2018","unstructured":"Tang Y, Pan J, Huang S, Peng X, Zou X, Luo Y, et al. Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K\/AKT signaling. J Exp Clin Cancer Res. 2018;37(1):160.","journal-title":"J Exp Clin Cancer Res"},{"key":"443_CR12","doi-asserted-by":"crossref","unstructured":"Yu YN, Ren YY, Shao ZL, Chen BL, Cui BY, Chao CY et al. Perillaldehyde improves diabetic cardiomyopathy by upregulating miR-133a-3p to regulate GSK-3beta. Eur J Pharmacol. 2023;953:175836.","DOI":"10.1016\/j.ejphar.2023.175836"},{"issue":"3","key":"443_CR13","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1538\/expanim.20-0159","volume":"70","author":"AR Hirman","year":"2021","unstructured":"Hirman AR, Du L, Cheng S, Zheng H, Duo L, Zhai Q, et al. MiR-133a-3p inhibits Scar formation in scalded mice and suppresses the proliferation and migration of Scar derived-fibroblasts by targeting connective tissue growth factor. Exp Anim. 2021;70(3):322\u201332.","journal-title":"Exp Anim"},{"key":"443_CR14","first-page":"39","volume":"101123","author":"M Lodyga","year":"2020","unstructured":"Lodyga M, Hinz B. TGF-beta1 - A truly transforming growth factor in fibrosis and immunity. Semin Cell Dev Biol. 2020;101123:39.","journal-title":"Semin Cell Dev Biol"},{"issue":"47","key":"443_CR15","doi-asserted-by":"publisher","first-page":"9684","DOI":"10.1039\/D1TB02170B","volume":"9","author":"C Hu","year":"2021","unstructured":"Hu C, Liu W, Long L, Wang Z, Yuan Y, Zhang W, et al. Microenvironment-responsive multifunctional hydrogels with Spatiotemporal sequential release of tailored Recombinant human collagen type III for the rapid repair of infected chronic diabetic wounds. J Mater Chem B. 2021;9(47):9684\u201399.","journal-title":"J Mater Chem B"},{"issue":"2","key":"443_CR16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cellsig.2014.11.001","volume":"27","author":"LJ Duan","year":"2015","unstructured":"Duan LJ, Qi J, Kong XJ, Huang T, Qian XQ, Xu D, et al. MiR-133 modulates TGF-beta1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of MicroRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal. 2015;27(2):215\u201327.","journal-title":"Cell Signal"},{"issue":"4","key":"443_CR17","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s13105-024-01043-w","volume":"80","author":"D Qiu","year":"2024","unstructured":"Qiu D, Zhang Y, Ni P, Wang Z, Yang L, Li F. Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise. J Physiol Biochem. 2024;80(4):795\u2013809.","journal-title":"J Physiol Biochem"},{"key":"443_CR18","doi-asserted-by":"crossref","unstructured":"Bakinowska E, Olejnik-Wojciechowska J, Kielbowski K, Skoryk A, Pawlik A. Pathogenesis of sarcopenia in chronic kidney Disease-The role of inflammation, metabolic dysregulation, gut dysbiosis, and MicroRNA. Int J Mol Sci. 2024;25(15).","DOI":"10.3390\/ijms25158474"},{"issue":"6","key":"443_CR19","first-page":"219","volume":"6","author":"AH Gheinani","year":"2018","unstructured":"Gheinani AH, Kock I, Vasquez E, Baumgartner U, Bigger-Allen A, Sack BS, et al. Concordant MiRNA and mRNA expression profiles in humans and mice with bladder outlet obstruction. Am J Clin Exp Urol. 2018;6(6):219\u201333.","journal-title":"Am J Clin Exp Urol"},{"issue":"1","key":"443_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12951-021-00808-5","volume":"19","author":"W Zhu","year":"2021","unstructured":"Zhu W, Sun L, Zhao P, Liu Y, Zhang J, Zhang Y, et al. Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p. J Nanobiotechnol. 2021;19(1):61.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"443_CR21","doi-asserted-by":"publisher","first-page":"151653","DOI":"10.1016\/j.acthis.2020.151653","volume":"123","author":"YF Zhu","year":"2021","unstructured":"Zhu YF, Wang R, Chen W, Cao YD, Li LP, Chen X. miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKepsilon. Acta Histochem. 2021;123(1):151653.","journal-title":"Acta Histochem"},{"issue":"12","key":"443_CR22","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1177\/03635465221119507","volume":"50","author":"JE Schanda","year":"2022","unstructured":"Schanda JE, Heher P, Weigl M, Drechsler S, Schadl B, Prueller J, et al. Muscle-Specific Micro-Ribonucleic acids miR-1-3p, miR-133a-3p, and miR-133b reflect muscle regeneration after Single-Dose Zoledronic acid following rotator cuff repair in a rodent chronic defect model. Am J Sports Med. 2022;50(12):3355\u201367.","journal-title":"Am J Sports Med"},{"key":"443_CR23","doi-asserted-by":"crossref","unstructured":"Antar SA, Ashour NA, Marawan ME, Al-Karmalawy AA, Fibrosis. Types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation. Int J Mol Sci. 2023;24(4).","DOI":"10.3390\/ijms24044004"},{"issue":"2","key":"443_CR24","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1046\/j.1524-475x.2000.00128.x","volume":"8","author":"R Wang","year":"2000","unstructured":"Wang R, Ghahary A, Shen Q, Scott PG, Roy K, Tredget EE. Hypertrophic Scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound Repair Regen. 2000;8(2):128\u201337.","journal-title":"Wound Repair Regen"},{"key":"443_CR25","doi-asserted-by":"crossref","unstructured":"Fischer AG, Elliott EM, Brittian KR, Garrett L, Sadri G, Aebersold J et al. Matricellular protein CCN1 promotes collagen alignment and Scar integrity after myocardial infarction. Matrix Biol. 2024;133:14\u201332.","DOI":"10.1016\/j.matbio.2024.08.001"},{"issue":"9","key":"443_CR26","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/s41419-019-1873-x","volume":"10","author":"P Wei","year":"2019","unstructured":"Wei P, Xie Y, Abel PW, Huang Y, Ma Q, Li L, et al. Transforming growth factor (TGF)-beta1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death Dis. 2019;10(9):670.","journal-title":"Cell Death Dis"},{"issue":"1","key":"443_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12951-023-02020-z","volume":"21","author":"S Song","year":"2023","unstructured":"Song S, Zhang G, Chen X, Zheng J, Liu X, Wang Y, et al. HIF-1alpha increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1alpha\/VEGF\/AKT\/mTOR signaling pathway. J Nanobiotechnol. 2023;21(1):257.","journal-title":"J Nanobiotechnol"},{"issue":"10","key":"443_CR28","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1158\/1078-0432.CCR-22-3350","volume":"29","author":"K Chaudagar","year":"2023","unstructured":"Chaudagar K, Hieromnimon HM, Khurana R, Labadie B, Hirz T, Mei S, et al. Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN\/p53-deficient prostate Cancer. Clin Cancer Res. 2023;29(10):1952\u201368.","journal-title":"Clin Cancer Res"}],"updated-by":[{"DOI":"10.1186\/s41065-025-00595-1","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"record-id":"68815"},{"DOI":"10.1186\/s41065-025-00595-1","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000}}],"container-title":["Hereditas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41065-025-00443-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41065-025-00443-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41065-025-00443-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:18:50Z","timestamp":1760703530000},"score":1,"resource":{"primary":{"URL":"https:\/\/hereditasjournal.biomedcentral.com\/articles\/10.1186\/s41065-025-00443-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["443"],"URL":"https:\/\/doi.org\/10.1186\/s41065-025-00443-2","relation":{},"ISSN":["1601-5223"],"issn-type":[{"value":"1601-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]},"assertion":[{"value":"12 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s41065-025-00595-1","URL":"https:\/\/doi.org\/10.1186\/s41065-025-00595-1","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Tongji Hospital before the study began. The written informed consent has been obtained from the participants involved.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"75"}}